Risk Factors for Premenopausal Breast Cancer: A Case-control Study in Uruguay

Abstract

In order to thoroughly analyze risk factors of breast cancer (BC) in premenopausal Uruguayan women, a case-control study was carried out at the Pereira Rossell Women's Hospital, Montevideo, where 253 incident BC cases and 497 frequency-matched healthy controls were interviewed on menstrual and reproductive story, were administered a short food frequency questionnaire and undertook a series of body measurements necessary to calculate body composition and somatotype. Odds ratio (OR) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Among the classical risk factors, only the family history of BC in first degree relatives was significantly associated with risk of premenopausal BC (OR=2.20, 95% CI 1.33-3.62). Interestingly, this risk factor was found to be stronger in women of ages >40 (OR=4.05, 95% CI 2.10-7.81), late menarche (OR= 2.39, 95% CI 1.18-4.

Breast Cancer Risk Factors in Women Participating in a Breast Screening Program: a Study on 11,850 Iranian Females

“…In line with the studies by Naini et al in Mazandaran province, Iran (Naieni et al, 2007) and Yavari et al in Tehran (Yavari et al, 2004), the results of bivariate analysis showed that postmenopausal status increased the risk of breast cancer, but this effect diminished in multivariate analysis after adjusting for age, which is also in agreement with the results of other studies conducted on the issue (Ghiasvand et al, 2011). Similar to other studies (Yavari et al, 2004;Ghiasvand et al, 2011;Ghiasvand et al, 2012;Ronco et al, 2012a), the present study revealed no significant association between breastfeeding and risk of breast cancer (Yavari et al, 2004;Naieni et al, 2007;Gajalakshmi et al, 2009). Although childbearing could reduce the risk of breast cancer, the role of breastfeeding is not clear yet (do Carmo Franca-Botelho et al, 2012).…”

Lifestyle Components and Primary Breast Cancer Prevention

“…Similarly, a case-control study in Malaysia (382 breast cancer cases and 382 control group) carried out by Sulaiman et al (2011) reported a lack of association between total fat and fat subtypes intake and BC risk in premenopausal and postmenopausal women. On the other hand, Ronco et al (2012) observed an increased risk with a high consumption of red meat and fried food (OR=2.20, 95%CI=1.35-3.60 and OR=1.79, 95%CI=1.12-2.84, respectively) in premenopausal Uruguayan women. Contrary to these observation, a high intake of plant food exhibited a protective effect (OR=0.41, 95%CI=0.25-0.65).…”

Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms and Breast Cancer Risk in a Chinese Population

“…The mechanism of breast carcinogenesis is still not fully understood. Breast cancer may result from multiple environmental, dietary, hereditary, racial and socioeconomic risk factors (Ronco et al, 2012a;Ronco et al, 2012b;Zhang et al, 2012;Zhou et al, 2012a;Zhou et al, 2012b;Shamsi et al, 2013;Sun et al, 2013).…”