2020
DOI: 10.1097/icu.0000000000000662
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Risk factors for postlaser refractive surgery corneal ectasia

Abstract: Purpose of review To summarize newly reported and update previously known risk factors for post laser vision correction (LVC) corneal ectasia. Recent findings Advances in corneal topography and tomography have improved detection of preclinical ectasia-related changes. This has allowed for enhanced screening of surgical candidates. There are also known genetic predispositions for corneal ectasia, and recent genetic analyses have revealed various genes an… Show more

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Cited by 32 publications
(26 citation statements)
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“…The physiology of this initial thinning and subsequent rethickening is not entirely clear; however, epithelial remodeling is likely an early factor in corneal thickness changes. Furthermore, anatomic and structural changes of corneal collagen fibrils, such as compression of collagen fibrils, 10 , 23 changes in corneal hydration 24 and edema, 25 , 26 keratocyte apoptosis, 13 , 27 , 28 changes in glycosaminoglycans, 29 and other processes, might be implicated in the distinct clinical time course after CXL.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The physiology of this initial thinning and subsequent rethickening is not entirely clear; however, epithelial remodeling is likely an early factor in corneal thickness changes. Furthermore, anatomic and structural changes of corneal collagen fibrils, such as compression of collagen fibrils, 10 , 23 changes in corneal hydration 24 and edema, 25 , 26 keratocyte apoptosis, 13 , 27 , 28 changes in glycosaminoglycans, 29 and other processes, might be implicated in the distinct clinical time course after CXL.…”
Section: Discussionmentioning
confidence: 99%
“…Specific risk factors for ectasia include preoperative high myopia, thin residual stromal bed, total percentage of tissue altered by both the flap thickness and tissue removed, forme fruste keratoconus, and irregular preoperative topography. 8 10 …”
Section: Introductionmentioning
confidence: 99%
“…However, iatrogenic keratectasia has emerged as a serious complication of laser vision correction surgery [ 2 ]. Owning to advancements in diagnosis and femtosecond laser platforms, the incidence of iatrogenic keratectasia has decreased from 0.66 to 0.021% [ 3 , 4 ]. Risk is associated with the amount of tissue altered and therefore, high myopia, unevenly distributed corneal thickness, abnormal corneal topography, hyperopic treatments, weakened corneal biomechanical properties, and thin predicted residual corneal thickness are risk factors [ 2 , 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…The possibility of postoperative ectasia following corneal laser refractive surgery (CLRS) is an ongoing concern within the ophthalmic community [ 1 , 2 ]. Although uncommon, occurrences of ectasia have been observed after laser-assisted in situ keratomileusis (LASIK) and have also been reported after less disruptive procedures such as small incision lenticule extraction (SMILE) [ 3 , 4 ].…”
Section: Introductionmentioning
confidence: 99%