Risk factors for operated carpal tunnel syndrome: a multicenter population-based case-control study

Abstract

Background: Carpal tunnel syndrome (CTS) is a socially and economically relevant disease caused by compression or entrapment of the median nerve within the carpal tunnel. This population-based case-control study aims to investigate occupational/non-occupational risk factors for surgically treated CTS.

Validation of the ACGIH TLV for hand activity level in the OCTOPUS cohort: a two-year longitudinal study of carpal tunnel syndrome

“…In our longitudinal study, the occupational biomechanical exposure of the hand-wrist system was carefully assessed according to the ACGIH recommendations, and we found an important increase in risk of CTS for women. Age is a well-known predictor of the disease (4, 5, 33), alongside BMI (7,8,34).…”

“…Widely cited personal factors of CTS include gender, body mass index (BMI), height, marital status, familiar history, and other pathologies facilitating CTS onset (eg, rheumatoid arthritis, diabetes) (7,8). There are a number of epidemiological studies that show a relationship between manual work (especially repetitive and forceful exertions) and CTS (9)(10)(11); however, many of these studies are cross-sectional and a causal relationship cannot therefore be concluded (9).…”

Carpal tunnel syndrome and manual work: the OCTOPUS cohort, results of a ten-year longitudinal study

“…Thus, CTS is a common cause of work disability and determines high healthcare expenditures (6,7). A large amount of literature documented that CTS is associated with several personal characteristics, including increasing age, overweight/obesity, female gender, and musculoskeletal comorbidities (eg, trigger finger, rotator cuff syndrome, and cervical radiculopathy -double crush syndrome) (8)(9)(10)(11)(12). Many clinical investigations have focused on the role of systemic diseases in increasing the risk of CTS.…”

Ultrasound evaluation on carpal tunnel syndrome before and after bariatric surgery

“…It can therefore be concluded that obesity is associated with CTS, but weight loss in bariatric surgery is not sufficient to improve its repercussions in daily life. The higher prevalence of CTS in obese individuals is already well known in the literature [6][7][8][9][10][11][12][13] . Similarly, Moghtaderi et al 8 conducted a case-control study examining risk factors for CTS and demonstrated that BMI, age and anthropometric data of the wrist were higher in patients with CTS than in controls.…”

“…The most widely accepted theories for CTS ethiopathology are the mechanical and the microvascular nerve damage 2 . Many authors considered obesity as a predisposing factor [6][7][8][9][10][11][12][13] , as it may be associated to the mechanical theory when the fat tissue causes nerve root compression and raises local hydrostatic pressure 10,12 . However, microvascular insufficiency secondary to atherosclerosis, which is more common in the obese population 13 , may also play a role.…”