Risk factors for need of mechanical ventilation in children with Influenza A(H1N1)pdm09

Abstract

The presence of chronic diseases as predictors reinforces previous finding. Furthermore, viral co-detection was found to be a risk factor. Further studies are necessary to confirm this association.

Evaluation of nasal levels of interferon and clinical severity of influenza in children

“…Clinical characteristics of the influenza virus are difficult to distinguish from those of other respiratory viruses [6][7][8][9][10][11]. Risk factors for the severe clinical course are comorbidities and young age, but complications may occur in children without these conditions [12][13][14][15][16][17]. Additionally, antiviral treatments modestly affect the clinical course [18,19].…”

Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis

“…The relationship between detection of multiple respiratory viral infections and severity of disease in children has not been well established. Several studies have reported longer length of stay in hospital, an increased risk of hospitalizations, of admission to pediatric intensive care unit (PICU), of need for mechanical ventilation and even higher mortality, when two or more respiratory viruses were detected [11][12][13][14][15][16][17].…”

Respiratory viral coinfection and clinical disease severity

“…In this issue of the Jornal de Pediatria, Scotta et al 1 report on a retrospective study of 120 Brazilian children hospitalized with pH1N1 infection, which found respiratory viral coinfection to be a risk factor for respiratory failure. Consistent with this finding, Torres et al observed that viral coinfection with respiratory syncytial virus (RSV) was associated with increased mortality in a multivariable analysis of 142 children admitted for intensive care during the first pandemic wave in Argentina.…”