Risk factors for recurrence of malignant melanoma in patients with negative sentinel lymph node biopsy

Persa, Oana‐Diana; Knuever, Jana; Mauch, Cornelia

doi:10.1111/ddg.13879

Cited by 5 publications

(15 citation statements)

References 15 publications

(24 reference statements)

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“…Consistent with previous publications [4,5,9, 10] on SNB-negative patients (including FN patients), our study revealed increasing Breslow thickness and ulceration to be predictors for distant recurrence. Of SN-negative patients with direct distant metastases, 80% of patients had Breslow thickness ≥ 2 mm, which has been significantly associated with relapse in melanomas in general [2].…”

Section: Discussionsupporting

confidence: 93%

Section: Journal Of Surgery and Research 182supporting

confidence: 74%

“…A FN-SNB has been defined as a recurrence of melanoma in the previously biopsied lymph node basin [4]. False negative results have been reported in 2.0-18.4% of patients [5]. Possible etiologies of FN-SNB include poor radiographic localization of SN, failed pathologic evaluation and failure of surgical technique to identify the SN [4].…”

Section: Introductionmentioning

confidence: 99%

“…The prior research has primarily attempted to identify clinical factors associated with the occurrence of FN-SNB and the impact of FN-SNB on survival outcome [4,6,7,8]. Patients with FN-SNB have had a worse prognosis than patients with positive SNB [5]. However, little attention has been paid to the characteristics and outcomes of patients who experience direct distant metastasis of melanoma following TN-SNB.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of Metastasis and Outcome Following True Negative Sentinel Node Biopsy

Palve¹,

Luukkaala²,

Kääriäinen³

2019

J Surg Res

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Up to 30% of sentinel node-negative patients develop metastases during follow-up. Negative sentinel node biopsies (SNB) can be classified to false (FN) and true negative (TN) categories. Little attention has been paid to the characteristics and outcomes of patients who experience direct distant metastasis following TN-SNB. In this retrospective study of a melanoma database at Tampere university hospital we analyzed characteristics and outcome following metastases after TN-SNB. A total of 506 patients underwent SNB between 2006 and 2016. After review, SNBs were classified FN, TN and true positive (TP). Follow-up was performed until 30.4.2019.Of SN-negative patients, 74 of 396 (19%) developed recurrence, including 17 (4%) local, 22 (6%) regional lymph node (FN) and 35 (9%) direct distant metastases (TN-D). False negative rate was 16% and negative predictive value 93.8%. Locoregional recurrences occurred earlier compared to distal metastases (median of 2.14 /2.93 years). Compared to patients without recurrence, thickness ≥ 2 mm (univariable p<0.001), male gender (p=0.021), nodular melanoma (p=0.001), ulceration (p<0.001) and location in upper limb region (p=0.062) were predictors of TN-D. The 5-year melanoma specific survival in TN-D patients did not differ significantly from TP patients (2.36 /2.26 years).

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Section: Discussionsupporting

confidence: 93%

Section: Journal Of Surgery and Research 182supporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Predictors of Metastasis and Outcome Following True Negative Sentinel Node Biopsy

Palve¹,

Luukkaala²,

Kääriäinen³

2019

J Surg Res

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“…In our study, the location of melanoma in head/neck region was not statistically associated with distant recurrences after true negative SNB in multivariate analysis, which has been found in previous studies with false negative cases [4,5,6,10]. It has been suggested that the increased rate of recurrences despite of negative SNB (false negative) in the head and neck region may be rated to technical factors, including the complex drainage patterns of that region [6].…”

Section: Journal Of Surgery and Research 182supporting

confidence: 67%

Predictors of Metastasis and Outcome Following True Negative Sentinel Node Biopsy

Palve¹,

Luukkaala²,

Kääriäinen³

2019

J Surg Res

View full text Add to dashboard Cite

Up to 30% of sentinel node-negative patients develop metastases during follow-up. Negative sentinel node biopsies (SNB) can be classified to false (FN) and true negative (TN) categories. Little attention has been paid to the characteristics and outcomes of patients who experience direct distant metastasis following TN-SNB. In this retrospective study of a melanoma database at Tampere university hospital we analyzed characteristics and outcome following metastases after TN-SNB. A total of 506 patients underwent SNB between 2006 and 2016. After review, SNBs were classified FN, TN and true positive (TP). Follow-up was performed until 30.4.2019. Of SN-negative patients, 74 of 396 (19%) developed recurrence, including 17 (4%) local, 22 (6%) regional lymph node (FN) and 35 (9%) direct distant metastases (TN-D). False negative rate was 16% and negative predictive value 93.8%. Locoregional recurrences occurred earlier compared to distal metastases (median of 2.14 /2.93 years). Compared to patients without recurrence, thickness ≥ 2 mm (univariable p<0.001), male gender (p=0.021), nodular melanoma (p=0.001), ulceration (p<0.001) and location in upper limb region (p=0.062) were predictors of TN-D. The 5-year melanoma specific survival in TN-D patients did not differ significantly from TP patients (2.36 /2.26 years).

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Post‐operative follow‐up of 150 patients with sentinel lymph node biopsy under tumescence local anesthesia

Eckardt

Häfner

Kofler

et al. 2021

J Deutsche Derma Gesell

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Background: Sentinel lymph node biopsy (SLNB) is useful for staging of patients with melanoma. Although SLNB is mostly performed under general anesthesia (GA), tumescence local anesthesia (TLA) can also be used. However, less data are available regarding feasibility of SLNB under TLA. Here we present a post-operative follow-up of 150 patients. Patients and Methods:We prospectively analyzed data from 150 patients with primary cutaneous malignant melanoma. We assessed pain, post-operative complications and patients' satisfaction after SLNB under TLA.Results: 32 % of the patients reported post-operative pain within the first 48 h after SLNB. Seroma was the most frequent complication, as 29 seromas after SLNB were observed. Wound infection was observed in 3.3 % of the patients. 98.7 % of the patients were satisfied with SLNB under TLA.Conclusions: SLNB under TLA is a safe and feasible option and should be considered for patients with melanoma. Especially with multimorbid or elderly patients, the risks of GA can be avoided.

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Risk factors for recurrence of malignant melanoma in patients with negative sentinel lymph node biopsy

Cited by 5 publications

References 15 publications

Predictors of Metastasis and Outcome Following True Negative Sentinel Node Biopsy

Predictors of Metastasis and Outcome Following True Negative Sentinel Node Biopsy

Predictors of Metastasis and Outcome Following True Negative Sentinel Node Biopsy

Post‐operative follow‐up of 150 patients with sentinel lymph node biopsy under tumescence local anesthesia

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