Risk factors for mortality in elderly haemodialysis patients: a systematic review and meta-analysis

Song, Yiwei; Cai, Guangyan; Xiao, Yijun; Chen, Xiangmei

doi:10.1186/s12882-020-02026-x

Cited by 46 publications

(45 citation statements)

References 49 publications

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“…According to a recent, nationwide cohort study [ 13 ], hemodialysis patients had a lower adjusted risk of death compared with those on peritoneal dialysis. However, the hemodialysis patients still have higher mortality as well as multimorbidity and hospitalizations than the general population [ 14 ]. According to previous studies, several factors such as age, presence of diabetes mellitus, history of cardiovascular events, and elevated high-sensitivity C-reactive protein were reported as risk factors for mortality in hemodialysis patients [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the hemodialysis patients still have higher mortality as well as multimorbidity and hospitalizations than the general population [ 14 ]. According to previous studies, several factors such as age, presence of diabetes mellitus, history of cardiovascular events, and elevated high-sensitivity C-reactive protein were reported as risk factors for mortality in hemodialysis patients [ 14 , 15 , 16 ]. However, the risk factors for mortality in ESRD patients undergoing hemodialysis are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Lee

Son

2021

IJERPH

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Hemodialysis is the most common type of treatment for end-stage renal disease (ESRD). Frailty is associated with poor outcomes such as higher mortality. ESRD patients have a higher prevalence of frailty. This systematic review and meta-analysis aimed to identify the prevalence and associated factors of frailty and examine whether it is a predictor of mortality among ESRD patients undergoing hemodialysis. Five electronic databases including PubMed, Embase, CINAHL, Web of Science, and Cochrane Library were searched for relevant studies up to 30 November 2020. A total of 752 articles were found, and seven studies with 2604 participants in total were included in the final analysis. The pooled prevalence of frailty in patients with ESRD undergoing hemodialysis was 46% (95% Confidence interval (CI) 34.2−58.3%). Advanced age, female sex, and the presence of diabetes mellitus increased the risk of frailty in ESRD patients undergoing hemodialysis. Our main finding showed that patients with frailty had a greater risk of all-cause mortality compared with those without (hazard ratio (HR): 2.02, 95% CI: 1.65−2.48). To improve ESRD patient outcomes, healthcare professionals need to assess the frailty of older ESRD patients, particularly by considering gender and comorbidities. Comprehensive frailty screening tools for ESRD patients on hemodialysis need to be developed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Lee

Son

2021

IJERPH

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“…Previous studies have related these events with falls, and this study directly demonstrated that intradialytic weight change is a factor related to the risk of falls. Falls are factors of poor prognosis in patients who receive dialysis ( 14 ) and after observing an incidence of falls of 32%, similar to the 37% described in a recent study ( 23 ) , it would be interesting to analyze the ability to prevent falls in patients whose intradialytic weight change is greater than 1.9 kg via prevention protocols.…”

Section: Discussionmentioning

confidence: 80%

“…Consequently, numerous factors may place HD patients’ postural control at risk. Preventing falls in HD patients is essential, because the consequences in terms of quality of life, associated morbidity and reduction in life expectancy are very important ( 13 - 14 ) . The nursing staff in charge of our dialysis unit is responsible for connecting, supervising and disconnecting the dialyzed patient.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with falls in hemodialysis patients: a case-control study

Pérez-Gurbindo

Álvarez-Méndez

Pérez‐García

et al. 2021

Rev. Latino-Am. Enfermagem

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Objective: to identify possible associations between a higher probability of falls among hemodialysis patients and laboratory values, comorbidities, pharmacological treatment, hemodynamic changes, dialysis results and stabilometric alterations. Method: this was a retrospective case-control study with hemodialysis patients. Patients in a hemodialysis unit who had suffered one or more falls were included in the case group. Patients from the same unit who had not suffered falls were the controls. Data were gathered from the patients’ clinical history and also from the results of a balance test conducted six months before the study. Results: thirty-one patients were included (10 cases and 21 controls). Intradialytic body weight change was significantly greater among cases (p <0.05). Patients in the case group also presented greater lateral instability after dialysis (p <0.05). Other factors such as high blood pressure, antihypertensives, beta-blockers, and lower heart rates were also associated with falls. Conclusion: a greater intradialytic weight change was associated with an increase in risk of falls. Nursing staff can control these factors to prevent the incidence of falls in dialysis patients.

