Risk Factors for Primary Open Angle Glaucoma (POAG) Progression: A Study Ruled in Torino

Abstract

Purpose: Aim of this retrospective, observational study is to describe features of a population sample, affected by primary open angle glaucoma (POAG) in order to evaluate damage progression on the basis of the emerged individual risk factors. Methods: We included 190 caucasian patients (377 eyes), evaluating relationship between individual risk factors (explicative variables) and MD (Mean Deviation) of standard automated perimetry. We also considered the dependent variable NFI (Neural Fiber Index) of GDx scanning laser polarimetry. Progression has been evaluated through a statistic General Linear Model on four follow up steps (mean follow up 79 months). Results: Factors reaching statistical significance, determining a worsening of the MD variable, are: age (P<0.0001), intraocular pressure (IOP) at follow up (P < 0.0001), female gender (P<0.0001), hypertension (P< 0.0001) and familiarity (P = 0.0006). Factors reaching statistical significance, determining a worsening of the NFI variable, are only IOP at follow up (P = 0.0159) and depression (P = 0.0104). Conclusion: Results of this study confirm and enforce data coming from most recent studies: IOP remains the main risk factor for glaucoma assess and progression; age and familiarity are great risk factors as underlined in the last decades; female sex can be an important risk factors as emerged only in the last years; arterial hypertension should always be evaluated in timing of our clinic follow up.

Selective Laser Trabeculoplasty Protects Glaucoma Progression in the Initial Primary Open-Angle Glaucoma and Angle-Closure Glaucoma after Laser Peripheral Iridotomy in the Long Term

“…Moreover, according to the recent literature, even the 90°SLT is as effective as 360°SLT in a longterm period [30]. e interpretation of the glaucoma progression is rather challenging as many different factors may affect a glaucoma course [31][32][33]. However, in this study, we compared the glaucoma progression before and after SLT in the same patients.…”

Histological investigation of human glaucomatous eyes: Extracellular fibrotic changes and galectin 3 expression in the trabecular meshwork and optic nerve head

“…Associated risks factors for glaucoma include: age, family history, race, intraocular pressure (IOP) elevation, myopia, central corneal thickness, and glucocorticoid therapy (Coleman and Miglior, 2008;Drance et al, 2001;Park et al, 2016). The incidence of POAG is highest among those of African and Hispanic descent (Abu-Amero et al, 2015;Actis et al, 2016). The most modifiable risk factor is IOP elevation; therefore, current treatment is targeted at reducing IOP with use of pharmacologic agents and surgery (Sit and Asrani, 2008).…”

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns

“…However, there are other risk factors, including older age, disc hemorrhage, large cup-to-disc ratio, beta-zone parapapillary atrophy, and lower systemic blood pressure. [13][14][15][16][17][18][19][20][21][22][23][24] On the other hand, in PACG, the elevation of IOP due to angle closure is usually the exclusive disease mechanism. 12 This difference in disease mechanisms is also supported by genetic findings of different single nucleotide polymorphism associations in PACG and POAG.…”