Risk factors for &lt;I&gt;Mycobacterium tuberculosis&lt;/I&gt; infection in Indonesian children living with a sputum smear-positive case

Rutherford, Merrin; Hill, Philip C.; Maharani, Winni; Apriani, Lika; Sampurno, Hedy; Crevel, Reinout van; Ruslami, Rovina

doi:10.5588/ijtld.12.0389

Cited by 31 publications

(38 citation statements)

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“…The remaining 54 records (53 unique studies) were considered relevant to the review since the previous NICE clinical guidance work in 2011 (CG117). 10 One study by Rutherford et al 110,111 was presented in two publications. In addition, 37 studies from CG117 10 were included in the current evidence synthesis (see Appendix 5).…”

Section: Number Of Studies Identifiedmentioning

confidence: 99%

“…This section included 27 studies (28 publications [102][103][104][105][106][107][108][109][110][111][112][113]148,[150][151][152]154,[156][157][158][159][160][161][162][163][164][165][166] ) in children and adolescents, of which 11 studies 156-166 had already been reviewed in CG117 10 (see Appendix 5). Our searches identified 16 additional studies (in 17 publications [102][103][104][105][106][107][108][109][110][111][112][113]148,[150][151][152]154 ), five [102][103][104]150,152 of which investigated the incidence of active TB following testing for LTBI (incidence studies) and 11 of which (in 12 publications [105]…”

Section: Description Of Baseline Characteristicsmentioning

confidence: 99%

“…Our searches identified 16 additional studies (in 17 publications [102][103][104][105][106][107][108][109][110][111][112][113]148,[150][151][152]154 ), five [102][103][104]150,152 of which investigated the incidence of active TB following testing for LTBI (incidence studies) and 11 of which (in 12 publications [105][106][107][108][109][110][111][112][113]148,151,154 ) investigated levels of exposure in relation to LTBI test outcomes (exposure studies). Two publications 110,111 reported data on the same population and were therefore considered as one study. See Appendix 9 for the full data-extraction sheets for all new included studies.…”

Section: Description Of Baseline Characteristicsmentioning

confidence: 99%

“…This analysis included 17 studies: six studies 156,157,160,162-164 from CG117 10 (see Appendix 5) and 11 studies [105][106][107][108][109][110][111][112][113]148,151,154 from the updated review (see Appendix 9). The association between the screening test results and the risk of LTBI/exposure level measured using the R-DORs (IGRA vs. TST) in individual studies ranged from 0.27 105 to 11.01 113 ( Table 7).…”

Section: Ratios Of Diagnostic Odds Ratiosmentioning

confidence: 99%

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Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation

