Risk factors for osteoporosis and fractures in rheumatoid arthritis

Baker, Rahaf; Narla, Radhika; Baker, Joshua F.; Wysham, Katherine D

doi:10.1016/j.berh.2022.101773

Cited by 21 publications

(11 citation statements)

References 81 publications

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“…Similarly, osteoporosis risk could be causally increased by the presence of anti-citrullinated peptide antibodies (ACPA) in Asians [ 72 , 73 ]. The presence of ACPA, a prolonged RA disease duration, significant exposure to corticosteroids, decreased physical activity, or a history of low trauma fractures are the risk factors of OP or fragility fractures in RA [ 73 , 74 ].…”

Section: Etiopathogenesis Of Ra and Its Comorbiditiesmentioning

confidence: 99%

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review

Chen,

Tang,

Chen

2024

IJMS

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Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by chronic synovitis and the progressive destruction of cartilage and bone. RA is commonly accompanied by extra-articular comorbidities. The pathogenesis of RA and its comorbidities is complex and not completely elucidated. The assembly of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activates caspase-1, which induces the maturation of interleukin (IL)-1β and IL-18 and leads to the cleavage of gasdermin D with promoting pyroptosis. Accumulative evidence indicates the pathogenic role of NLRP3 inflammasome signaling in RA and its comorbidities, including atherosclerotic cardiovascular disease, osteoporosis, and interstitial lung diseases. Although the available therapeutic agents are effective for RA treatment, their high cost and increased infection rate are causes for concern. Recent evidence revealed the components of the NLRP3 inflammasome as potential therapeutic targets in RA and its comorbidities. In this review, we searched the MEDLINE database using the PubMed interface and reviewed English-language literature on the NLRP3 inflammasome in RA and its comorbidities from 2000 to 2023. The current evidence reveals that the NLRP3 inflammasome contributes to the pathogenesis of RA and its comorbidities. Consequently, the components of the NLRP3 inflammasome signaling pathway represent promising therapeutic targets, and ongoing research might lead to the development of new, effective treatments for RA and its comorbidities.

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Section: Etiopathogenesis Of Ra and Its Comorbiditiesmentioning

confidence: 99%

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review

Chen,

Tang,

Chen

2024

IJMS

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“…During the course of RA, inflammatory factors induce osteoclast differentiation but inhibit osteoblast maturation. The aggravation of bone loss caused by this imbalance in bone metabolism is the main reason for RA complicated with OP ( 98 , 99 ). Moreover, the long-term clinical use of mainstream drugs such as glucocorticoids and immunosuppressants can also induce the development of OP.…”

Section: Potential Role Of Ferroptosis In Ra Inflammation and Tissue ...mentioning

confidence: 99%

Ferroptosis as an emerging target in rheumatoid arthritis

Zhao,

Tang,

Wang

et al. 2023

Front. Immunol.

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Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. Due to the rise in the incidence rate of RA and the limitations of existing therapies, the search for new treatment strategies for RA has become a global focus. Ferroptosis is a novel programmed cell death characterized by iron-dependent lipid peroxidation, with distinct differences from apoptosis, autophagy, and necrosis. Under the conditions of iron accumulation and the glutathione peroxidase 4 (GPX4) activity loss, the lethal accumulation of lipid peroxide is the direct cause of ferroptosis. Ferroptosis mediates inflammation, oxidative stress, and lipid oxidative damage processes, and also participates in the occurrence and pathological progression of inflammatory joint diseases including RA. This review provides insight into the role and mechanism of ferroptosis in RA and discusses the potential and challenges of ferroptosis as a new therapeutic strategy for RA, with an effort to provide new targets for RA prevention and treatment.

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“…Osteoporosis is a significant comorbidity of RA because systemic inflammation can have harmful effects on bone health 2 . Various factors can worsen osteoporosis, including age, postmenopausal status, glucocorticoid use, sarcopenia, low body mass index, presence of anti‐citrullinated protein/peptide antibodies, vitamin D deficiency, and smoking 3 . RA carries a fracture risk above that provided by bone mineral density (BMD) and is considered an independent risk factor of fracture according to The World Health Organization Fracture Risk Assessment tool (FRAX) 4 .…”

Section: Introductionmentioning

confidence: 99%

Low Hounsfield unit values on computed tomography as a potential predictor of vertebral fracture in patients with rheumatoid arthritis: The KURAMA cohort study

Umeda,

Murata,

Murotani

et al. 2024

Int J of Rheum Dis

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ObjectiveHounsfield units (HU) measured using computed tomography (CT) have gained considerable attention for the detection of osteoporosis. This study aimed to investigate whether opportunistic CT could predict vertebral fractures in patients with rheumatoid arthritis (RA).MethodsA total of 233 patients with RA who underwent chest CT were included in this study. The HU values of the anterior 1/3 of the vertebral bodies based on the sagittal plane at T11–L2 after reconstruction were measured. The incidence of vertebral fractures was investigated with respect to the HU value.ResultsVertebral fractures were identified in 32 patients during a mean follow‐up period of 3.8 years. In patients who experienced vertebral fractures within 2 years of CT imaging, the HU values of the vertebral bodies (T11–L2) were lower than those in patients who did not experience fractures. Receiver operating characteristic curve analysis identified that a T11 HU value of <125 was a risk factor for vertebral fracture within 2 years. Multivariate analysis showed that a T11 HU value of <125 and the existence of prevalent vertebral fractures were significant risk factors for fracture.ConclusionHU measurements of the anterior 1/3 of the vertebral body are a potential predictor for vertebral fractures in patients with RA.

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Risk factors for osteoporosis and fractures in rheumatoid arthritis

Cited by 21 publications

References 81 publications

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review

Ferroptosis as an emerging target in rheumatoid arthritis

Low Hounsfield unit values on computed tomography as a potential predictor of vertebral fracture in patients with rheumatoid arthritis: The KURAMA cohort study

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