Risk Factors for Pancreatic Cancer: Emerging Role of Viral Hepatitis

Gheorghe, Gina; Diaconu, Camelia Cristina; Ionescu, Vlad; Constantinescu, Gabriel; Bacalbaşa, Nicolae; Bungău, Simona; Găman, Mihnea‐Alexandru; Stan-Ilie, Mădălina

doi:10.3390/jpm12010083

Cited by 17 publications

(13 citation statements)

References 93 publications

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“…cancer is one of the worst prognosis malignant tumors, with a bad 5 years survival rate which is not more than 10% in the USA 10 .…”

Section: Discussionmentioning

confidence: 99%

“…**SMA: Superior Mesenteric Artery, SMV: Superior Mesenteric Vein, PV: Portal Vein, HA: Hepatic Artery, CA: Celiac Artery, SPV: splenic Vein, SPA: Splenic Artery. **This table showed vascular evaluation of pancreatic cancer and there was no signi cant difference between CT and EUS as regard vascular evaluation Regarding diagnostic accuracy of EUS in venous invasion table(9) showed the corrected (after correction of veins by considering every vein as a separate case) diagnostic ability of EUS for evaluation of venous invasion in pancreatic cancer with a sensitivity of 100%, a speci city of 95.93%, positive predictive value of 84.38%, negative predictive value 100% and Accuracy 96% compared to CT the gold standard for vascular evaluation in cancer pancreas.Regarding diagnostic accuracy of EUS in arterial invasion table(10) showed the corrected (after correction of arteries by considering every artery as a separate case) diagnostic ability of EUS for evaluation of arterial invasion in pancreatic cancer with a sensitivity of 95.65%, speci city of 100%, positive predictive value of 100%, negative predictive value 99.44% and Accuracy 99.5% compared to CT the gold standard for vascular evaluation in cancer pancreas.…”

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confidence: 99%

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Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

El-Nady

Hassan

Haridy

et al. 2023

Preprint

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Background: computed tomography (CT) of the abdomen with contrast is the gold standard method for the evaluation of pancreatic cancer concerning staging and vascular assessment. however, not all patients can be evaluated by contrast-enhanced CT abdomen as those with an allergy to the contrast agent, pregnancy, and renal impairment, in addition to hazards of radiation and non-availability of tissue sampling in CECT abdomen .so this study was designed to evaluate the diagnostic ability of Endoscopic Ultrasound for staging and vascular assessment of pancreatic cancer in comparison to CT abdomen with contrast. Method: fifty patients with cancer pancreas were evaluated by CECT and EUS as regard staging and vascular invasion. The vascular assessment was done by dividing the EUS findings into three types by the relationship between tumors and major vessels, type 1, clear invasion, encasement of the vessel by a tumor or tumor that contacts a vessel wall more than 180o; type2, Abutment, a tumor that contacts a vessel wall but less than 180o and type 3, clear non-invasion, the existence of distance between a tumor and a vessel. We regarded type 1 and type 2 as signs of vascular invasion and type 3 as a sign of vascular non-invasion, these findings were compared with the findings of the CECT abdomen. The endoscopist was blind to the CT result before the EUS examination. Result: as regards staging of pancreatic cancer EUS showed sensitivity, specificity, and accuracy of 100% for all. and as regard vascular invasion EUS showed sensitivity, specificity, and accuracy of 100%,95.93%, and 96% respectively for venous invasion and 95.65%,100%, and 99.5% for arterial invasion. Conclusion: EUS can evaluate staging and vascular invasion of pancreatic cancer with very high sensitivity, specificity, and accuracy to the extent it can replace CT in evaluation, with the superiority of EUS due to tissue sampling.

