Risk Factors for Mild Cognitive Impairment, Dementia and Mortality: The Sydney Memory and Ageing Study

Lipnicki, Darren M.; Crawford, John D.; Kochan, Nicole A.; Trollor, Julian N.; Draper, Brian; Reppermund, Simone; Maston, Kate; Mather, Karen A.; Brodaty, Henry; Sachdev, Perminder S.; Bowman, Allison; Burns, Kimberly; Broe, Anthony; Dekker, Joula; Dooley, Louise; Permentier, Michele de; Fairjones, Sarah; Fletcher, Janelle; French, Therese; Foster, Catherine; Nugent-Cleary-Fox, Emma; Gooi, Chien Hoong; Harvey, Evelyn; Helyer, Rebecca; Hsieh, Sharpley; Hughes, Laura E.; Jacek, Sarah; Johnston, Mary C. Deirdre; Kang, Kristan; McCade, Donna; Meeth, Samantha; Milne, Eveline; Moir, Angharad; O'Grady, Ros; Pfaeffli, Kia; Pose, Carine; Reuser, Laura; Rose, Amanda F.; Schofield, Peter R.; Shahnawaz, Zeeshan; Sharpley, Amanda; Slavin, Melissa J.; Thompson, Claire; Queisser, Wiebke; Wong, Sophia

doi:10.1016/j.jamda.2016.10.014

Cited by 64 publications

(41 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We also found that none of the comorbidities had any association with cognitive impairment. This finding is contradictory with those of the previous studies, which showed that hypertension, diabetes mellitus, stroke, and CVD were associated with a higher risk of cognitive impairment [61][62][63]. This discrepancy might be due to most of the history of comorbidities in the present study were self-reported.…”

Section: Discussioncontrasting

confidence: 99%

Obesity Is Less Frequently Associated with Cognitive Impairment in Elderly Individuals: A Cross-Sectional Study in Yogyakarta, Indonesia

et al. 2020

View full text Add to dashboard Cite

Obesity is one of the factors associated with cognitive impairment. However, obesity may differently affect cognitive function in different age groups, and scarce data are available from low- and middle-income countries. This cross-sectional study aimed to identify the association between obesity and cognitive impairment among 143 elderly individuals in Yogyakarta. We recorded the sociodemographic factors and some comorbidities, also measured the body mass index as a parameter of obesity, cognitive function using Montreal Cognitive Assessment—Indonesia, mood condition and depression status using geriatric depression scale-short form, as well as the daily life function using Activity of Daily Living and Instrumental Activity of Daily Living. After adjustment for the sociodemographic and comorbidities, we found that subjects with older age were more likely to have cognitive impairment (odds ratio [OR] 3.544, 95%CI: 1.36–9.22, p < 0.01) and compared with elderly individuals with normal weight, obese elderly individuals were 40% less likely to have cognitive impairment (OR 0.604, 95%CI: 0.39–0.95, p < 0.05). This study suggests that obesity in elderly individuals is less frequently associated with cognitive impairment. These findings support the reverse causation mechanism related to body mass index (BMI) and cognitive impairment in low/middle-income countries.

show abstract

Section: Discussioncontrasting

confidence: 99%

Obesity Is Less Frequently Associated with Cognitive Impairment in Elderly Individuals: A Cross-Sectional Study in Yogyakarta, Indonesia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These results were consistent with FNIH-defined sarcopenia and EWGSOP2-defined sarcopenia. Our findings regarding the association between cognitive impairment and slow gait speed are consistent with those of previous studies [41][42][43][44]. The slow gait speed was considered a noninvasive risk factor for cognitive decline in cognitively normal older adults [42].…”

Section: Discussionsupporting

confidence: 92%

Sarcopenia is Associated Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)

