Risk factors for salvage surgery failure in oral cavity squamous cell carcinoma

Matsuura, Danielli; Valim, Tiago Dias; Kulcsar, Marco Aurélio Vamondes; Pinto, Fábio Roberto; Brandão, Lenine Garcia; Cernea, Cláudio Roberto; Matos, Leandro Luongo de

doi:10.1002/lary.26935

Cited by 43 publications

(35 citation statements)

References 29 publications

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“…OS, DSS DFS rates were 31.7%, 36.2%, and 35.0% respectively. The presence of lymph node metastasis and positive surgical margins were the only independent factors associated with both recurrence rates and mortality [ 32 ]. In a series of 185 patients treated for recurrent oral SCC, (17 patients were excluded from analysis because developing recurrence within six months after completion of the primary treatment), the five-year OS rate was 31.9%.…”

Section: Oncological Outcomesmentioning

confidence: 99%

“…Resection margin status and extracapsular spread (ECS) are significantly related to survival following SS after CRT [ 3 , 8 , 43 ]. Many studies have identified positive margins as a risk factor of poor oncologic outcome [ 9 , 23 , 24 , 25 , 26 , 32 , 40 ]. The presence of positive margins after SS, has been reported in 18.3–22% of patients [ 3 , 9 ] and it is a strong independent factor for recurrence in many studies [ 9 , 14 , 32 ].…”

Section: Identification Of Patients At High Risk Of Re-recurrence mentioning

confidence: 99%

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The Current Role of Salvage Surgery in Recurrent Head and Neck Squamous Cell Carcinoma

Hamoir

Schmitz

Suárez

et al. 2018

Cancers

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Chemoradiotherapy has emerged as a gold standard in advanced squamous cell carcinoma of the head and neck (SCCHN). Because 50% of advanced stage patients relapse after nonsurgical primary treatment, the role of salvage surgery (SS) is critical because surgery is generally regarded as the best treatment option in patients with recurrent resectable SCCHN. Surgeons are increasingly confronted with considering operation among patients with significant effects of failed non-surgical primary treatment. Wide local excision to achieve clear margins must be balanced with the morbidity of the procedure, the functional consequences of organ mutilation, and the likelihood of success. Accurate selection of patients suitable for surgery is a major issue. It is essential to establish objective criteria based on functional and oncologic outcomes to select the best candidates for SS. The authors propose first to understand preoperative prognostic factors influencing survival. Predictive modeling based on preoperative information is now available to better select patients having a good chance to be successfully treated with surgery. Patients with a high comorbidity index, advanced oropharyngeal or hypopharyngeal primary tumors, and both local and regional recurrence have a very limited likelihood of success with salvage surgery and should be strongly considered for other treatments. Following SS, identifying patients with postoperative prognostic factors predicting high risk of recurrence is essential because those patients could benefit of adjuvant treatment or be included in clinical trials. Finally, defining HPV tumor status is needed in future studies including recurrent oropharyngeal SCC patients.

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Section: Oncological Outcomesmentioning

confidence: 99%

Section: Identification Of Patients At High Risk Of Re-recurrence mentioning

confidence: 99%

The Current Role of Salvage Surgery in Recurrent Head and Neck Squamous Cell Carcinoma

Hamoir

Schmitz

Suárez

et al. 2018

Cancers

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“…The deadliest aspect of oral cancer is metastasis 3,4 . Once the tumor is formed, cells may begin to break off from this tumor and migrate to other parts of the body 5 . These cancer cells that travel through the body established new tumors in remote locations like lung metastasis 6,7 .…”

