Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

Rivera, César; Muñoz, Antonieta; Puentes, Carolina; Aguayo, Esteban

doi:10.4067/s0717-95022021000401102

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Such evidence suggests an immunologic role in disease pathogenesis, specifically cell-mediated immunity. It is currently hypothesized that underlying genetic and immunologic factors may predispose an individual to RAS [ 3 , 8 ]. In the setting of triggers, such individual may develop a dysregulated immune response directed toward localized areas of the oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Rahimi,

Mirakhori,

Zelmanovich

et al. 2024

Dermatol Pract Concept

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Introduction: Recurrent aphthous stomatitis (RAS) is a prevalent ulcerative condition affecting oral mucosa. Objectives: A systematic review and meta-analysis was performed to compare the level of neutrophil to lymphocyte ratio (NLR) between individuals with RAS and those who are healthy. Methods: A systematic search for relevant publications before June 21, 2022, was conducted using Web of Science, PubMed, and Scopus. The results were presented as the standardized mean difference (SMD) with a 95% confidence interval (CI), and a random-effects model was used to calculate pooled effects due to the presence of significant heterogeneity. Quality assessment was performed using the Newcastle-Ottawa scale. Results: Overall, 13 article with were included in the analysis. NLR was higher among patients with RAS compared to healthy controls (SMD = 0.50, 95% CI = -0.20 to 0.79, P = 0.001, I2 = 91.5%). In the subgroup analysis based on the study design, it was found that retrospective studies showed higher levels of NLR in patients with RAS compared to healthy controls (SMD = 0.62, 95% CI= 0.16 to 1.08, P < 0.01), but these results were not applied to prospective studies (SMD = 0.35, 95% CI = -0.03 to 0.74, P < 0.07). Conclusion: Elevated neutrophil to lymphocyte ratio revealed crosstalk between systematic inflammation and RAS.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Rahimi,

Mirakhori,

Zelmanovich

et al. 2024

Dermatol Pract Concept

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Painful Recurrent Ulcers in the Mouth: Aphthous Ulcers

Sekar

2023

Clinicopathological Correlation of Oral Diseases

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Aphthous stomatitis - computational biology suggests external biotic stimulus and immunogenic cell death involved

Riveros-Gomez,

Vasquez-Marin,

Huerta-Garcia

et al. 2024

BMC Oral Health

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Background The exact cause of recurrent aphthous stomatitis is still unknown, making it a challenge to develop effective treatments. This study employs computational biology to investigate the molecular basis of recurrent aphthous stomatitis, aiming to identify the nature of the stimuli triggering these ulcers and the type of cell death involved. Methods To understand the molecular underpinnings of recurrent aphthous stomatitis, we used the Génie tool for gene identification, targeting those associated with cell death in recurrent aphthous stomatitis. The ToppGene Suite was employed for functional enrichment analysis. We also used Reactome and InteractiVenn for protein integration and prioritization against a PANoptosis gene list, enabling the construction of a protein-protein interaction network to pinpoint key proteins in recurrent aphthous stomatitis pathogenesis. Results The study’s computational approach identified 1,375 protein-coding genes linked to recurrent aphthous stomatitis. Critical among these were proteins responsive to bacterial stimuli, especially high mobility group protein B1 (HMGB1), toll-like receptor 2 (TLR2), and toll-like receptor 4 (TLR4). The enrichment analysis suggested an external biotic factor, likely bacterial, as a triggering agent in recurrent aphthous stomatitis. The protein interaction network highlighted the roles of tumor necrosis factor (TNF), NF-kappa-B essential modulator (IKBKG), and tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), indicating an immunogenic cell death mechanism, potentially PANoptosis, in recurrent aphthous stomatitis. Conclusion The findings propose that bacterial stimuli could trigger recurrent aphthous stomatitis through a PANoptosis-related cell death pathway. This new understanding of recurrent aphthous stomatitis pathogenesis underscores the significance of oral microbiota in the condition. Future experimental validation and therapeutic strategy development based on these findings are necessary. Supplementary Information The online version contains supplementary material available at 10.1186/s12903-024-04917-z.

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Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

Cited by 3 publications

References 26 publications

Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis

Painful Recurrent Ulcers in the Mouth: Aphthous Ulcers

Aphthous stomatitis - computational biology suggests external biotic stimulus and immunogenic cell death involved

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