Risk factors for progression to invasive carcinoma in patients with borderline ovarian tumors

Song, Tae Jong; Yoon, Bo Sung; Lee, Y.Y.; Choi, Chel Hun; Kim, T.J.; Lee, J.W.; Bae, Duk-Soo; Kim, B.G.

doi:10.1016/j.ygyno.2014.03.223

Cited by 4 publications

(11 citation statements)

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“…6,10,16,18,25Y27 The multivariate analysis of our group identified FIGO Ic as the independent risk factor of relapse, although most of reports demonstrated the worse prognosis only for FIGO II/III compared to stage FIGO I. 4,14,16,18,20,23,29 FIGO Ic probably reflects microscopic peritoneal traces of the disease and it may be the potential adverse prognostic factor.…”

Section: Discussionmentioning

confidence: 80%

“…The literature reports that between 2.3% and 3.3% of patients will experience invasive relapse (approximately 30% of all relapses), a figure which agrees with the rate that we are reporting. 5,10,23 However, it should be pointed out that in our patients group, especially in older ones with mucinous histology, the risk of inadequate sampling of the primary tumor and overlooking the invasive foci might exist.…”

Section: Discussionmentioning

confidence: 80%

“…Reported predictive criteria ranged from high FIGO stage, advanced age (965 years), and microinvasion, to elevated CA 125 and invasive implants. 23,28 A third iteration, high FIGO stage (implants), conservative surgery and high CA 125 level, has also been published. 18 A review of the literature shows that the 2 factors most consistently linked to invasive recurrence are invasive implants and residual disease.…”

Section: Discussionmentioning

confidence: 99%

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The Evaluation of Risk Factors Associated With Relapse and Recurrence of Borderline Ovarian Tumors With Long-Term Follow-up

Sobiczewski

Kupryjańczyk²,

Michalski³

et al. 2016

Int J Gynecol Cancer

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Relapses in borderline ovarian tumor are uncommon, in 10% of patients. Invasive relapses are rare, only in 3% of patients, but often with fatal course irrespective of the treatment applied. The most important clinical risk factors of relapse are implants (FIGO II/III), FIGO Ic, and incomplete staging and this patients as well as patients with ascites should be closely followed. Relapses of borderline histology are easily detected and successfully managed by surgery.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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The Evaluation of Risk Factors Associated With Relapse and Recurrence of Borderline Ovarian Tumors With Long-Term Follow-up

Sobiczewski

Kupryjańczyk²,

Michalski³

et al. 2016

Int J Gynecol Cancer

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“…Częstość nawrotów wynosi około 10-11%. Najczęściej są to wznowy typu granicznego, jedynie około 30% nawrotów ma charakter inwazyjny (2,5-3% transformacji złośliwej) (24,(29)(30)(31) . Przegląd piśmiennictwa wskazuje, że czynnikami ryzyka nawrotu -potwierdzonymi w większości badań -są plans is a subject of a great deal of debate (12) .…”

Section: Leczenie Nawrotówunclassified

“…The frequency of relapse is approximately 10-11%. These are usually recurrences of borderline histology, but approximately 30% of them are invasive (2.5-3% of malignant transformation) (24,(29)(30)(31) . Literature reviews show that risk factors of relapse, which are confirmed by most studies, mainly include: advanced disease, presence of implants and non-radical surgery or incomplete staging (24,32) .…”

Section: Treatment Of Recurrencesmentioning

confidence: 99%

Borderline ovarian tumors – diagnosis, treatment and follow-up

Sobiczewski¹,

Kupryjańczyk²,

Śpiewankiewicz³

2015

Curr. Gynecol. Oncol.