Auguste

Tsertsvadze

Pink

et al. 2016

Health Technol Assess

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BackgroundTuberculosis (TB), caused byMycobacterium tuberculosis(MTB) [(Zopf 1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly one-third of the world’s population is infected with MTB; TB has an annual incidence of 9 million new cases and each year causes 2 million deaths worldwide.ObjectivesTo investigate the clinical effectiveness and cost-effectiveness of screening tests [interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs)] in latent tuberculosis infection (LTBI) diagnosis to support National Institute for Health and Care Excellence (NICE) guideline development for three population groups: children, immunocompromised people and those who have recently arrived in the UK from high-incidence countries. All of these groups are at higher risk of progression from LTBI to active TB.Data sourcesElectronic databases including MEDLINE, EMBASE, The Cochrane Library and Current Controlled Trials were searched from December 2009 up to December 2014.Review methodsEnglish-language studies evaluating the comparative effectiveness of commercially available tests used for identifying LTBI in children, immunocompromised people and recent arrivals to the UK were eligible. Interventions were IGRAs [QuantiFERON®-TB Gold (QFT-G), QuantiFERON®-TB Gold-In-Tube (QFT-GIT) (Cellestis/Qiagen, Carnegie, VA, Australia) and T-SPOT.TB(Oxford Immunotec, Abingdon, UK)]. The comparator was TST 5 mm or 10 mm alone or with an IGRA. Two independent reviewers screened all identified records and undertook a quality assessment and data synthesis. A de novo model, structured in two stages, was developed to compare the cost-effectiveness of diagnostic strategies.ResultsIn total, 6687 records were screened, of which 53 unique studies were included (a further 37 studies were identified from a previous NICE guideline). The majority of the included studies compared the strength of association for the QFT-GIT/G IGRA with the TST (5 mm or 10 mm) in relation to the incidence of active TB or previous TB exposure. Ten studies reported evidence on decision-analytic models to determine the cost-effectiveness of IGRAs compared with the TST for LTBI diagnosis. In children, TST (≥ 5 mm) negative followed by QFT-GIT was the most cost-effective strategy, with an incremental cost-effectiveness ratio (ICER) of £18,900 per quality-adjusted life-year (QALY) gained. In immunocompromised people, QFT-GIT negative followed by the TST (≥ 5 mm) was the most cost-effective strategy, with an ICER of approximately £18,700 per QALY gained. In those recently arrived from high TB incidence countries, the TST (≥ 5 mm) alone was less costly and more effective than TST (≥ 5 mm) positive followed by QFT-GIT or T-SPOT.TBor QFT-GIT alone.LimitationsThe limitations and scarcity of the evidence, variation in the exposure-based definitions of LTBI and heterogeneity in IGRA performance relative to TST limit the applicability of the review findings.ConclusionsGiven the current evidence, TST (≥ 5 mm) negative followed by QFT-GIT for children, QFT-GIT negative followed by TST (≥ 5 mm) for the immunocompromised population and TST (≥ 5 mm) for recent arrivals were the most cost-effective strategies for diagnosing LTBI that progresses to active TB. These results should be interpreted with caution given the limitations identified. The evidence available is limited and more high-quality research in this area is needed including studies on the inconsistent performance of tests in high-compared with low-incidence TB settings; the prospective assessment of progression to active TB for those at high risk; the relative benefits of two-compared with one-step testing with different tests; and improved classification of people at high and low risk for LTBI.Study registrationThis study is registered as PROSPERO CRD42014009033.FundingThe National Institute for Health Research Health Technology Assessment programme.

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Section: Number Of Studies Identifiedmentioning

confidence: 99%

Section: Description Of Baseline Characteristicsmentioning

confidence: 99%

Section: Description Of Baseline Characteristicsmentioning

confidence: 99%

Section: Ratios Of Diagnostic Odds Ratiosmentioning

confidence: 99%

See 2 more Smart Citations

Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation

Auguste

Tsertsvadze

Pink

et al. 2016

Health Technol Assess

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“…Pulmonary tuberculosis (PTB) is predominantly responsible for TB transmission in human populations [7,8]. Prevalence and known risk factors for PTB among HIV-infected adults vary from one setting to another [5,9,10].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Pulmonary Tuberculosis-HIV Co-Infection in Treatment-Naive Adults in Jos, North Central Nigeria

Agbaji¹,

Ebonyi²,

St³

et al. 2013

J AIDS Clin Res

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Current Epidemiology of Pediatric Tuberculosis

Mane,

Shrotriya

2023

Indian J Pediatr

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Risk factors for <I>Mycobacterium tuberculosis</I> infection in Indonesian children living with a sputum smear-positive case

Abstract: M. tuberculosis infection according to either test was high, supporting screening and preventive treatment. Children of smear-positive TB cases who accompany their parents to the clinic should be prioritised for immediate screening.

Cited by 31 publications

References 14 publications

Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation

Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation

Factors Associated With Pulmonary Tuberculosis-HIV Co-Infection in Treatment-Naive Adults in Jos, North Central Nigeria

Current Epidemiology of Pediatric Tuberculosis

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