Risk Factors for Radiographic Progression of Osteoarthritis After Meniscus Allograft Transplantation

Ahn, Ji Hyun; Kang, Ho Won; Yang, Tae Yeong; Lee, Jang Yun

doi:10.1016/j.arthro.2016.04.023

Cited by 19 publications

(14 citation statements)

References 26 publications

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“…Ahn et al [ 4 ] reported the result of 69 MATs carried out by a single surgeon from 2005 to 2012. OA was defined by KL grade changes.…”

Section: Resultsmentioning

confidence: 99%

“…However, there were no differences in Lysholm or Tegner scores between the groups. Ahn et al [ 4 ] concluded that it was possible that MAT reduced the risk of OA but that RCTs were necessary.…”

Section: Resultsmentioning

confidence: 99%

“…Several authors have asserted that meniscectomy leads to OA [ 4 , 13 , 21 ], but the evidence is mixed for several reasons. One is duration of follow-up.…”

Section: Introductionmentioning

confidence: 99%

“…One problem, as Ahn et al [ 4 ] have pointed out, is that patients having meniscectomy may have sustained articular damage in the same event that led to meniscal injury. So OA in a meniscectomised patient may not be due entirely to the absence of a meniscus.…”

Section: Introductionmentioning

confidence: 99%

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Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Waugh

Mistry

Metcalfe

et al. 2019

Knee Surg Sports Traumatol Arthrosc

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Purpose To assess the clinical effectiveness and cost-effectiveness of meniscal allograft transplantation (MAT) after meniscal injury and subsequent meniscectomy. Methods Systematic review of clinical effectiveness and cost-effectiveness analysis. Results There is considerable evidence from observational studies, of improvement in symptoms after meniscal allograft transplantation, but we found only one small pilot trial with a randomised comparison with a control group that received non-surgical care. MAT has not yet been proven to be chondroprotective. Cost-effectiveness analysis is not possible due to a lack of data on the effectiveness of MAT compared to non-surgical care. Conclusion The benefits of MAT include symptomatic relief and restoration of at least some previous activities, which will be reflected in utility values and hence in quality-adjusted life years, and in the longer term, prevention or delay of osteoarthritis, and avoidance or postponement of some knee replacements, with resulting savings. It is likely to be cost-effective, but this cannot be proven on the basis of present evidence. Level of evidence IV. Electronic supplementary material The online version of this article (10.1007/s00167-019-05504-4) contains supplementary material, which is available to authorized users.

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“…Ahn et al [ 4 ] reported the result of 69 MATs carried out by a single surgeon from 2005 to 2012. OA was defined by KL grade changes.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Several authors have asserted that meniscectomy leads to OA [ 4 , 13 , 21 ], but the evidence is mixed for several reasons. One is duration of follow-up.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Waugh

Mistry

Metcalfe

et al. 2019

Knee Surg Sports Traumatol Arthrosc

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“…evaluated the long-term results of meniscus transplantation with successful outcome. However, joint degeneration could not be completely prevented by meniscus transplantation 4 , 5 . Moreover, the availability of allograft is very limited and there are concerns over the possibility of disease transmission 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

The Radiated Deep-frozen Xenogenic Meniscal Tissue Regenerated the Total Meniscus with Chondroprotection

Jiang

Zhang

et al. 2018

Sci Rep

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Meniscal allograft transplantation yields good and excellent results but is limited by donor availability. The purpose of the study was to evaluate the effectiveness of radiated deep-frozen xenogenic meniscal tissue (RDF-X) as an alternative graft choice in meniscal transplantation. The xenogenic meniscal tissues were harvested from the inner 1/3 part of the porcine meniscus and then irradiated and deeply frozen. The medial menisci of rabbits were replaced by the RDF-X. Meniscal allograft transplantation, meniscectomy and sham operation served as controls. Only a particular kind of rabbit-anti-pig antibody (molecular ranging 60–80 kD) was detected in the blood serum at week 2. The menisci of the group RDF-X grossly resembled the native tissue and the allograft meniscus with fibrocartilage regeneration at postoperative 1 year. Cell incorporation and the extracellular matrix were mostly observed at the surface and the inner 1/3 part of the newly regenerated RDF-X, which was different from the allograft. The biomechanical properties of the group RDF-X were also approximate to those of the native meniscus except for the compressive creep. In addition, chondroprotection was achieved after the RDF-X transplantation although the joint degeneration was not completely prevented. To conclude, the RDF-X could be a promising alternative for meniscal transplantation with similar tissue regeneration capacity to allograft transplantation and superior chondroprotection. The potential minor immunological rejection should be further studied before its clinical application.

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Meniscus Transplants

Knapik,

Cole

2023

Knee Arthroscopy and Knee Preservation Surgery

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Risk Factors for Radiographic Progression of Osteoarthritis After Meniscus Allograft Transplantation

Cited by 19 publications

References 26 publications

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

The Radiated Deep-frozen Xenogenic Meniscal Tissue Regenerated the Total Meniscus with Chondroprotection

Meniscus Transplants

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