Kim¹,

Won²

2019

Preprint

View full text Add to dashboard Cite

Cognitive impairment and sarcopenia may share common risk factors and pathophysiological pathways. This study was performed to examine the association between impairments in specific cognitive domains and sarcopenia (and its defining components) in a large group of community-dwelling older adults. Cross-sectional analysis was performed on the baseline data of 3,014 adults aged 70–84 years enrolled in the Korean Frailty and Aging Cohort Study (KFACS). The final analysis included 1,887 adults underwent dual-energy X-ray absorptiometry and cognitive function assessments. Those with disability in activities of daily living, dementia, severe cognitive impairment, Parkinson’s disease, musculoskeletal complaints, neurological disorders, or who were illiterate were excluded. Cognitive function was assessed using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet, the Frontal Assessment Battery. For sarcopenia, we used the diagnostic criteria of the Asian Working Group for Sarcopenia. The prevalence of sarcopenia was 9.6% for men and 7.6% for women. Sarcopenia (odds ratio [OR] 1.76, 95% confidence interval [CI] 1.04–2.99) and slow gait speed (OR 2.58, 95% CI 1.34–4.99) were associated with cognitive impairment in men. Only slow gait speed (OR 1.88, 95% CI 1.05–3.36) was associated with cognitive impairment in women. Sarcopenia is associated with cognitive impairment mainly due to slow gait speed. Our results suggested that cognitive impairment domains, such as processing speed and executive function, are associated with sarcopenia-related slow gait speed.

show abstract

“…The selection of variables for the current study was based on the most commonly examined in the literature. In a recent publication, our group has examined a comprehensive range of risk factors for mortality, and also for dementia and Mild Cognitive Impairment [46]. We identified 85 cases with dementia over the follow-up period corresponding to an incidence rate of 19.1/1000 person-years in this older adult community sample.…”

Section: Discussionmentioning

confidence: 99%

Is intraindividual reaction time variability an independent cognitive predictor of mortality in old age? Findings from the Sydney Memory and Ageing Study

Kochan¹,

Bunce²,

Pont³

et al. 2017

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Intraindividual variability of reaction time (IIV RT ), a proposed cognitive marker of neurobiological disturbance, increases in old age, and has been associated with dementia and mortality. The extent to which IIV RT is an independent predictor of mortality, however, is unclear. This study investigated the association of IIV RT and all-cause mortality while accounting for cognitive level, incident dementia and biomedical risk factors in 861 participants aged 70-90 from the Sydney Memory and Ageing Study. Participants completed two computerised reaction time (RT) tasks (76 trials in total) at baseline, and comprehensive medical and neuropsychological assessments every 2 years. Composite RT measures were derived from the two tasks-the mean RT and the IIV RT measure computed from the intraindividual standard deviation of the RTs (with age and time-on-task effects partialled out). Consensus dementia diagnoses were made by an expert panel of clinicians using clinical criteria, and mortality data were obtained from a state registry. Cox proportional hazards models estimated the association of IIV RT and mean RT with survival time over 8 years during which 191 (22.2%) participants died. Greater IIV RT but not mean RT significantly predicted survival time after adjusting for age, sex, global cognition score, cardiovascular risk index and apolipoprotein ε4 status. After excluding incident dementia cases, the association of IIV RT with mortality changed very little. Our findings suggest that greater IIV RT uniquely predicts shorter time to death and that lower global cognition and prodromal dementia in older individuals do not explain this relationship.

show abstract

Risk Factors for Mild Cognitive Impairment, Dementia and Mortality: The Sydney Memory and Ageing Study

Cited by 64 publications

References 51 publications

Obesity Is Less Frequently Associated with Cognitive Impairment in Elderly Individuals: A Cross-Sectional Study in Yogyakarta, Indonesia

Obesity Is Less Frequently Associated with Cognitive Impairment in Elderly Individuals: A Cross-Sectional Study in Yogyakarta, Indonesia

Sarcopenia is Associated Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)

Is intraindividual reaction time variability an independent cognitive predictor of mortality in old age? Findings from the Sydney Memory and Ageing Study

Contact Info

Product

Resources

About