Risk Factors for Metachronous Colorectal Cancer or Advanced Adenomas After Endoscopic Resection of High-risk Adenomas

Baile-Maxía, Sandra; Mangas-Sanjuán, Carolina; Ladabaum, Uri; Hassan, Cesare; Rutter, Matthew D.; Bretthauer, Michael; Medina-Prado, Lucía; Sala-Miquel, Noelia; Pomares, Óscar Murcia; Zapater, Pedro; Jover, Rodrigo

doi:10.1016/j.cgh.2022.12.005

Cited by 16 publications

(3 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Study further proposed that tumor size ≥50 mm was a risk factor for poor prognosis of CRC patients after surgery [30]. Another study showed that patients with baseline adenomas with ≥20 mm had a higher risk of metachronous CRC [31]. It's similar to the ndings of the above researches that the primary tumor size is also a risk factor in our study, which is related to a worse prognosis.…”

Section: Discussionsupporting

confidence: 88%

A predictive model for identifying patients with colorectal cancer from benign polyps based on the serum PLR and PLR-CEA-CA199 score

Cai,

Chen,

Qiu

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Inflammatory responses play an important role in tumor initiation, invasion and metastasis. Platelet-to-lymphocyte ratio (PLR) can reflect systemic inflammation of colorectal cancer (CRC), CEA and CA199 have been known as the simple diagnostic tumor biomarkers for CRC. This study aims to investigate the diagnostic values of PLR, construct a novel PLR-CEA-CA199 (PCC) score, and develop a predictive model for identifying patients with CRC from benign polyps. Methods A total of 333 patients with CRC and 461 patients with benign polyps were selected as subjects retrospectively. The diagnostic performances of PLR and PCC score were estimated by receiver operating characteristic curve (ROC). Univariate and multivariate logistic regression analyses were used to determine risk predictors for the identification of CRC. Finally, a predictive model was established, and whose predictive efficacy was evaluated. Results Results showed that PLR levels and PCC score were significantly different between CRC and benign polyps (P < 0.05). ROC curve analysis showed the diagnostic predictive efficacy of PCC score (AUC = 0.735) was superior to PLR, CEA, CA199, CEA-CA199 (CCI) and PLR-CEA(PCI) score. Multivariate logistic regression analysis showed that four valid parameters including age, maximum tumor size, white blood cell counts (WBC) and PCC score, were suitable to construct a diagnostic predictive model for the identification of CRC (AUC = 0.970, Sen = 90.0%, and Spe = 96.6%). Moreover, the predictive efficacy is also remarkable in distinguishing the advanced CRC from early-stage CRC (AUC = 0.892, Se = 91.0%, and Sp = 78.6%). Conclusions PCC score is an effective indicator to distinguish CRC from benign polyps. Additionally, the predictive model based on four parameters (Age, Maximum tumor size, WBC and PPC score) shows excellent accuracy in identifying patients with CRC from benign polyps, and patients with the advanced CRC from early-stage CRC.

show abstract

Section: Discussionsupporting

confidence: 88%

A predictive model for identifying patients with colorectal cancer from benign polyps based on the serum PLR and PLR-CEA-CA199 score

Cai,

Chen,

Qiu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The third and fourth questions are which adenomas should we chase and what else needs to be done? The relevance of small adenomas has been doubted by many database analyses in the past 10 years, which correlated patients' prognoses with the stage of adenomas found and removed during colonoscopy, and was reconfirmed in a large review at the end of 2022 [51]. Another recent meta-analysis summarized the evidence of 12 such studies [52].…”

mentioning

confidence: 99%

Artificial intelligence and the push for small adenomas: all we need?

Zimmermann-Fraedrich

Rösch

2023

Endoscopy

View full text Add to dashboard Cite

“…B. familiäres Darmkrebsrisiko) nicht identifiziert und überwacht werden 5 6 . Deswegen haben Patienten mit fortgeschrittenen Adenomen immer noch eine deutlich schlechtere Prognose als solche mit kleinen Adenomen oder normaler Koloskopie 7 .…”

unclassified

Positionspapier der Stiftung LebensBlicke 2023

2023

Z Gastroenterol

View full text Add to dashboard Cite

Risk Factors for Metachronous Colorectal Cancer or Advanced Adenomas After Endoscopic Resection of High-risk Adenomas

Cited by 16 publications

References 79 publications

A predictive model for identifying patients with colorectal cancer from benign polyps based on the serum PLR and PLR-CEA-CA199 score

A predictive model for identifying patients with colorectal cancer from benign polyps based on the serum PLR and PLR-CEA-CA199 score

Artificial intelligence and the push for small adenomas: all we need?

Positionspapier der Stiftung LebensBlicke 2023

Contact Info

Product

Resources

About