Risk factors for renal function impairment in a series of 502 patients born with spinal dysraphisms

Torre, Michele; Guida, Edoardo; Bisio, G.; Scarsi, P. L.; Piatelli, Gianluca; Cama, Armando; Buffa, Piero

doi:10.1016/j.jpurol.2010.02.210

Cited by 41 publications

(22 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neurogenic bladder may be associated with long-term decrease in renal function and therefore it is important to obtain a baseline serum creatinine level as well as to monitor it over time. Torre and colleagues reported an incidence of up to 20% of some degree of renal impairment in 502 patients born with spinal dysraphism and neurogenic bladder [Torre et al 2011]. US of the urinary tract should be obtained shortly after the child is born and repeated after the myelomeningocele closure.…”

Section: Pathological Bladder Function In Infants and Specific Conditmentioning

confidence: 99%

Best practice in the assessment of bladder function in infants

Guerra

Leonard

Castagnetti

2014

Therapeutic Advances in Urology

View full text Add to dashboard Cite

Abstract:The purpose of this article is to review normal developmental bladder physiology in infants and bladder dysfunction in conditions such as neurogenic bladder, posterior urethral valves and high grade vesicoureteric reflux. We contrast the classical concept that bladder function in nontoilet-trained children is thought to be 'reflexive' or 'uninhibited', with the results of more recent research showing that infants most commonly have a stable detrusor. The infant bladder is physiologically distinct from the state seen in older children or adults. The voiding pattern of the infant is characterized by an interrupted voiding stream due to lack of proper urinary sphincter relaxation during voiding. This is called physiologic detrusor sphincter dyscoordination and is different from the pathologic 'detrusor sphincter dyssynergy' seen in patients with neurogenic bladder. Urodynamic abnormalities in neonates born with spina bifida are common and depend on the level and severity of the spinal cord malformation. Upper neuron lesions most commonly lead to an overactive bladder with or without detrusor sphincter dyssynergy while a lower neuron lesion is associated with an acontractile detrusor with possible denervation of the external urinary sphincter. In infants with neurogenic bladder, the role of 'early prophylactic treatment (clean intermittent catheterization and anticholinergics)' versus initial 'watchful waiting and treatment as needed' is still controversial and needs more research. Many urodynamic-based interventions have been suggested in patients with posterior urethral valves and are currently under scrutiny, but their impact on the long-term outcome of the upper and lower urinary tract is still unknown. Cumulative data suggest that there is no benefit to early intervention regarding bladder function in infants with high-grade vesicoureteric reflux.

show abstract

Section: Pathological Bladder Function In Infants and Specific Conditmentioning

confidence: 99%

Best practice in the assessment of bladder function in infants

Guerra

Leonard

Castagnetti

2014

Therapeutic Advances in Urology

View full text Add to dashboard Cite

show abstract

“…The superiority of lumbosacral magnetic resonance imaging for diagnosis, both antenatal and postnatal, and for classification, is generally accepted today. It also readily detects various associated anomalies [34][35][36][37][38][39][40][41][42][43][44][45][46].…”

Section: Crs and Associated Anomalies Of Other Systemsmentioning

confidence: 99%

Etiology of Caudal Regression Syndrome

Semba¹,

Yamamura²

2013

Human Genet Embryol

View full text Add to dashboard Cite

Caudal regression syndrome (CRS) is a rare congenital disorder in which lumbosacral anomalies are combined with anorectal and urogenital malformations. However, the molecular mechanisms of human CRS are not yet known. Trauma, nutritional problems, toxic agents, and genetics are suggested in the etiology of CRS. To the best of our knowledge, linkage studies of families affected exclusively by CRS or total sacral agenesis have not been conducted. In spite of the small number of familial cases reported, some specific genes have been shown to cause defined phenotypes. Environmental factors also may act as an enhancer in the etiology for CRS. There are several mutant mice that are considered as models for CRS, showing characteristic vertebral, anorectal, and urogenital abnormalities. Understanding the mechanisms for CRS development gives us valuable information to understand better what mutations may cause or contribute to CRS in humans. This review highlights the current evidence that pinpoints the link to the etiology of CRS.

show abstract

“…4 Torre et al reported that 3 of 283 cases of meningomyelocele were complicated by unilateral renal agenesis. 5 The genitourinary system and vertebral column are both of mesodermal origin and develop during the same period of embryonic life. During week 5 of embryogenesis, the vertebral bodies begin to develop from the notochord, and the ureteral buds migrate to the metanephrogenic blastema.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

AJP Rep

View full text Add to dashboard Cite

Risk factors for renal function impairment in a series of 502 patients born with spinal dysraphisms

Cited by 41 publications

References 14 publications

Best practice in the assessment of bladder function in infants

Best practice in the assessment of bladder function in infants

Etiology of Caudal Regression Syndrome

Untitled

Contact Info

Product

Resources

About