2016
DOI: 10.1186/s13613-016-0205-x
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Risk factors for new-onset delirium in patients with bloodstream infections: independent and quantitative effect of catheters and drainages—a four-year cohort study

Abstract: BackgroundBloodstream infections (BSI) and delirium are frequent in critically ill patients. During systemic inflammatory response to BSI, cytokines may interact with neurotransmitters and neuronal receptors driving acute brain dysfunction. However, prospectively collected data on incidence, prediction and impact of delirium in association with BSI are lacking. This study aimed to determine the incidence and predictors of new-onset delirium and its impact on outcome in critically ill adult patients with BSI.Me… Show more

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Cited by 18 publications
(20 citation statements)
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“…Participants in the ICDSC-delirium group had a 4.93-fold higher mortality risk and stayed at the hospital 17.59 days longer than those in the no-delirium group, while those in the CAM-ICU group were linked with a 2.79-fold lower odds of mortality. This nding is consistent with prior reports that ICU delirium increased hospital mortality in patients evaluated by either the ICDSC [23][24][25] or CAM-ICU [5,6,[27][28], but different from a previous nding that the CAM-ICU better predicted outcome [22]. The reason for this difference requires further study, but one factor to consider is participants' arousal state.…”
Section: Discussionsupporting
confidence: 86%
“…Participants in the ICDSC-delirium group had a 4.93-fold higher mortality risk and stayed at the hospital 17.59 days longer than those in the no-delirium group, while those in the CAM-ICU group were linked with a 2.79-fold lower odds of mortality. This nding is consistent with prior reports that ICU delirium increased hospital mortality in patients evaluated by either the ICDSC [23][24][25] or CAM-ICU [5,6,[27][28], but different from a previous nding that the CAM-ICU better predicted outcome [22]. The reason for this difference requires further study, but one factor to consider is participants' arousal state.…”
Section: Discussionsupporting
confidence: 86%
“…Moreover, in our population male sex was associated with delirium. Contrasting results are reported in literature, concerning gender as a risk factor for delirium, but evidence referring to different clinical settings suggests that men have a significantly higher chance of developing delirium [41][42][43]. Referring to fracture patients, greater levels of cognitive impairment within the first days of hip fracture have been reported in male patients [44].…”
Section: Discussionmentioning
confidence: 68%
“…34,38,39 Delirium has also been associated with an increased likelihood of being discharged to a long-term care facility, and patients with blood stream infections were also less likely to return to their baseline functional status. 34,40 Brummel and colleagues demonstrated that critically ill patients on mechanical ventilation who develop delirium had substantial impairments in their basic activities of daily living as well as worse sensory-motor function at 3 and 12 month follow-up. 41 Prolonged mechanical ventilation and disability secondary to delirium prevents patients from returning to their baseline and reduces their overall quality of life.…”
Section: Discussionmentioning
confidence: 99%