Risk Factors for Seborrhoeic Dermatitis Flares: Case-control and Case-crossover Study

Abstract

Patients with flares of seborrhoeic dermatitis were compared with control outpatients seen during the same time-period in a case-control study, and with themselves while in remission in a case-crossover study. All patients consulted the same office-based dermatologist. During the study period, 189 cases and 189 controls were included in the case-control study, and 81 cases in the case-crossover study. Multivariate analysis was performed. Case-control study results were the following: past history of tobacco consumption (odds ratio (OR) 2.2 (95% confidence interval (CI) 1.1–4.6)), conflict as a dispute during the past month (OR 10.6 (95% CI 1.0–114.3)), alcohol consumption on a regular basis (OR 10.2 (95% CI 2.0–52.6)), and higher level of stress during the past month (OR 8.2 (95% CI 3.4–19.9)). Case-crossover study results were the following: higher level of stress during the past month (OR 4.5 (1.7–12.2)), association borderline significant for higher level of alcohol consumption (OR 5.4 (0.8–34.9)). These risk factors for flares of seborrhoeic dermatitis should be taken into account carefully in the daily management of seborrhoeic dermatitis.

Investigation of the relationship between seborrheic dermatitis and metabolic syndrome parameters

“…34 Male gender, age, obesity, skin type, education, HT, depression, stress, and diet are risk factors that facilitate the formation of SD. 35 Although SD is a dermatosis mostly seen in men, it was more common in women in this study, similar to that in Iraq. 28 Regardless of age, there is an increase in the occurrence of MetS as a result of hormonal changes during menopause.…”

“…Lancor et al detected the most involvement in the nasolabial, eyebrow, and scalp in SD patients aged 30–54 years 35 . In our study, there was scalp involvement in 72.2% ( n = 39) of the patients in general.…”

Relationship between disease severity, perceived stress, and depression in patients with seborrheic dermatitis

“…Koo and Lee, who classified psychodermatological diseases, included seborrheic dermatitis in the category of psychophysiological disorders referring to the precipitation or exacerbation of a skin disease by psychological stress [25]. Many studies have shown the negative effect of stress on the severity of seborrheic dermatitis and frequency of disease attacks [12,[26][27][28][29]. It is known that the quality of life is significantly affected in this chronic disease with recurrent attacks (30)(31)(32)(33).…”

Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

“…Numerous studies found significant associations between regular alcohol use and an increased prevalence of SD [17,18,19,20] Further, increased alcohol consumption is associated with a greater risk of SD flares (OR = 5.4, P = .08) [20]. Sharma et al evaluated quantity of alcohol consumed in a week, duration of alcohol intake, and SD duration in 196 males, who reported drinking ≥200 mL of pure alcohol weekly, that were referred for a dermatologic consult [17].…”

“…Some studies demonstrate no relationship between SD and BMI [10, 19,20]; however, a casecontrol study by Akbas et al (n = 101) compared SD patients with age and sex matched controls and found that SD was associated with higher BMI when compared to controls (P = .002) [22]. Erdogan et al (n = 103) also evaluated the relationship between BMI, subjective SD severity, and SDASI score in a case control study with SD patients and age, sex, and BMI matched controls [23].…”