Risk Factors for Local Recurrence and Optimal Length of Esophagectomy in Esophageal Squamous Cell Carcinoma

Kang, Chang Hyun; Hwang, Yoohwa; Lee, Hyun Joo; Park, In Kyu; Kim, Young Tae

doi:10.1016/j.athoracsur.2016.03.117

Cited by 17 publications

(14 citation statements)

References 17 publications

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“…Endoscopic resection is associated with a lower morbidity rate, but recurrence rates are higher than those of surgery. Lymph node involvement is a risk factor for tumour recurrence. In an analysis of 715 patients with early oesophageal adenocarcinoma from the Surveillance, Epidemiology, and End Results (SEER) database, Gamboa and colleagues found that tumour grade, T classification and tumour size were independently associated with lymph node involvement.…”

Section: Discussionmentioning

confidence: 99%

Nomogram to predict lymph node metastasis in patients with early oesophageal squamous cell carcinoma

Zheng

Tang

Wang

et al. 2018

British Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Nomogram to predict lymph node metastasis in patients with early oesophageal squamous cell carcinoma

Zheng

Tang

Wang

et al. 2018

British Journal of Surgery

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“…[ 23 ] In one of these studies, which was conducted in 352 patients, Barbour et al[ 24 ] reported that a clear proximal border of approximately 5 cm was an independent prognostic factor in survival. On the other hand, in another study in 516 patients with ESCC, Kang et al[ 25 ] found the mean proximal resection margin to be 3.4±2.5 cm, and they found the possibility of recurrence to be significantly higher in patients with N (+) with a border length of >5 cm. However, in the current study, the survival rates of the patients with a proximal surgical margin length between 5 and 10 cm were statistically significantly higher than the others (p<0.001).…”

Section: Discussionmentioning

confidence: 98%

What are the independent prognostic factors in patients undergoing esophagectomy for esophageal cancer?

Alcan

Ergin

Keskin

et al. 2022

Turk Gogus Kalp Dama

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Background: This study aims to investigate the prognostic factors affecting survival in patients undergoing surgical treatment for esophageal cancer. Methods: A total of 50 patients (33 males, 17 females; mean age: 57.8±11.8 years; range, 28 to 80 years) who underwent esophagectomy for esophageal cancer in our clinic between January 2008 and March 2018 were retrospectively analyzed. Prognostic factors affecting survival were investigated. Data including age, sex, tumor size, histological and macroscopic type, tumor stage, T and N categories, the total number of resected lymph nodes and metastatic lymph node ratio, differentiation degree, vascular and perineural invasion, proximal surgical margin distance, adjuvant therapy, and the presence of postoperative complications were recorded. Results: The patients after radical surgery with a tumor size of <3 cm, macroscopic type non-ulcerative-infiltrative squamous cell carcinoma pathology, Stage 1 disease, pT1-2, pN0, well-differentiated groups, no perineural invasion, a metastatic lymph node ratio of <0.2, proximal surgery margin length of 5 to 10 cm, and no postoperative complications had higher five-year survival rates. However, when the effects of these factors on overall survival were examined independently, none of them had a statistically significant effect (p>0.05). The main factors affecting the prognosis were Stage ?2 disease, postoperative complications, and proximal surgical margin less than 5 cm. Conclusion: Our study results suggest that Stage 1 disease, a proximal surgical margin length of more than 5 cm, and the absence of complications are associated with longer survival times and these patients are greatly benefited from surgical treatment.

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“…Previous studies have shown that advanced stage indicators including T and N in pathological examination are risk factors for the recurrence of ESCC following curative resection [17][18][19][20][21]. Wang et al [18] reported that patients with pN had a much higher recurrence rate than patients without pN.…”

Section: Discussionmentioning

confidence: 99%

“…In such analysis of ESCC patients who underwent neoadjuvant CRT and esophagectomy, lymphovascular invasion was indicated as an independent risk factor for recurrence [14][15][16]. Advanced stage indicators including T and N in pathological diagnosis are also risk factors for recurrence of ESCC following curative resection with or without neoadjuvant therapy [17][18][19][20][21]. However, the risk factors for recurrence after esophagectomy with NAC alone for ESCC have not been clari ed so far.…”

Section: Introductionmentioning

confidence: 99%

Clinical Impact of Remnant Lymphatic Invasion on The Recurrence of Esophageal Squamous Cell Carcinoma After Esophagectomy with Neoadjuvant Chemotherapy: A Retrospective Study

Okuda

Ohuchida

Shindo

et al. 2022

Preprint

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Background: For stage II and III esophageal squamous cell carcinoma (ESCC), neoadjuvant chemotherapy (NAC) followed by esophagectomy is recommended in Japanese guidelines. However, recurrence of ESCC is common regardless of the NAC regimen and operation method, and the effect of NAC on recurrence is limited.Methods: We retrospectively analyzed the outcomes of 54 patients who underwent esophagectomy for ESCC after NAC from 2010 to 2017. We selected 53 patients with ESCC without NAC followed by esophagectomy from 2001 to 2017 for comparison.Results: Among patients who underwent NAC followed by surgery, lymphatic invasion (ly) (hazard ratio: 2.632; 95% CI: 1.04–6.68, p = 0.042) and microscopic residual tumor (R) (hazard ratio: 24.21, 95% CI: 1.92–305, p = 0.014) were independent factors significantly associated with 3-year recurrence-free survival in patients with esophagectomy after NAC in multivariate analysis. In patients without ly after NAC, the presence of lymph node metastasis in pathological diagnosis (pN) was not significantly related to recurrence (p = 0.2401). Recurrence was significantly related to ly (+) (p = 0.0024) in the group with pN after NAC. There were significantly fewer ly (+) patients in the NAC (+) group (p = 0.0332) than those in the NAC (-) group.Conclusion: The presence of ly was an independent risk factor for recurrence of ESCC after esophagectomy following NAC. pN was not a significant recurrence factor for cases with esophagectomy following NAC in multivariate analysis. Adjuvant treatment after surgery may be required in cases with remnant ly after NAC.

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Risk Factors for Local Recurrence and Optimal Length of Esophagectomy in Esophageal Squamous Cell Carcinoma

Cited by 17 publications

References 17 publications

Nomogram to predict lymph node metastasis in patients with early oesophageal squamous cell carcinoma

Nomogram to predict lymph node metastasis in patients with early oesophageal squamous cell carcinoma

What are the independent prognostic factors in patients undergoing esophagectomy for esophageal cancer?

Clinical Impact of Remnant Lymphatic Invasion on The Recurrence of Esophageal Squamous Cell Carcinoma After Esophagectomy with Neoadjuvant Chemotherapy: A Retrospective Study

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