AimThis systematic review investigates the effectiveness of implant therapy in patients with and without a history of periodontitis in terms of implant loss, peri‐implant marginal bone loss (MBL), and occurrence of peri‐implant diseases.MethodsThe protocol of the present meta‐analysis was registered on PROSPERO (CRD42021264980). An electronic search was conducted up to April 2024. All prospective cohort studies reporting implant loss, MBL, and occurrence of peri‐implant diseases in both patients with a history of periodontitis (HP) and patients with no history of periodontitis (NHP) after at least 36‐month follow‐up were included. The risk of bias was evaluated using the Newcastle‐Ottawa Scale and the quality of the evidence was also assessed. A meta‐analysis was performed on the selected outcomes at the available follow‐up time points. Subgroup analyses were conducted based on follow‐up time, rate of progression and severity of periodontitis, and implant surface characteristics. Publication bias was evaluated using the Funnel plot and Egger's test.ResultsFrom 13 761 initial records, 14 studies (17 articles) were finally included. Eight studies had a low risk of bias level, and six had a medium risk of bias level. Meta‐analysis showed that HP patients had a significantly greater risk for implant loss (HR: 1.75; 95% CI: 1.28–2.40; p = 0.0005; I2 = 0%), MBL (MD: 0.41 mm; 95% CI 0.19, 0.63; p = 0.0002; I2 = 54%), and peri‐implantitis (3.24; 95% CI: 1.58–6.64; p = 0.001; I2 = 57%) compared to NHP, whereas no significant intergroup difference for peri‐implant mucositis was found. Subgroup analyses revealed a particularly greater risk for implant loss for HP patients over a ≥ 10‐year follow‐up (HR: 2.02; 95% CI: 1.06–3.85; p = 0.03; I2 = 0%) and for patients with a history of grade C (formerly aggressive) periodontitis (HR: 6.16; 95% CI: 2.53–15.01; p < 0.0001; I2 = 0%). A greater risk for implant loss for stages III–IV (severe) periodontitis, and implants with rough surfaces was also found.ConclusionsWithin the limits of heterogeneous case definitions and methods of assessment, a history of periodontitis has been proved to significantly increase the risk for implant loss, particularly at long follow‐up (≥ 10 years) and in case of rapidly progressive forms (grade C), and for MBL and peri‐implantitis.
