Risk factors for mortality and multidrug resistance in pulmonary tuberculosis in Guatemala: A retrospective analysis of mandatory reporting

Montes, Kevin; Atluri, Himachandana; Tuch, H.; Ramirez, Lucrecia; Paiz, Juan; Lopez, A; Bailey, Thomas C.; Spec, Andrej; Mejía-Chew, Carlos

doi:10.1016/j.jctube.2021.100287

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…Our result echoed previous studies’ findings from developing and developed countries. 38–40 Individuals with a higher level of formal education are associated with positive health-seeking behaviour and compliance with treatment. Furthermore, the education level is a good indicator of a person’s economic situation, which determines one’s capacity to practice healthy living and access health resources if needed.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for tuberculosis-related death among adults with drug-sensitive pulmonary tuberculosis in Selangor, Malaysia from 2013 to 2019: a retrospective cohort study using surveillance data

Suhairi,

Mohamad,

Isa

et al. 2024

BMJ Open

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ObjectivesDue to the paucity of literature on risk factors for tuberculosis (TB)-related death, we determine the sociodemographic and clinical risk factors associated with TB-related deaths among adult pulmonary TB (PTB) patients on treatment in Selangor, Malaysia.DesignRetrospective cohort study.SettingRoutinely collected primary care data from all government TB clinics in Selangor.ParticipantsData of 24 570 eligible adult PTB patients from 2013 to 2019 were obtained from Selangor’s State Health Department surveillance records. We included PTB patients aged at least 15 years old at the time of diagnosis with complete documentation of the dates of diagnosis, treatment initiation, end of treatment/follow-up and treatment outcomes. We excluded patients whose diagnoses were changed to non-TB, post-mortem TB diagnosis and multidrug-resistant TB (MDR-TB) patients.Primary and secondary outcome measuresTB-related death, determined from the recorded physicians’ consensus during the TB mortality meeting.ResultsTB-related death was significantly associated with far (adjusted HR (aHR) 9.98, 95% CI 4.28 to 23.28) and moderately advanced (aHR 3.23, 95% CI 1.43 to 7.31) radiological findings at diagnosis; concurrent TB meningitis (aHR 7.67, 95% CI 4.53 to 12.98) and miliary TB (aHR 6.32, 95% CI 4.10 to 9.74) involvement; HIV positive at diagnosis (aHR 2.81, 95% CI 2.21 to 3.57); Hulu Selangor (aHR 1.95, 95% CI 1.29 to 2.93), Klang (aHR 1.53, 95% CI 1.18 to 1.98) and Hulu Langat (aHR 1.31, 95% CI 1.03 to 1.68) residing districts; no formal education (aHR 1.70, 95% CI 1.23 to 2.35); unemployment (aHR 1.54, 95% CI 1.29 to 1.84), positive sputum smear acid-fast bacilli (AFB) at diagnosis (aHR 1.51, 95% CI 1.22 to 1.85); rural residency (aHR 1.39, 95% CI 1.13 to 1.72) and advancing age (aHR 1.03, 95% CI 1.02 to 1.03).ConclusionsFar and moderately advanced radiological findings, concurrent TB meningitis and miliary TB involvement, HIV positive, Hulu Selangor, Klang and Hulu Langat residing districts, no formal education, unemployment, positive sputum smear AFB, rural residency and advancing age are risk factors of TB-related death. Our findings should assist in identifying high-risk patients requiring interventions against TB-related death.

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Section: Discussionmentioning

confidence: 99%

Risk factors for tuberculosis-related death among adults with drug-sensitive pulmonary tuberculosis in Selangor, Malaysia from 2013 to 2019: a retrospective cohort study using surveillance data

Suhairi,

Mohamad,

Isa

et al. 2024

BMJ Open

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“…In a study from a hospital in Zambia, among the 27 unsuspected TB cases identified 18.5% had history of TB treatment [ 28 ]. Previous TB treatment is associated with increased risk of TB, MDR-TB and mortality [ 32 , 33 ]. We found that pilgrims previously treated for TB were 8 to 10 times more likely to have TB.…”

Section: Discussionmentioning

confidence: 99%

Undiagnosed and missed active pulmonary tuberculosis during mass gatherings: a prospective cross-sectional study from the Hajj pilgrimage

