Risk factors for low high-density lipoprotein among Asian Indians in the United States

Lucke‐Wold, Brandon; Misra, Ranjita; Patel, Thakor G.

doi:10.4239/wjd.v8.i6.297

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…The mean fluorescence intensity (MFI) of TCRβ on CD8 SP T-cells was reduced in infected thymi, consistent with activation-induced TCR downregulation (Fig. 5D) (26). We further found that these cells were positive for KLRG1, CD69, and CD44 while having decreased expression of CD62L, as compared to CD8 SP thymocytes from uninfected mice, consistent with effector T cells (Fig.…”

Section: Resultssupporting

confidence: 72%

CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection

Patel

Yokoyama

2017

The Journal of Immunology

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A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4+ cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with prior studies on a related virus, mouse thymic virus (MTV). Herein we show that in contrast to published studies on MTV, MRV appears to robustly infect neonatal C57BL/6 (B6) mice causing severe depletion of thymocytes and peripheral T-cells. Moreover, B6 mice recovered from infection. We investigated the mechanism of thymocyte and T-cell loss, determining that the major thymocyte subsets were infected with MRV, however CD4+ and CD4+CD8− showed increased apoptosis during infection. We found that CD8+ T-cells populated MRV-infected thymi. These CD8+ T cells expressed markers of activation, had restricted T-cell receptor repertoire and accumulated intracellular effector proteins, consistent with a cytotoxic lymphocyte phenotype, and suggesting their involvement in viral clearance. Indeed, absence of CD8+ T-cells prevented recovery from MRV infection and led to lethality in infected animals whereas B-cell deficient mice showed CD4+ T-cell loss but recovered from infection without lethality. Thus these results demonstrate that CD8+ T-cells are required for protective immunity against a naturally occurring murine pathogen that infects the thymus, and establish a novel infection model for MRV in B6 mice, providing the foundation for detailed future studies on MRV with the availability of innumerable mutant mice on the B6 background.

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Section: Resultssupporting

confidence: 72%

CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection

Patel

Yokoyama

2017

The Journal of Immunology

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“…Survey data were collected via telephone interviews by trained, multilingual AI staff; the response rate was 37%. Although the response rate of 37% is relatively low for an epidemiologic study, it is similar to or higher than the response rate in published health surveys of Asians, Asian Indians, or immigrant ethnic groups [ 12 , 31 ]. The possible reasons for a 37% response rate might be (a) voluntary participation; (b) reluctance to divulge personal information and provide fasting serum blood; (c) not attributing any value to research studies that require time to complete surveys and fasting blood work; (d) ability to understand the purpose and benefits of the study; and (d) barriers associated with confidentiality, trust, and safety.…”

Section: Methodsmentioning

confidence: 65%

“…The sample consisted of 1038 randomly selected Asian Indians, aged 18 years and older, from seven US cities—Houston, TX; Phoenix, AZ; Washington, DC; Boston, MA; San Diego, CA; Edison, NJ; and Parsippany, NJ. The sampling procedure and data collection methodology were reported in prior publications [ 12 , 31 ]. Participation was voluntary.…”

Section: Methodsmentioning

confidence: 99%

Vegetarian Diet and Cardiometabolic Risk among Asian Indians in the United States

Misra

Balagopal²,

Raj³

et al. 2018

Journal of Diabetes Research

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Research studies have shown that plant-based diets confer cardiovascular and metabolic health benefits. Asian Indians (AIs) in the US (who have often followed plant-based diets) have elevated risk for chronic diseases such as diabetes, metabolic syndrome, and obesity suggesting ethnic vulnerability that imply genetic and/or lifestyle causative links. This study explored the association between this ethnic group and diabetes, obesity, and metabolic syndrome after controlling for demographics, acculturation, family history of diabetes, and lifestyle and clinical risk factors. The sample comprised of 1038 randomly selected adult AIs in seven US sites. Prevalence and metabolic syndrome was estimated, and obesity was calculated using the WHO Asian criteria. Multivariate analysis included multinomial logistic regression. The mean age and length of residency in the US were 47 and 18.5 years, respectively. The majority of respondents were vegetarians (62%) and educated. A vegetarian lifestyle was associated with females, food label users, respondents with poor/fair current health status, less acculturated, and those who reported their diet had not changed after coming to the US. Vegetarian status was a protective factor and lowered the risk for diabetes but not for metabolic syndrome and obesity in the regression model. Results provide a firm basis for educational programs.

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“…Low HDL (99.9%) was a common abnormality amongst women and the least common abnormality amongst males (10%). The prevalence of low HDL amongst Asian Indians has been validated by various studies (17) (18). Low HDL is a strong predictor of MI and stroke and is strongly associated with wish CAD.…”

Section: Discussionmentioning

confidence: 98%

A study of metabolic syndrome and its association with demographic, anthropometric and biochemical parameters

Jaseem¹,

Abraham²,

Kumar³

et al. 2021

Biomedicine

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Introduction and Aim: Metabolic syndrome (Mets) is a constellation of interrelated metabolic rearrangements like obesity, hypertension,hyperglycemia,and dyslipidemia whichcan predispose to a greater risk of developing cardiovascular events. This study is aimed to assess the demographic profile of Mets in rural Calicut of Southern India. Materials and Methods:This study was carried outover a period of one year in a tertiary care teaching hospital. Anthropometric measurements (height, weight, waist circumference) and bloodpressure were taken. Fasting blood samples were analyzed to measure glucose, triglyceride, high-density lipoprotein cholesterol and thyroid-stimulating hormone. Results: Out of the randomly selected 650 patients, 347 (53.3%) were males and 303(46.6%) were females,adopting the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP ATP III)Mets was more prevalent infemales than in men (34.32% v/s 14.12 %). Maximum numbers of Mets cases were in the age range of 50–59 years followed by 40–49 years. Among the 153 cases of Mets,decreased high-density lipoproteinwas the most common (99 %) among females and hyperglycemia (51%) among males. Conclusion: The prevalence of MetSin the <50years’ age group is rapidly increasing. It's high time to be more active physically beforethe onset of any fatal cardiovascular events.

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Risk factors for low high-density lipoprotein among Asian Indians in the United States

Cited by 5 publications

References 36 publications

CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection

CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection

Vegetarian Diet and Cardiometabolic Risk among Asian Indians in the United States

A study of metabolic syndrome and its association with demographic, anthropometric and biochemical parameters

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