Risk factors for lymphoedema in women with breast cancer: A large prospective cohort

Kilbreath, Sharon L.; Refshauge, Kathryn M.; Beith, Jane; Ward, Leigh C.; Ung, Owen; Dylke, Elizabeth; French, James; Yee, Jasmine; Koelmeyer, Louise; Gaitatzis, Katrina

doi:10.1016/j.breast.2016.04.011

Cited by 137 publications

(112 citation statements)

References 39 publications

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“…Systematic reviews suggest that more than one in five women who survive breast cancer will develop arm lymphedema (6). BCRL can be described as the excessive accumulation of protein-rich fluid in interstitial tissue of the arm, hand, and/or chest wall that can occur after breast cancer surgery or radiation therapy (7). This chronic and incurable condition causes physical and psychological disorders.…”

Section: Introductionmentioning

confidence: 99%

Translation and Validation of the Turkish Version of Lymphedema Quality of Life Tool (LYMQOL) in Patients with Breast Cancer Related Lymphedema

Bakar¹,

Tuğral²,

Özdemir³

et al. 2017

Eur J Breast Health

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Objective: Breast cancer related lymphedema (BCRL) is a drastic situation that affects patients who have undergone breast cancer surgery. The impact of this condition on individuals' quality of life should be investigated in more detail to obtain better treatment results. Materials and Methods:In total, 65 patients with BCRL participated in this study. Nottingham Health Profile (NHP) was used to evaluate the validity of associated domains in Lymphedema Quality of Life Tool (LYMQoL). Both the LYMQoL and NHP were filled out by BCRL patients. To evaluate its test-retest reliability, the LYMQoL was subsequently performed seven days following its initial application. Measurement properties such as internal consistency, test-retest reliability, criterion validity and factor structure were tested. The internal consistency was assessed via Cronbach's alpha; test-retest reliability was assessed by the intra-class correlation coefficient (ICC). Results:Cronbach's alpha values ranged from 0.74 to 0.91 for the LYMQoL total and domain scores. Test-retest reliability was excellent (ICC=0.92-0.99). When the relation between LYMQoL and NHP was investigated, 'good' to 'very good' correlations were obtained (r=0.539-0.643, p<0.05) for all domains of LYMQoL. Exploratory factor analyses demonstrated a four-factor structure. Conclusion:Turkish version of LYMQoL is a valid and reliable measurement tool to evaluate the quality of life in patients with BCRL.

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Section: Introductionmentioning

confidence: 99%

Translation and Validation of the Turkish Version of Lymphedema Quality of Life Tool (LYMQOL) in Patients with Breast Cancer Related Lymphedema

Bakar¹,

Tuğral²,

Özdemir³

et al. 2017

Eur J Breast Health

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“…Despite early detection can improve BCRL patients' outcome, the preventive options available to date are extremely limited (54). The physical disruption of the arm lymphatics, such as in case of axillary lymph node dissection (ALND), is a well-established determinant of BCRL (55).…”

Section: Risk Stratification: Who Is Likely To Develop Bcrl?mentioning

confidence: 99%

Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema

et al. 2020

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Breast cancer-related lymphedema (BCRL) occurs in a significant number of breast cancer survivors as a consequence of the axillary lymphatics' impairment after therapy (mainly axillary surgery and irradiation). Despite the recent achievements in the clinical management of these patients, BCRL is often diagnosed at its occurrence. In most cases, it remains a progressive and irreversible condition, with dramatic consequences in terms of quality of life and on sanitary costs. There are still no validated pre-surgical strategies to identify individuals that harbor an increased risk of BCRL. However, clinical, therapeutic, and tumor-specific traits are recurrent in these patients. Over the past few years, many studies have unraveled the complexity of the molecular and transcriptional events leading to the lymphatic system ontogenesis. Additionally, molecular insights are coming from the study of the germline alterations involved at variable levels in BCRL models. Regrettably, there is a substantial lack of predictive biomarkers for BCRL, given that our knowledge of its molecular milieu remains extremely puzzled. The purposes of this review were (i) to outline the biology underpinning the ontogenesis of the lymphatic system; (ii) to assess the current state of knowledge of the molecular alterations that can be involved in BCRL pathogenesis and progression; (iii) to discuss the present and shortterm future perspectives in biomarker-based patients' risk stratification; and (iv) to provide practical information that can be employed to improve the quality of life of these patients.

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“…There are approximately 20 to 40 lymph nodes in the axillary region . For breast cancer patients, the more lymph nodes the surgeon removes, the greater the risk for patients to develop lymphedema . A systematic review and meta‐analysis found that the incidence of lymphedema in the upper extremities is approximately four times greater after axillary lymph node dissections than sentinel node biopsies .…”

Section: Lymphedemamentioning

confidence: 99%

Lymphedema and Lymphovenous Bypass: Perioperative Nursing Implications

Whitnell¹

2020

AORN Journal

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Lymphedema—the accumulation of fluid in tissues, usually in the upper and lower extremities—often results from lymph node dissection or radiation and can cause painful and debilitating swelling that may interfere with a patient's daily living activities and quality of life. The goal of treatment for lymphedema is to reduce the volume of fluid in the affected area. Lymphedema is staged according to presenting characteristics, and interventions may be surgical or nonsurgical, such as complex decongestive therapy. Lymphovenous bypass is a surgical procedure performed for the management of lymphedema and involves rerouting microvascular channels to allow for the drainage of fluid that has accumulated in the lymphatic tissue of the upper or lower extremities. It requires supermicrosurgery techniques because of the small size of the vessels being anastomosed. Perioperative nursing implications for lymphovenous bypass include OR preparation and providing emotional support for patients living with lymphedema.

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Risk factors for lymphoedema in women with breast cancer: A large prospective cohort

Cited by 137 publications

References 39 publications

Translation and Validation of the Turkish Version of Lymphedema Quality of Life Tool (LYMQOL) in Patients with Breast Cancer Related Lymphedema

Translation and Validation of the Turkish Version of Lymphedema Quality of Life Tool (LYMQOL) in Patients with Breast Cancer Related Lymphedema

Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema

Lymphedema and Lymphovenous Bypass: Perioperative Nursing Implications

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