Risk factors for musculoskeletal disorders among farm owners and farm workers: A systematic review

Osborne, Aoife; Blake, Catherine; Fullen, Brona M.; Meredith, David; Phelan, James; McNamara, John; Cunningham, Caitríona

doi:10.1002/ajim.22001

Cited by 70 publications

(55 citation statements)

References 46 publications

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“…The main hazards which accompany work performed on farms include: biological agents (infectious microorganisms, parasites as well as sensitizing), chemical agents (plant protection products and fertilizers) and threats connected with the effect of various physical factors [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Occupational diseases among farmers in Poland

Szeszenia-Da̧browska¹,

Świątkowska²,

Wilczyńska³

2016

Med Pr

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Background: The study's objective is to present epidemiological situation concerning the incidence of occupational diseases among farmers in Poland. Material and Methods: All 3438 cases of occupational diseases diagnosed among farmers and obligatorily reported to the Central Register of Occupational Diseases (covering all the national territory and all the cases of occupational diseases diagnosed in Poland after 1970) over the years 2000-2014 were subjected to analysis. Results: The annual incidence in the analyzed period ranged 5-14 per 100 000 farmers. The analysis showed that about 90% of pathologies were induced by the biological agents. Almost every third pathology due to biological agents had allergic origin. Infectious and parasitic diseases accounted for 62% of the cases. Among them the diseases carried by ticks (93%) -borreliosis (85.8%) and tick-borne encephalitis (7.2%) were the most frequent ones. The age of farmers, in the case of whom bronchial asthma and allergic rhinitis were diagnosed, was significantly higher than the age of remaining employees of the national economy, in which these occupational diseases were recognized. Conclusions:The study indicates the necessity to introduce periodic health examinations programs focusing on agricultural workers to monitor health and well-being and improve working conditions and the working environment. Med Pr 2016;67(2):163-171

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Section: Introductionmentioning

confidence: 99%

Occupational diseases among farmers in Poland

Szeszenia-Da̧browska¹,

Świątkowska²,

Wilczyńska³

2016

Med Pr

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“…Agricultural environmental exposure has been recognized as an independent risk factor for asthma symptoms, chronic bronchitis, and COPD development in humans (7). Farming is also a known occupational hazard for developing musculoskeletal diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA) (8)(9)(10)(11)(12). The organic dust exposure is complex, involving a wide diversity of microbial motifs (e.g., peptidoglycans [PGNs] and endotoxin) and particulate matter, which elicit airway inflammatory responses in mice (7,13).…”

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confidence: 99%

Organic Dust, Lipopolysaccharide, and Peptidoglycan Inhalant Exposures Result in Bone Loss/Disease

Dusad

Thiele

Klassen

et al. 2013

Am J Respir Cell Mol Biol

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4Veterans Administration Nebraska Western Iowa Healthcare System, Omaha, NebraskaSkeletal health consequences associated with chronic inflammatory respiratory disease, and particularly chronic obstructive pulmonary disease (COPD), contribute to overall disease morbidity. Agricultural environmental exposures induce significant airway diseases, including COPD. However, animal models to understand inhalant exposureinduced lung injury and bone disease have not been described. Using micro-computed tomography (micro-CT) imaging technology and histology, bone quantity and quality measurements were investigated in mice after repetitive intranasal inhalation exposures to complex organic dust extracts (ODEs) from swine confinement facilities. Comparison experiments with LPS and peptidoglycan (PGN) alone were also performed. After 3 weeks of repetitive ODE inhalation exposure, significant loss of bone mineral density and trabecular bone volume fraction was evident, with altered morphological microarchitecture changes in the trabecular bone, compared with saline-treated control animals. Torsional resistance was also significantly reduced. Compared with saline treatment, ODE-treated mice demonstrated decreased collagen and proteoglycan content in their articular cartilage, according to histopathology. Significant bone deterioration was also evident after repetitive intranasal inhalant treatment with LPS and PGN. These findings were not secondary to animal distress, and not entirely dependent on the degree of induced lung parenchymal inflammation. Repetitive LPS treatment demonstrated the most pronounced changes in bone parameters, and PGN treatment resulted in the greatest lung parenchymal inflammatory changes. Collectively, repetitive inhalation exposures to noninfectious inflammatory agents such as complex organic dust, LPS, and PGN resulted in bone loss. This animal model may contribute to efforts toward understanding the mechanisms and evaluating the therapeutics associated with adverse skeletal health consequences after subchronic airway injury.

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“…Because clinical approaches exist for blocking IL-6 [45,46], future studies could investigate the role of IL-6 in modulating bone deterioration induced by chronic airway inflammatory agents. Our studies are focused on the lungbone axis because of the high prevalence of bone and airway disease in agricultural workers [9][10][11]. However, these data might have broader implications for understanding adverse systemic manifestations (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately two-thirds of agriculture workers develop respiratory diseases (e.g. rhinosinusitis, asthma, chronic bronchitis, COPD) [6][7][8][9], and nearly 90% suffer from musculoskeletal disease, including high fracture rates [10][11][12]. Recently, we established an animal model demonstrating that intranasal inhalation of organic dust extract (ODE) collected from large animal (swine) confinement facilities and its microbial components induce systemic bone loss [13].…”

Section: Introductionmentioning

confidence: 99%

Toll-like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss

Poole

Klein

Dusad

et al. 2016

Journal of Allergy and Clinical Immunology

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Agriculture workers have increased rates of airway and skeletal disease. Inhalant exposure to agricultural organic dust extract (ODE) induces bone deterioration in mice; yet, mechanisms underlying lung-bone crosstalk remain unclear. Because Toll-like receptor 2 (TLR2) and TLR4 are important in mediating the airway consequences of ODE, this study investigated their role in regulating bone responses. First, swine facility ODE stimulated wild-type (WT) bone marrow macrophages to form osteoclasts, and this finding was inhibited in TLR4 knock-out (KO), but not TLR2 KO cells. Next, using an established intranasal inhalation exposure model, WT, TLR2 KO and TLR4 KO mice were treated daily with ODE or saline for 3 weeks. ODE-induced airway neutrophil influx and cytokine/chemokine release were similarly reduced in TLR2 and TLR4 KO animals as compared to WT mice. Utilizing micro-computed tomography (CT), analysis of tibia showed loss of bone mineral density, volume and deterioration of bone micro-architecture and mechanical strength induced by ODE in WT mice were significantly reduced in TLR4 but not TLR2 KO animals. Bone marrow osteoclast precursor cell populations were analyzed by flow cytometry from exposed animals. In WT animals, exposure to inhalant ODE increased osteoclast precursor cell populations as compared to saline, an effect that was reduced in TLR4 but not TLR2 KO mice. These results show that TLR2 and TLR4 pathways mediate ODE-induced airway inflammation, but bone deterioration consequences following inhalant ODE treatment is strongly dependent upon TLR4. Thus, the TLR4 signaling pathway appears critical in regulating the lung-bone inflammatory axis to microbial component-enriched organic dust exposures.

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Risk factors for musculoskeletal disorders among farm owners and farm workers: A systematic review

Cited by 70 publications

References 46 publications

Occupational diseases among farmers in Poland

Occupational diseases among farmers in Poland

Organic Dust, Lipopolysaccharide, and Peptidoglycan Inhalant Exposures Result in Bone Loss/Disease

Toll-like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss

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