Risk factors for right colon, left colon and rectal cancers differ between men and women: the population‐based HUNT study in Norway

Brenne, Siv Sellæg; Ness-Jensen, Eivind; Edna, Tom-Harald; Lydersen, Stian; Laugsand, Eivor Alette

doi:10.1111/codi.16324

Cited by 7 publications

(1 citation statement)

References 37 publications

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“…It is generally accepted that the entire colon mucosa is constantly battered by a series of oncogenic factors able to generate mucosal mutations leading to colonic adenomas (28). Therefore, it remains enigmatic why mutated TA and the associated BCNE occupies barely a few mm of the colonic mucosa.…”

Section: Discussionmentioning

confidence: 99%

Further Study on Field Cancerization in the Human Colon

Rubio

Lang-Schwarz

2022

Anticancer Res

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Background/Aim: Nearly 70 years ago, Slaughter launched the hypothesis of field cancerization for oral carcinomas; that hypothesis was subsequently also claimed for carcinomas in other organs. We previously found in the colon mucosa adjacent to nonpolypoid adenomas, branching crypts lined by normal epithelium (BCNE). Here, we explored whether BCNE could also be found in the colon mucosa adjacent to sporadic polypoid tubular adenomas (TA), the most prevalent of all colon adenomas. Patients and Methods: Nondysplastic mucosa adjacent to TA was found in 103 out of 131 TA. All BCNE adjacent to TA were recorded. Results: In 98 (95.1%) out of 103 TA having nondysplastic adjacent mucosa, 645 BCNE were registered: 82.6% were in asymmetric branching and 17.4% in symmetric branching. Thus, BCNE in asymmetric branching predominated. The frequency of BCNE adjacent to TA was influenced by the adenoma size and degree of dysplasia severity. Contrarywise, the frequency of BCNE adjacent to TA was neither influenced by the age or sex of the patients, nor by the colon localization of TA. Conclusion: BCNE often occur in the normal mucosa adjacent to TA. BCNE emerge as integral components of TA. The majority of the BCNE were in asymmetric branching, considered as aberrations of cryptogenesis. We propose that the accretion of asymmetric BCNE adjacent to TA supports Slaughter's hypothesis of field cancerization.

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Section: Discussionmentioning

confidence: 99%

Further Study on Field Cancerization in the Human Colon

Rubio

Lang-Schwarz

2022

Anticancer Res

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Analysis of prognostic factors in different grades of histologic differentiation in colorectal cancer patients receiving preoperative neoadjuvant chemotherapy and establishment of prognostic nomograms for moderately differentiated grade

Luo,

et al. 2023

Int J Colorectal Dis

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External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study

Brenne,

Ness-Jensen,

Laugsand

2024

Int J Colorectal Dis

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Purpose To mitigate the increasing colorectal cancer (CRC) incidence globally and prevent CRC at the individual level, individual lifestyle information needs to be easily translated into CRC risk assessment. Several CRC risk prediction models exist and their clinical usefulness depends on their ease of use. Our objectives were to assess and externally validate the LiFeCRC score in our independent, unselected population and to investigate the use of simpler food frequency measurements in the score. Methods Incidental colon and rectal cancer cases were compared to the general population among 78,580 individuals participating in a longitudinal health study in Norway (HUNT). Vegetable, dairy product, processed meat and sugar/confectionary consumption was scored based on food frequency. The LiFeCRC risk score was calculated for each individual. Results Over a median of 10 years following participation in HUNT, colon cancer was diagnosed in 1355 patients and rectal cancer was diagnosed in 473 patients. The LiFeCRC score using food frequencies demonstrated good discrimination in CRC overall (AUC 0.77) and in sex-specific models (AUC men 0.76 and women 0.77) in this population also including individuals ≥ 70 years and patients with diabetes. It performed somewhat better in colon (AUC 0.80) than in rectal cancer (AUC 0.72) and worked best for female colon cancer (AUC 0.81). Conclusion Readily available clinical variables and food frequency questions in a modified LiFeCRC score can identify patients at risk of CRC and may improve primary prevention by motivating to lifestyle change or participation in the CRC screening programme.

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Risk factors for right colon, left colon and rectal cancers differ between men and women: the population‐based HUNT study in Norway

Cited by 7 publications

References 37 publications

Further Study on Field Cancerization in the Human Colon

Further Study on Field Cancerization in the Human Colon

Analysis of prognostic factors in different grades of histologic differentiation in colorectal cancer patients receiving preoperative neoadjuvant chemotherapy and establishment of prognostic nomograms for moderately differentiated grade

External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study

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