Risk factors for recurrence of ovarian borderline tumors

Shih, K.K.; Zhou, Qin; Huh, Jae; Morgan, Jessica; Iasonos, Alexia; Aghajanian, Carol; Chi, D.S.; Barakat, Richard R.; Abu‐Rustum, Nadeem R.

doi:10.1016/j.ygyno.2010.11.016

Cited by 93 publications

(72 citation statements)

References 33 publications

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“…In a study on the risk factors for recurrence in BOT, it was shown that higher serum levels of CA 125 and advanced stages of BOT were associated with higher recurrence rate (19). In the current study, there was a marginal significant difference in the stage of disease, between the 2 groups.…”

Section: Discussioncontrasting

confidence: 45%

Recurrence and Fertility Rate in Females with Borderline Ovarian Tumor

Mousavi

Shooshtari

Nassiri

et al. 2017

J Obstet Gynecol Cancer Res

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Background: Currently, the prevalence of borderline ovarian tumors is increasing, and given the higher diagnosis in the third and fourth decades of life, fertility sparing procedures are widely used. There are important consequences in females with borderline ovarian tumors and number of effective factors on recurrence and fertility rate. Methods: In this cohort study, the required information was collected from a file of 43 patients with final pathologic diagnosis of borderline ovarian tumor, who had undertaken fertility sparing surgery at Imam Khomeini Hospital, Tehran University of medical science, and recurrence rate, fertility rate, and the effect of different variables were studied. Results: There were significant correlations between OCP consumption, serous pathology, micro invasion in pathology, advanced stages, and recurrence rate of BOT, while this relationship was not found between parity, surgical methods (laparotomy and laparoscopy), surgical techniques (cystectomy and USO), papillary projection, and recurrence rate. Conclusions: Although the recurrence rate was higher in the current research when compared to other previous studies, yet only in one patient, the pattern of recurrence was invasive epithelial carcinoma, thus in the current study the overall survival did not seem to change. The results of this study on fertility rate are comparable to other studies on this issue. Therefore, these methods are recommended for young patients and emphasis should be place on follow-up.

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Section: Discussioncontrasting

confidence: 45%

Recurrence and Fertility Rate in Females with Borderline Ovarian Tumor

Mousavi

Shooshtari

Nassiri

et al. 2017

J Obstet Gynecol Cancer Res

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“…While lymphadenectomy is part of surgical staging in ovarian cancer, it has not been shown to be prognostically significant in BOT [15]. In many study, lymph node dissection or nodal involvement has no impact on recurrence or survival [13,16,17]. This finding provides further evidence that routine lymphadenectomy may not be necessary with BOT.…”

Section: Resultsmentioning

confidence: 97%

“…These patients were managed with I, conservative treatment is strongly recommended [12]. In the study of Shih et al [13] risk of recurrence was higher in patients who undergo conservative surgery compared with those patients who had radical surgery. Nevertheless, they thought that conservative fertility-sparing surgery remains a reasonable option in the management of BOT.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, Silva et al [23] suggested that patients who were treated by BOTs should be followed for a minimum of 10 years to evaluate for recurrence and for 20 years to evaluate for survival. In the study of Shih et al [13], most of relapses occur during the first 2 years after surgery, are easily detected with transvaginal ultrasound, and can be successfully managed surgically. Patients with borderline replace, have a very good prognosis even if the secondary surgery is conservative.…”

Section: Discussionmentioning

confidence: 99%

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Serous and Mucinous Borderline Ovarian Tumours: Evaluation of Clinical Outcome and Risk Factors for Recurrence

Tounsi¹,

Bouzaine²,

Doghri³

et al. 2017

J Cancer Sci Ther

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Objective: Borderline Ovarian Tumors (BOTs) have a good prognosis; however, a few BOT patients experience the relapse of disease, either borderline or malignant. The aims of this study were to analyze the risk factors of relapse.Methods: This is a retrospective study of 31 patients with confirmed BOTs treated in the Salah Azaiez Oncologic institute between 2005 and 2015.Results: 31 cases were identified; median age was 43 years. Most of the patients 27 (87%) demonstrated stage IA. 8 patients had laparoscopic surgery and they were all treated conservatively. Between 23 patients, which had laparotomy, only two cases underwent conservative surgery and the remaining patients had radical surgery. Five patients had recurrences (16.13%). The relapse was occurred meanly 62.38 months after the primary surgery. Among the 5 recurrent cases, one cancerous transformation and 4 borderline recurrences were detected. 3 recurrences of 8 Laparoscopic surgery group and 2 recurrent cases of 23 laparotomic surgery groups were observed but the statistic result of the relation between laparoscopic approach and higher recurrence rate was not significant (P=0.093). 3 recurrences of 10 conservative surgery group and 2 recurrent cases of 21 radical surgery groups were observed. However, it did not show significant difference (P=0.175). Mean age of disease-recurrence group was 42.8 years whereas the one of non-recurrent group was 46.5 years (P=0.65), age was not risk factor of disease recurrence. Conclusion:Even if age, conservative treatment and laparoscopic technique does not reach the statistic significance as a risk factors for recurrence, we can have a definite conclusion. It is necessary to perform more randomized controlled trials to confirm such an assumption.

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“…In more advanced stages, where invasive implant is absent, lymph nodes are involved or rupture of the cyst has occurred, further studies have shown that chemotherapy has no effect on improving survival and reducing recurrence rate and/or improving the prognosis (39)(40)(41)(42).…”

Section: Postoperative Adjuvant Therapy (Chemotherapy Radiation)mentioning

confidence: 99%

Diagnosis and Management of Borderline Ovarian Tumor Based on the Iranian Guidelines

Akhavan¹,

Mousavi²,

Alibakhshi³

2016

Obstet Gynecol Cancer Res

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Borderline ovarian tumors (BOT) consist of epithelial ovarian lesions that express cytological features of malignancy, but unlike malignant ovarian tumors, do not show obvious stromal invasion. The tumor incidence is between 1.8 and 4.8 per 100,000 females per year. The two major groups of BOT include serous BOT (S-BOT) and mucinous BOT (M-BOT). S-BOTs are divided into two categories: tumors limited to ovary and tumors spreading outside the ovary. M-BOTs are divided into two categories. The more common type is intestinal that constitutes 85% of cases and the second type is endocervical or Mullerian. Mullerian M-BOTs is bilateral in 40% of cases, while it is accompanied by pelvic endometriosis in 20-30% of patients. Microscopic examination by intraoperative frozen section is necessary because macroscopic view of ovarian tumors alone is not reliable. It is better to perform conservative surgery until the final report is ready in patients who wish to preserve their fertility. It is hard to differentiate them based on clinical characteristics. Values of tumor markers including CA125, CA19-9 and CEA in diagnosis of BOT are confirmed. Standard treatment of BOT is surgery as is the case with invasive epithelial ovarian cancer. In the majority of patients referred for BOT, since there is no suspicion of malignancy, staging is not performed. In these cases, making decision to repeat surgery and staging depend on factors such as the type of histology, abdominal exploration results in the previous surgery and probability of the presence of residual tumor.

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Risk factors for recurrence of ovarian borderline tumors

Cited by 93 publications

References 33 publications

Recurrence and Fertility Rate in Females with Borderline Ovarian Tumor

Recurrence and Fertility Rate in Females with Borderline Ovarian Tumor

Serous and Mucinous Borderline Ovarian Tumours: Evaluation of Clinical Outcome and Risk Factors for Recurrence

Diagnosis and Management of Borderline Ovarian Tumor Based on the Iranian Guidelines

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