Risk Factors for Poor Health-related Quality of Life in Patients With Colon Cancer Include Stoma and Smoking Habits

Abstract

Objectives: Studies have shown that poor Health-related quality of life (HRQoL) might worsen the cancer-related prognosis. The aim of this study was to investigate risk factors for poor HRQoL in patients with colon cancer.Method: This was a prospective population-based study of patients with colon cancer included between 2012 and 2016. HRQoL was measured using the cancer-specific European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. Multiple linear regression analysis adjusted for age, sex, body mass index, smoking habits, American Society of Anesthesiologists physical status classification, emergency/elective surgery, resection with/without a stoma and tumour stage was used.Results: A total of 67% (376/561) of all incident patients with colon cancer (196 [52.1%] females) was included. Mean (range) age was 73 (30–96) years. Patients with more comorbidity (American Society of Anesthesiologists status 3 and 4), those with higher body mass index, smokers and patients who were planned to be operated on with a stoma were at a higher risk for poor QoL than the other included patients at baseline and at 6 months of follow-up.Conclusion: These findings may be used to provide more individualized attention to patients who need more support from health care.ClinicalTrials.gov (NCT 03910894)

A new stoma for an older person—An association with quality of life and physical function: A systematic review

“…No randomized controlled studies were identified. The studies originated from Spain, 32 Germany, 20,24,27,33 USA, 22,28,29,34–36 China, 37,38 Italy, 21 Sweden, 23,39 the United Kingdom, 25,26,40 the Netherlands, 31,41,42 New Zealand, 30 Denmark, 43 and Canada 44 . In total 6972 participants were included.…”

“…Twenty‐four (96%) of the studies had good selection, and 12 studies (48%) were assessed as having good comparability using the Newcastle‐Ottawa Scale assessment tool (Table S5). Thirteen of the twenty‐five studies (52%) exhibited a study level “good” quality assessment, 21–23,27–30,32,33,37,41–43 eight (32%) “fair” quality, 20,25,31,35,38–40,44 and four (20%) “unclear” quality, 24,26,34,36 and none of the included studies were found to be of “poor” quality.…”

“…Physical function was reported in nine studies: four of the studies used a domain of the Short Form 36 Health Survey Questionnaire (SF‐36) quality of life score 25,28,29,31 ; four used a domain of the European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ‐C30), 21,23,24,27 an internationally validated and widely used cancer‐specific quality of life questionnaire with a domain dedicated to assessing physical function; one study calculated physical function using the “systemic symptoms” domain of the Burwood quality of life questionnaire—a subjective measure of quality of life related to bowel function following spinal cord injury 30 …”

“…Twelve studies addressed the secondary outcome of quality of life, 20–31 which included 4460 participants. Seven of these found a positive association between the presence of stoma and worse quality of life 22–26,28,29 .…”

“…Twelve studies addressed the secondary outcome of quality of life, 20–31 which included 4460 participants. Seven of these found a positive association between the presence of stoma and worse quality of life 22–26,28,29 . Two of these studies did not provide overall scores but reported that participants with a stoma scored lower in five out of the eight quality‐of‐life domains 25,29 .…”