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“…Penelitian lainnya oleh Song, dkk. 20 menunjukkan bahwa gangguan kognitif dan jatuh pada lansia yang menjalani hemodialisis sangat berhubungan dengan risiko kematian. Sedangkan, pada penelitian ini tidak dilakukan penilaian gangguan kognitif dan asesmen jatuh pada pasien.…”

Section: Diskusiunclassified

Peran Gejala Depresi sebagai Faktor Prediktor Kematian dalam Enam Bulan pada Lansia yang Menjalani Hemodialisis

Perdhana¹,

Chasani²,

Mupangati³

et al. 2022

JPDI

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Pendahuluan. Depresi merupakan gangguan mental yang banyak ditemukan baik pada kelompok lansia maupun pada pasien yang menjalani hemodialisis. Depresi berdampak buruk terhadap kualitas hidup pasien. Penelitian yang menghubungkan depresi sebagai faktor prediktor kematian dalam enam bulan pada lansia yang menjalani hemodialisis belum pernah dilakukan di Indonesia. Penelitian ini bertujuan untuk mengetahui peran gejala depresi sebagai faktor prediktor kematian dalam 6 bulan pada lansia yang menjalani hemodialisis.Metode. Penelitian dengan desain kohort prospektif dilakukan pada Februari – Agustus 2020 di Unit Hemodialisis Rumah Sakit Roemani Muhammadiyah Semarang. Adapun kriteria inklusi meliputi lansia (usia ≥60 tahun), menjalani hemodialisis ≥3 bulan, frekuensi hemodialisis 2 kali seminggu, bersedia mengikuti penelitian, dapat berkomunikasi dengan baik, dan tidak terdapat riwayat gangguan mental sebelumnya yang meliputi riwayat gangguan psikotik, dan gangguan mental akibat penggunaan zat. Sedangkan pasien dengan data tidak lengkap, pindah ke unit hemodialisis lain, HBsAg +, kadar Hemoglobin <7 mg/dl, skor RAPUH >2, dan memiliki stressor lain yang tidak terkait dengan hemodialisis atau Penyakit Ginjal Kronis (PGK) seperti faktor sosial, keluarga, dan pekerjaan dieksklusi dari penelitian ini. Depresi dinilai menggunakan kuesioner Beck Depression Inventory-II yang telah diterjemahkan ke dalam Bahasa Indonesia. Adapun pengisian kuesioner dilakukan oleh responden dengan panduan oleh peneliti dalam proses pengisiannya. Data yang terkumpul kemudian dianalisis menggunakan Kaplan Meier dan Cox Regression menggunakan SPSS 18.0.Hasil. Dari total 32 responden, mayoritas adalah laki-laki yaitu sebanyak 26 responden (81,3%). Rerata usia responden adalah 67,2 (simpang baku [SB] 7) tahun. Sebanyak 6 (18,7%) responden mengalami depresi dan 26 (81,3%) responden tidak mengalami depresi. Hasil analisis Cox Regression menunjukkan bahwa depresi berperan sebagai faktor prediktor kematian dalam 6 bulan pada lansia yang menjalani hemodialisis (p=0.012), dan hazard ratio=10,149.Simpulan. Depresi berperan sebagai faktor prediktor kematian dalam 6 bulan pada lansia yang menjalani hemodialisis.Kata Kunci: Depresi, geriatri, mortalitas, penyakit ginjal kronik, penyakit ginjal tahap akhirDepressive symptoms as a Predictor Factor of All-Cause Mortality within Six Months in Elderly Hemodialysis PatientsIntroduction. Depression is a mental disorder that is often found in the elderly and hemodialysis patients, resulting in bad effects on patients. There is no study on the relationship between depression and all-cause mortality risk in elderly hemodialysis patients in Indonesia. This study aimed to determine the role of depression as a predictor factor of all-cause mortality within 6 months in elderly hemodialysis patients. Methods. A prospective cohort study was conducted from February to August 2020 at the hemodialysis unit of Roemani Muhammadiyah Hospital, Semarang. The inclusion criteria were elderly patients (aged ≥60 years), undergoing hemodialysis ≥3 months, hemodialysis frequency twice a week, willing to participate in this study, able to communicate well, and has no history of mental disorders include a history of psychotic disorders and mental disorders due to substance use. Meanwhile, patients whose data were incomplete, transferred to another hemodialysis unit, HBsAg +, hemoglobin level <7 mg/dl. FRAILTY score >2, and had other stressors not related to hemodialysis or chronic kidney disease (CKD) such as social, family, and work factors were excluded from this study. Depression was assessed using the Beck Depression Inventory-II questionnaire. The collected data was then analyzed using Kaplan Meier and Cox Regression.Results. Of 32 respondents, most of them were male (81.3%). The mean age was 67.2 (SD 7) years. There were 6 (18.7%) respondents categorized into a depression group and 26 (81.3%) respondents into a non-depression group. Cox Regression analysis showed that depression was a predicting factor of all-cause mortality within six months in elderly hemodialysis patients (p value=0.012, and Hazard ratio=10.149). Conclusion. Depression is a predictor factor of all-cause mortality within six months in elderly hemodialysis patients.

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Risk factors for mortality in elderly haemodialysis patients: a systematic review and meta-analysis

Cited by 46 publications

References 49 publications

Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Factors associated with falls in hemodialysis patients: a case-control study

Peran Gejala Depresi sebagai Faktor Prediktor Kematian dalam Enam Bulan pada Lansia yang Menjalani Hemodialisis

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