Yezli

Yassin

Mushi

et al. 2023

Eur J Clin Microbiol Infect Dis

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Mass gatherings increase the risk of infectious diseases transmission including tuberculosis (TB). The Hajj pilgrimage to Mecca, Saudi Arabia, is attended by over 2 million pilgrims many of whom are from high TB-burden countries, and has been linked to increased risk of TB acquisition among travellers. We investigated the burden of undiagnosed and missed active pulmonary TB (PTB) among Hajj pilgrims symptomatic for cough. The study was conducted among hospitalised and non-hospitalised travellers attending the Hajj pilgrimage in 2016 and 2017. Questionnaires were used to collect relevant data and sputum samples were collected from participants and processed using the Xpert MTB-RIF assay. Non-hospitalised pilgrims ( n = 1510) originating from 16 high and medium TB-burden countries were enrolled. Undiagnosed, rifampicin-sensitive, active PTB was identified in 0.7%. Comorbidities (adjOR = 5.9 [95% CI = 1.2–27.8]), close contact with a TB case (adjOR = 5.9 [95% CI = 1.2–27.8]), cough in household (adjOR = 4.46 [95% CI = 1.1–19.5]), and previous TB treatment (adjOR = 10.1 [95% CI = 4.1–98.1]) were independent risk factors for TB. Of the hospitalised pilgrims ( n = 304), 2.9% were positive for PTB, and 2.3% were missed, including a rifampicin-resistant case. History of TB treatment was associated with increased risk of TB (adjOR = 8.1 [95% CI = 1.3–48.7]). International mass gatherings may play an important role in the global epidemiology of TB. Preventive measures should be directed to reducing the risk of TB importation and transmission during Hajj and other similar events. Supplementary Information The online version contains supplementary material available at 10.1007/s10096-023-04596-8.

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“…Hal ini menggambarkan tidak adanya pengaruh tingkat pendidikan terhadap angka MDR-TB. Penelitian ini sejalan dengan studi di Guatemala bahwa tingkat pendidikan secara signifikan tidak berpengaruh terhadap kasus MDR-TB hingga kematian akibat MDR-TB 7 . Penelitian di Peru menunjukkan bahwa tingkat pendidikan lebih dikaitkan dengan kejadian kematian akibat MDR-TB jadi tingkat pendidikan rendah secara signifikan berhubungan dengan kejadian kematian akibat MDR-TB 8 .…”

Section: Pembahasanunclassified

Determinan Kejadian Multidrugs ResistenTuberculosis (MDR TB) di Kecamatan Luwuk Utara

Sukmawati,

Galenso

2021

LNJ

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Indonesia termasuk high burden countries, artinya Indonesia memiliki permasalahan besar menghadapi TB. Penelitian bertujuan mengidentifikasi Karakteristik Penderita dan determinan MDR-TB di wilayah Kecamatan Luwuk Utara. Jenis Penelitian Case control study. Teknik sampel dengan total sampling. Analisis data dengan Odds Ratio untuk mengetahui besar peluang variabel beresiko terhadap kejadian kasus MDR-TB. Odds Ratio dengan 95% confidence interval diperoleh bahwa PMO, Dukungan Keluarga, dan Keteraturan Minum Obat adalah 100% sehingga tidak dilanjutkan untuk melihat besarnya peluang beresiko. Pengetahuan merupakan determinan MDR TB dengan nilai OR >0,1. Analisis variabel akses pelayanan menunjukkan nilai OR>1,75 artinya variabel akses pelayanan Kesehatan pada responden memiliki peluang 1,75 lebih besar menderita MDR TD. Penyuluhan Kesehatan diperoleh nilai OR>11 jadi 11,5 lebih berpeluang memiliki risiko MDR-TB. Hasil analisis variabel petugas Kesehatan menunjukkan nilai OR>5,8. Artinya peluang berisiko variabel petugas Kesehatan adalah 5,8 lebih besar menderita MDR-TB. Kesimpulan penelitian adalah Karakteristik MDR TB tertinggi pada usia 17-25 tahun dan 46-55 tahun, jenis kelamin laki-laki, Pendidikan SLTA dan pekerjaan wiraswasta. Hasil analisis Odds Ratio menunjukkan bahwa yang bermakna adalah variabel pengetahuan dimana OR>0,1.

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Risk factors for mortality and multidrug resistance in pulmonary tuberculosis in Guatemala: A retrospective analysis of mandatory reporting

Cited by 6 publications

References 27 publications

Risk factors for tuberculosis-related death among adults with drug-sensitive pulmonary tuberculosis in Selangor, Malaysia from 2013 to 2019: a retrospective cohort study using surveillance data

Risk factors for tuberculosis-related death among adults with drug-sensitive pulmonary tuberculosis in Selangor, Malaysia from 2013 to 2019: a retrospective cohort study using surveillance data

Undiagnosed and missed active pulmonary tuberculosis during mass gatherings: a prospective cross-sectional study from the Hajj pilgrimage

Determinan Kejadian Multidrugs ResistenTuberculosis (MDR TB) di Kecamatan Luwuk Utara

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