Risk factors for multidrug resistance among previously treated patients with tuberculosis in eastern China: a case–control study

Chen, Songhua; Huai, Pengcheng; Zhong, Jieming; Wang, Xinting; Wang, Kai; Wang, Lixia; Jiang, Shaobo; Li, Jun; Peng, Ying; Ma, Wei

doi:10.1016/j.ijid.2013.06.006

Cited by 39 publications

(33 citation statements)

References 15 publications

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“…But gender impact on MDR/RR-TB was reported differently in different regions. There was no association with gender in several studies [8-13]. In some regions of China, studies showed that female was more likely to develop MDR/RR-TB [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of drug-resistant tuberculosis in Chongqing, China: a retrospective observational study from 2010 to 2017

et al. 2019

Preprint

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24China is one of the top 30 countries with high multidrug-resistant tuberculosis 2 25 (MDR-TB) and rifampin-resistant tuberculosis (RR-TB) burden. Chongqing is a 26 southwest city of China with a large rural population. A retrospective observational 27 study has been performed based on routine tuberculosis (TB) surveillance data in 28 Chongqing from 2010 to 2017. The MDR/RR-TB notification rate increased from 29 0.03 cases per 100,000 population in 2010 to 2.09 cases per 100,000 population in 30 2017. The extensively drug-resistant TB (XDR-TB) notification rate has increased to 31 0.09 cases per 100,000 population in 2017. There was a decreasing detection gap 32 between the number of notified MDR/RR-TB cases and the estimate number of 33 MDR/RR-TB cases among all notified TB cases. The treatment success rate of 34 MDR/RR-TB was 50.66% in this period. The rate of MDR/RR-TB in new TB cases 35 was 6.23%, and this rate in previously treated TB cases was 32.7%. Despite the 36 progress achieved, the prevalence of MDR/RR-TB was still high facing challenges 37 including detection gaps, the regional disparity, and the high risk for MDR/RR-TB in 38 elderly people and farmers. Sustained government financing and policy support 39 should be guaranteed in the future.40 41 42 Drug-resistant tuberculosis (DR-TB) threatens global TB prevention and control.43 MDR-TB, defined as TB resistant to at least rifampin (RFP) and isoniazid (INH), has 44 longer treatment regimens and lower treatment success rate with supplies of less 45 effective and more toxic second-line drugs [1]. RR-TB, defined as TB resistant to at 46 least RFP, also requires a second-line regimen, and 83% of RR-TB cases have 3 47

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Section: Discussionmentioning

confidence: 99%

Epidemiology of drug-resistant tuberculosis in Chongqing, China: a retrospective observational study from 2010 to 2017

et al. 2019

Preprint

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“…23 Few studies have examined risk factors for primary MDR tuberculosis and the associations that have been reported have been inconsistent. A common finding across multiple studies is that patients with MDR tuberculosis tend to be younger than those with a drug-sensitive infection, 24 with one meta-analysis reporting that patients with tuberculosis younger than 65 years were 2·5 times more likely to have MDR than those who are older than 65 years. 24 A possible explanation for this is that older patients might have tuberculosis due to activation of a latent infection acquired before the emergence of drug resistance.…”

Section: The Lancet Respiratory Medicine Commissionmentioning

confidence: 99%

“…A common finding across multiple studies is that patients with MDR tuberculosis tend to be younger than those with a drug-sensitive infection, 24 with one meta-analysis reporting that patients with tuberculosis younger than 65 years were 2·5 times more likely to have MDR than those who are older than 65 years. 24 A possible explanation for this is that older patients might have tuberculosis due to activation of a latent infection acquired before the emergence of drug resistance. Such data are consistent with findings from molecular epidemiological studies that show that younger age is a risk factor for recent transmission.…”

Section: The Lancet Respiratory Medicine Commissionmentioning

confidence: 99%

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Dheda

Gumbo

Maartens

et al. 2017

The Lancet Respiratory Medicine

533

474

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“…To the contrary, a study in other setting stated that MDR-TB was more prevalent among older age groups 20 . Moreover, regarding socio-economic factors, majority of MDR-TB patients were from low socioeconomic status 2,28,29 . This might be due to poor compliance with TB treatment often due to poor living and housing condition and limited access to medical treatment and health care services which might facilitate the spread of infectious bacilli.…”

mentioning

confidence: 99%

Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State.

Mulu¹,

Mekonnen²,

Yimer³

et al. 2015

Afr H. Sci.

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Background: Multidrug resistant tuberculosis(MDR-TB) is becoming a major threat to tuberculosis control programs in Ethiopia. Objectives: To determine risk factors of MDR-TB patients in Amhara National Regional State, Ethiopia. Methods: Case-control study was conducted from May 2013 to January 2014. Resistance to rifampicin and isoniazid were done molecularly using line probe assay. TB patients infected with MDR-M.tuberculosis and non MDR-M.tuberculosis strain were considered as cases and controls, respectively. Data was collected using structured questionnaire with face to face interview. Patients' clinical record review was also done.Multivariate analysis was computed to determine the risk factors of MDR-TB. Results: A total of 153 MDR-TB and equal number of non MDR-TB patients' participated in the study. Patients who had TB treatment failure (AOR=13.5,CI=2.69-70), cavitations on chest x-ray (AOR=1.9,CI=1.1-3.38) and contact with MDR-TB patients (AOR=1.4,CI=0.19-0.39) were more likely to be MDR-TB patients. Low monthly income (AOR=1.1,CI=0.34-0.47),alcohol consumption (AOR=1.5,CI=0.2-0.98) and young age (AOR=2.9,CI=1.07-7.68) were the other risk factors of MDR-TB. Conclusions: TB treatment failure, cavitation on chest X-ray, contact with MDR-TB patients and low socioeconomic status were important risk factors for development of MDR-TB. Therefore, strict adherence to directly observed therapy, appropriate management of TB patients and advice on the value of nutrients are helpful to control the spreading of MDR-TB.

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Risk factors for multidrug resistance among previously treated patients with tuberculosis in eastern China: a case–control study

Cited by 39 publications

References 15 publications

Epidemiology of drug-resistant tuberculosis in Chongqing, China: a retrospective observational study from 2010 to 2017

Epidemiology of drug-resistant tuberculosis in Chongqing, China: a retrospective observational study from 2010 to 2017

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State.

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