Section: Introductionmentioning

confidence: 99%

“…These cancer cells that travel through the body established new tumors in remote locations like lung metastasis 6,7 . Less than 50% of patients will survive for 5 years, and majority of patients with metastatic OSCC die within 1 year 5,8 . Understanding the molecular mechanisms underpinning OSCC metastasis is of crucial importance to the development of specific diagnostic methods and individualized therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

et al. 2020

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Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. Circular RNA (circRNA) has been increasingly recognized as a crucial contributor to carcinogenesis. circRNA_0000140 has been aberrantly expressed in OSCC, but its role in tumor growth and metastasis remains largely unclear. Sanger sequencing, actinomycin D, and RNase R treatments were used to confirm head-to-tail junction sequences and the stability of circ_0000140. In vitro cell activities, including proliferation, migration, invasion, and apoptosis, were determined by colony formation, transwell, and flow cytometry assays. The expression levels of circ_0000140, Hippo signaling pathway, and serial epithelial-mesenchymal transition (EMT) markers were measured by quantitative real-time PCR, western blotting, immunofluorescence, and immunohistochemistry. Dual luciferase reporter assays and Argonaute 2-RNA immunoprecipitation assays were performed to explore the interplay among circ_0000140, miR-31, and LATS2. Subcutaneous tumor growth was observed in nude mice, in which in vivo metastasis was observed following tail vein injection of OSCC cells. circ_0000140 is derived from exons 7 to 10 of the KIAA0907 gene. It was down-regulated in OSCC tissues and cell lines, and correlated negatively with poor prognostic outcomes in OSCC patients. Gain-offunction experiments demonstrated that circ_0000140 enhancement suppressed cell proliferation, migration, and invasion, and facilitated cell apoptosis in vitro. In xenograft mouse models, overexpression of circ_0000140 was able to repress tumor growth and lung metastasis. Furthermore, mechanistic studies showed that circ_0000140 could bind with miR-31 and up-regulate its target gene LATS2, thus affecting OSCC cellular EMT. Our findings demonstrated the roles of circ_0000140 in OSCC tumorigenesis as well as in metastasis, and circ_0000140 exerts its tumor-suppressing effect through miR-31/LATS2 axis of Hippo signaling pathway in OSCC.

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“…Treatment of OSCC is primarily surgical and involves en bloc resection of the primary tumor, with or without cervical nodal dissection, based on the presence or occult risk of regional metastases. However, successful resection remains challenging, with locoregional recurrence rates of 25% to 50% and 5‐year overall survival of 64.8% …”

Section: Introductionmentioning

confidence: 99%

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

et al. 2019

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Objective: To discuss the current available techniques for intraoperative margin assessment in the surgical treatment of oral squamous cell carcinoma (OSCC) through a review of the available literature.Methods: A systematic review was undertaken of the available English literature between 2008 through 2018 regarding surgical margins in OCSS. A total of 893 relevant articles were returned; 144 met criteria for review; and 64 articles were included.Results: In this review, we discuss the data surrounding the use of frozen section in OCSS. Additionally, alternative techniques for margin assessment are discussed, including Mohs, molecular analysis, nonfluorescent dyes, fluorescent dyes, autofluorescent imaging, narrow-band imaging, optical coherence tomography, confocal microscopy, high-resolution microendoscopy, and spectroscopy. For each technique, particular emphasis is placed on the local recurrence, disease-free survival, and overall survival rates when available.Conclusion: This review provides support for the practice of specimen-driven margin assessment when using frozen section analysis to improve the utility of the results. Finally, several alternatives for intraoperative margin assessment currently under investigation, including pathologic, wide-field imaging and narrow-field imaging techniques, are presented. We aim to fuel further investigation into methods for margin assessment that will improve survival for patients with OSCC through a critical analysis of the available techniques.

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Risk factors for salvage surgery failure in oral cavity squamous cell carcinoma

Abstract: 2b. Laryngoscope, 128:1113-1119, 2018.

Cited by 43 publications

References 29 publications

The Current Role of Salvage Surgery in Recurrent Head and Neck Squamous Cell Carcinoma

The Current Role of Salvage Surgery in Recurrent Head and Neck Squamous Cell Carcinoma

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

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