Risk factors for new-onset diabetes mellitus after kidney transplantation (NODAT): a Brazilian single center study

Abstract

Objectives: This study aims to verify the new-onset diabetes after kidney transplant (NODAT) incidence in recipients within 1 year after kidney transplantation from a single center in Southern Brazil and to assess the associated conditions. Subjects and methods: A retrospective study of 258 postrenal transplant patients was performed. Demographic (gender, age, ethnic background) and clinical (origin of graft, associated infections, body mass index (BMI) at transplant time and 6 and 12 months after, causes of renal failure, and comorbidities) data were analyzed. All patients were on tacrolimus, mycophenolate mofetil, and prednisone treatment. Patients with and without NODAT were compared. Results: A NODAT incidence of 31.2% was noted 1 year post transplantation. In the univariate analysis, patients with NODAT were older (p = 0.001), mostly had African-American ethnic background (p = 0.02), and had renal failure secondary to high blood pressure (HBP) (p = 0.001). The group of patients with NODAT also had more incidence of post-transplant HBP (p = 0.01), heart failure (p = 0.02), and dyslipidemia (p = 0.001). Logistic regression showed that African-American ethnic background, posttransplant HBP, and dyslipidemia were independently associated with NODAT. Conclusion: This study shows a NODAT incidence that is greater in patients with African-American ethnic background and that is associated with HBP and dyslipidemia.

Clinical and genetic risk factors for new-onset diabetes mellitus after transplantation (NODAT) in major transplant centres in Malaysia

“…Polymorphisms in the IL7R (rs1494558) and MBL2 (rs2232365) genes were associated with a higher risk of NODAT among pooled Malaysian renal transplanted populations. Despite similar diagnostic criteria, high variability in the incidence of NODAT within 1 year posttransplantation has been reported in different populations [19][20][21]. The incidence of NODAT at one-year post-transplantation in our study was slightly higher [14] in their studies in single centres in Malaysia.…”

Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience

“…Lima et al reported it in their cohort study carried out in Brazil with 209 patients of whom 53 were afro-descendants. This characteristic showed a significant difference in its distribution between the group with NODAT and without the disease (30.2% vs 17.5%, p = 0.02), as it was seen in our study [ 17 ].…”

“…is characteristic showed a significant difference in its distribution between the group with NODAT and without the disease (30.2% vs 17.5%, p � 0.02), as it was seen in our study [17].…”

“…The association with afro-descendant ethnicity has also been described in other studies [ 16 , 17 ]. Lima et al reported it in their cohort study carried out in Brazil with 209 patients of whom 53 were afro-descendants.…”

Risk factors for new‐onset diabetes mellitus after kidney transplantation: A systematic review and meta‐analysis

“…New-onset diabetes mellitus after transplantation (NODAT) refers to the detection of diabetes after a successful organ transplantation in patients who had not previously shown abnormal blood glucose levels before surgery. With the continuous developments and improvements in the field of organ transplantation, kidney transplantation has been carried out in an increasing number of patients; however, NODAT often occurs after kidney transplantation, with an incidence rate of 2-50% [1][2][3] . NODAT can lead to related complications, such as kidney transplant failure, cardiovascular disease and infection 4 , seriously endangering the quality of life and prognosis of patients with a kidney transplant, and increasing their economic burden.…”