Risk factors for mortality due to natural causes and suicide among people with severe mental illness in western China

Liu, Xiang; Yang, Xianmei; Wang, Dan; Fan, Ruoxin; Rong-ke, Wang; Huang, Xiang; Li, Jun; Liu, Yuanyuan

doi:10.1016/j.psychres.2023.115108

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…We contacted the authors of 60 articles in which estimates were adjusted for SEP or combined suicides and suicides attempts and were based on different populations to request additional data; 37 replied, 9 of whom provided unpublished data . Four of 4511 articles identified from the snowball search and 4 of 2386 articles from updating the database search were additionally included . In total, we included 71 studies totaling more than 4 million people with mental disorders (Figure 1; eTable 5 in Supplement 1).…”

Section: Resultsmentioning

confidence: 99%

The Role of Socioeconomic Position in the Association Between Mental Disorders and Mortality

Chen,

Ejlskov,

Laustsen

et al. 2024

JAMA Psychiatry

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ImportanceStudies are lacking summarizing how the association between mental disorders and mortality varies by socioeconomic position (SEP), particularly considering different aspects of SEP, specific types of mental disorders, and causes of death.ObjectiveTo investigate the role of SEP in the association between mental disorders and mortality and the association between SEP and mortality among people with mental disorders.Data SourcesMEDLINE, Embase, PsycINFO, and Web of Science were searched from January 1, 1980, through April 3, 2023, and a snowball search of reference and citation lists was conducted.Study SelectionInclusion criteria were observational studies estimating the associations between different types of mental disorders and mortality, stratified by SEP and between SEP and mortality in people with mental disorders.Data Extraction and SynthesisPairs of reviewers independently extracted data using a predefined data extraction form and assessed the risk of bias using the adapted Newcastle-Ottawa scale. Graphical analyses of the dose-response associations and random-effects meta-analyses were performed. Heterogeneity was explored through meta-regressions and sensitivity analyses.Main Outcomes and MeasuresAll-cause and cause-specific mortality.ResultsOf 28 274 articles screened, 71 including more than 4 million people with mental disorders met the inclusion criteria (most of which were conducted in high-income countries). The relative associations between mental disorders and mortality were similar across SEP levels. Among people with mental disorders, belonging to the highest rather than the lowest SEP group was associated with lower all-cause mortality (pooled relative risk [RR], 0.79; 95% CI, 0.73-0.86) and mortality from natural causes (RR, 0.73; 95% CI, 0.62-0.85) and higher mortality from external causes (RR, 1.18; 95% CI, 0.99-1.41). Heterogeneity was high (I2 = 83% to 99%). Results from subgroup, sensitivity, and meta-regression analyses were consistent with those from the main analyses. Evidence on absolute scales, specific diagnoses, and specific causes of death was scarce.Conclusion and RelevanceThis study did not find a sufficient body of evidence that SEP moderated the relative association between mental disorders and mortality, but the underlying mortality rates may differ by SEP group, despite having scarcely been reported. This information gap, together with our findings related to SEP and a possible differential risk between natural and external causes of death in individuals with specific types of mental disorders, warrants further research.

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Section: Resultsmentioning

confidence: 99%

The Role of Socioeconomic Position in the Association Between Mental Disorders and Mortality

Chen,

Ejlskov,

Laustsen

et al. 2024

JAMA Psychiatry

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“…Then a higher prevalence was observed among the general population during the pandemic [4] , [5] . As a result, there has been an extensively reported increase in mortality, as well as an increase in suicide cases [6] , [7] . China has made plans to help people with mental health, but some of them haven't been fully implemented yet [8] .…”

Section: Introductionmentioning

confidence: 99%

Somatized or stigma? Causal attributions and emotional responses in shaping social distance towards people with mental illness, China

Zeng

2024

Heliyon

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Clinical factors for all-cause mortality in people with schizophrenia: a retrospective cohort study between 2013 and 2021

Pan,

Zhou,

Chen

et al. 2024

Asian Journal of Psychiatry

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Risk factors for mortality due to natural causes and suicide among people with severe mental illness in western China

Cited by 5 publications

References 38 publications

The Role of Socioeconomic Position in the Association Between Mental Disorders and Mortality

The Role of Socioeconomic Position in the Association Between Mental Disorders and Mortality

Somatized or stigma? Causal attributions and emotional responses in shaping social distance towards people with mental illness, China

Clinical factors for all-cause mortality in people with schizophrenia: a retrospective cohort study between 2013 and 2021

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