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Guzy o granicznej złośliwości stanowią około 20% guzów jajnika. Kryteriami rozpoznania są: brak destrukcyjnego naciekania podścieliska, nawarstwianie komórek nabłonka, umiarkowana aktywność mitotyczna i nienasilona atypia jądrowa. Podstawową metodą leczenia jest chirurgia. Wskazania do leczenia radykalnego to starszy wiek pacjentki i znaczne zaawansowanie choroby. Zakres operacji powinien obejmować usunięcie macicy z przydatkami i wszystkich makroskopowych ognisk nowotworu oraz staging, w którego skład wchodzą: pobranie płynu z otrzewnej, usunięcie sieci, biopsje otrzewnej. Leczenie adiuwantowe nie jest rekomendowane, z wyjątkiem przypadków, w których obecne są wszczepy inwazyjne. Ponad 50% chorych z guzami o granicznej złośliwości to kobiety w wieku rozrodczym-u nich leczenie powinno uwzględniać chęć zachowania płodności. Leczenie oszczędzające polega na usunięciu zmian nowotworowych z zachowaniem macicy i przynajmniej fragmentu jednego jajnika oraz oceną stopnia zaawansowania. Obserwacja po leczeniu powinna być wieloletnia, ponieważ nawroty mogą występować po kilku, a nawet kilkunastu latach. Chore z czynnikami ryzyka (zaawansowany stopień FIGO, obecność implantów, niepełny staging lub pozostawiona masa resztkowa nowotworu) przez 2 pierwsze lata powinny mieć kontrole co 3-4 miesiące, a następnie co 6 miesięcy. Podobną obserwację zaleca się u pacjentek po leczeniu oszczędzającym, zwłaszcza że największy odsetek nawrotów występuje w ciągu 2 lat po operacji. Częstość nawrotów wynosi około 10-11%. Najczęściej są to wznowy typu granicznego, niemniej około 30% nawrotów ma charakter inwazyjny (2,5-3% transformacji złośliwej). Leczenie oszczędzające wiąże się z wyższym ryzykiem nawrotu (nawet 35%), jednak wznowy mają charakter graniczny i są skutecznie leczone chirurgicznie. Wystąpienie wznowy inwazyjnej wiąże się ze złym rokowaniem. Słowa kluczowe: guzy graniczne, leczenie chirurgiczne, nawroty, obserwacja po leczeniu Tumors of borderline malignancy account for approximately 20% of all ovarian tumors. Their diagnostic criteria mainly include: the absence of destructive stromal invasion, stratification of epithelial cells, moderate mitotic activity and non-intensified nuclear atypia. The mainstay of treatment is surgery. Indications for radical treatment include older patient's age and considerable advancement of the disease. The surgery should involve hysterectomy with salpingo-oophorectomy and removal of all macroscopic tumor foci as well as staging, which includes: peritoneal fluid sampling, omentectomy and peritoneal biopsy. Adjuvant treatment is not recommended except for cases with invasive implants. Over 50% of patients with borderline tumors are women at the child-bearing age. In these patients, the wish to preserve fertility should be considered.

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Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors

Ifthikar

Rajanbabu

Nair

et al. 2020

South Asian J Cancer

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Background Borderline ovarian tumors (BOTs) are an intermediate form of neoplasia, between benign and malignant. The aim of this retrospective analysis is to evaluate the clinicopathological characteristic profile of BOTs and to determine the predictors of recurrence in BOTs. Methods A retrospective review of all patients diagnosed, treated, and followed up for BOTs between 2010 and 2017 at Amrita Institute of Medical Sciences, Kerala, India, was conducted. Clinicopathological details and details of management, outcome, and survival were retrieved, and data were analyzed descriptively and for survival. Results A total of 103 patients were identified. During the median follow-up of 46.0 months, 15 (14.6%) patients developed recurrent disease, 6 (5.82%) had recurrence with progression to invasive carcinoma, and 9 had recurrent disease with borderline or benign histology. Mucinous tumors were found to have more recurrences than serous BOT (17.8 vs. 12.3%). Disease-related deaths (5/103 [4.9%]) were observed only in patients with progression to invasive carcinoma. Univariate analysis indicated that staging surgery was the most important prognostic factor that affected the disease-free survival ([DFS] 103 vs. 97 vs. 71 months, respectively, for complete staging vs. fertility-preserving staging vs. conservative surgery; p < 0.05). Conclusions Conservative surgery was associated with a higher risk of recurrence. Fertility-preserving staging surgery is an acceptable option in younger patients. The overall survival is not affected by the mode of surgery.

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Risk factors for progression to invasive carcinoma in patients with borderline ovarian tumors

Cited by 4 publications

References 0 publications

The Evaluation of Risk Factors Associated With Relapse and Recurrence of Borderline Ovarian Tumors With Long-Term Follow-up

The Evaluation of Risk Factors Associated With Relapse and Recurrence of Borderline Ovarian Tumors With Long-Term Follow-up

Borderline ovarian tumors – diagnosis, treatment and follow-up

Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors

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