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“…cancer is one of the worst prognosis malignant tumors, with a bad 5 years survival rate which is not more than 10% in the USA 10 .…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

El-Nady

Hassan

Haridy

et al. 2023

Preprint

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show abstract

“…Pancreatic cancer is one of the most aggressive malignant tumors, with a 5-year survival rate of about 10% in the United States of America (USA) 9 .…”

Section: Discussionmentioning

confidence: 99%

Role of endoscopic ultrasound in primary staging and vascular assessment of pancreatic cancer

El-Nady

Haridy

Hassan

et al. 2022

Preprint

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Background: computed tomography (CT) of the abdomen with contrast is the gold standard method for primary evaluation of pancreatic cancer as regard to staging and vascular assessment. however, not all patients can be evaluated by contrast enhanced CT abdomen as those with allergy to the contrast agent, pregnancy, renal impairment, in addition to hazards of radiation and non-availability of tissue sampling in CECT abdomen .so this study was designed to evaluate the diagnostic ability of Endoscopic Ultrasound for staging and vascular assessment of pancreatic cancer in comparison to CT abdomen with contrast. Method: fifty patients with cancer pancreas were evaluated by EUS as regard staging and vascular invasion. Vascular assessment was done by dividing the EUS findings into three types in accordance with the relationship between tumors and major vessels, type 1, clear invasion, encasement of vessel by a tumor or tumor that contact a vessel wall more than 180o; type2, Abutment, a tumor that contacts a vessel wall but less than 180o and type 3, clear non-invasion, existence of distance between a tumor and a vessel. We regarded types 1 and type 2 as signs of vascular invasion and types 3 as sign of vascular non-invasion, these findings were compared with the findings of CT abdomen with contrast. The endoscopist was blind to CT result before EUS examination. Result: as regard to staging of pancreatic cancer EUS showed sensitivity, specificity and accuracy of 100% for all. and as regard vascular invasion EUS showed sensitivity, specificity and accuracy of 100% ,95.93% and 96% respectively for venous invasion and 95.65% ,100% and 99.5% for arterial invasion. Conclusion: EUS can evaluate staging and vascular invasion of pancreatic cancer with very high sensitivity, specificity and accuracy to the extend it can replace CT in primary evaluation, with superiority of EUS due to tissue sampling.

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“…Similarly, HBV antigens and replicative sequences have been identified in extrahepatic organs, including the pancreas (6). For this reason, some scholars speculated that the existence of HBV in pancreatic tissue could cause chronic pancreatic inflammation such as that in hepatic tissues, with the possibility of progression to malignant transformation (77). Contrastingly, HBV infection patients with pancreatic carcinoma demonstrated different metastatic patterns and survival (44), where HBV infection increased the synchronous liver metastasis rate in the patients.…”

Section: Pancreatic Carcinomamentioning

confidence: 99%

“…Unlike HPV-induced esophageal cancer, there remains a lack of robust evidence to explain the association between HBV infection and esophageal cancer. The histological examination of HBV-related indicators from esophageal epithelial cells might aid the exploration of detailed associations such as that in other gastrointestinal sites (52,59,77).…”

Section: Esophageal Cancermentioning

confidence: 99%

Hepatitis B virus infection: An insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk

Wei

Xia³

et al. 2023

Front. Immunol.

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The evidence for chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) occurrence is well established. The hepatocyte epithelium carcinogenesis caused by HBV has been investigated and reviewed in depth. Nevertheless, recent findings from preclinical and observational studies suggested that chronic HBV infection is equally important in extrahepatic cancer occurrence and survival, specifically gastrointestinal system-derived cancers. Immune microenvironment changes (immune-suppressive cytokine infiltration), epigenetic modification (N6-methyladenosine), molecular signaling pathways (PI3K–Akt and Wnt), and serum biomarkers such as hepatitis B virus X (HBx) protein are potential underlying mechanisms in chronic HBV infection-induced extrahepatic cancers. This narrative review aimed to comprehensively summarize the most recent advances in evaluating the association between chronic HBV infection and extrahepatic cancer risk and explore the potential underlying molecular mechanisms in the carcinogenesis induction of extrahepatic cancers in chronic HBV conditions.

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Risk Factors for Pancreatic Cancer: Emerging Role of Viral Hepatitis

Cited by 17 publications

References 93 publications

Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

Role of endoscopic ultrasound in primary staging and vascular assessment of pancreatic cancer

Hepatitis B virus infection: An insight into the clinical connection and molecular interaction between hepatitis B virus and host extrahepatic cancer risk

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