Risk factors for seizure recurrence in children with febrile seizures: A pooled analysis of individual patient data from five studies

Offringa, Martin; Bossuyt, Patrick M.; Lubsen, Jacobus; Ellenberg, Jonas H.; Nelson, Karin B.; Knudsen, Finn Ursin; Annegers, John F.; El-Radhi, A. Sahib; Habbema, J. Dik F.; Derksen‐Lubsen, Gerarda; Hauser, W. Allen; Kurland, Leonard T.; Banajeh, Salem; Larsen, Svend

doi:10.1016/s0022-3476(05)83136-1

Cited by 178 publications

(131 citation statements)

References 16 publications

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“…Association between RFS and a relatively low fever at the time of the initial CFS had been reported by other studies. 9,20 This was consistent with a threshold model, i.e. children whose seizures occurred with relatively low fever required less provocation to have a seizure than those whose initial seizures occurred at higher temperatures.…”

Section: Discussionsupporting

confidence: 79%

Predictors for the recurrent febrile seizures after the first complex febrile seizures

Tanjung¹,

Mangunatmadja²,

Sastroasmoro³

et al. 2016

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Background Complex febrile seizures (CFS) have been shownto be related to recurrence and epilepsy. Many studies were doneto determine the predictors of recurrence in both simple and com-plex febrile seizures. To our knowledge until now there is no pub-lished data that specially looks for predictors of recurrence after afirst CFS.Objective To find out clinical and demographical characteristicsof a first CFS and to define the predictors for the recurrent febrileseizures.Methods Prospective survival analysis study was done in chil-dren with first CFS who visited Cipto Mangunkusumo Hospital,Jakarta, over 14 months periods. The predictors for developmentof recurrence were analyzed by SPSS for Windows 11.5 usingKaplan-Meier test and Cox regression model with a level of signifi-cance <0.05.Results There were 62 subjects completed this study. Male-to-female ratio was 1.4:1. The mean age at onset was 18.2 months.Recurrence occurred in 9 subjects (14.5%). Body temperaturebetween 38-38.5°C (7 of 26 subjects, P=0.02), upper motor neu-ron type of delayed development (3 of 7 subjects, P=0.03), andepileptic history in the family (2 of 2 subjects, P<0.05) were asso-ciated with recurrence in bivariate analysis. In multivariate analy-sis only body temperature between 38-38.5°C (HR 1.6, 95% CI1.0;23.9) and epileptic history in the family (HR 16.9, 95% CI2.8;101.4) were identified as predictors.Conclusion Low body temperature at the first seizures and epi-leptic history in the family were independent predictors for the re-currence after a first CFS

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Section: Discussionsupporting

confidence: 79%

Predictors for the recurrent febrile seizures after the first complex febrile seizures

Tanjung¹,

Mangunatmadja²,

Sastroasmoro³

et al. 2016

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“…Factors increasing the risk of febrile seizure recurrences include young age at onset, family history of febrile seizures, previous recurrent febrile seizures, time lapse since previous seizure Ͻ6 months, temperature Ͻ40.0°C at initial febrile seizure, multiple type initial febrile seizure, and frequent febrile illnesses. [2][3][4][5][6][7][8] In recent years, the prevention of recurrent febrile seizures has become a debatable issue; prevention may not be necessary because almost all febrile seizures are not injurious to the child. 9 -11 However, prevention of seizure recurrences serves two useful purposes: meeting parental fear of recurrent febrile seizures in general 12,13 and reducing the small risk of a long-lasting and eventually injurious recurrent seizure.…”

mentioning

confidence: 99%

Randomized, Controlled Trial of Ibuprofen Syrup Administered During Febrile Illnesses to Prevent Febrile Seizure Recurrences

et al. 1998

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ABSTRACT. Objectives. Febrile seizures recur frequently. Factors increasing the risk of febrile seizure recurrence include young age at onset, family history of febrile seizures, previous recurrent febrile seizures, time lapse since previous seizure <6 months, relative low temperature at the initial seizure, multiple type initial seizure, and frequent febrile illnesses. Prevention of seizure recurrences serves two useful purposes: meeting parental fear of recurrent febrile seizures in general and reducing the (small) risk of a long-lasting and eventually injurious recurrent seizure. In daily practice, children with febrile seizures often are treated with antipyretics during fever to prevent febrile seizure recurrences. Thus far, no randomized placebo-controlled trial has been performed to assess the efficacy of intermittent antipyretic treatment in the prevention of seizure recurrence.Methods. We performed a randomized, doubleblind, placebo-controlled trial. Children 1 to 4 years of age who had had at least one risk factor for febrile seizure recurrence were enrolled. They were randomly assigned to either ibuprofen syrup, 20 mg/mL, 0.25 mL ‫؍(‬ 5 mg) per kilogram of body weight per dose, or matching placebo, to be administered every 6 hours during fever (temperature, >38.5°C). Parents were instructed to take the child's rectal temperature immediately when the child seemed ill or feverish and to promptly administer the study medication when the temperature was >38.5°C. Doses were to be administered every 6 hours until the child was afebrile for 24 hours. The parents were instructed not to administer any other antipyretic drug to the child. For measuring rectal temperature, a Philips HP5316 digital thermometer (Philips, Eindhoven, The Netherlands) was distributed. During subsequent treatment of the fever episode, parents had to call the investigator at least once each day to notify the investigator in case of febrile seizure recurrence. The investigator could be contacted by parents 24 hours per day.The primary outcome was the first recurrence of a febrile seizure. Kaplan-Meier curves and Cox regression were used for the statistical analysis. The treatment effect on the course of the temperature was assessed using analysis of covariance, with temperature at fever onset as covariate. Two analyses were performed. In an intention-to-treat analysis, all first recur-

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“…1 Literatürde belirtildiği gibi bizim çalış-mamızda da en fazla JTK tarzı nöbet görülmüş-tür. 22,25,36 Çalışmamızda, hastaların 61 (%48,4)'inde rekürrens görülmüştür. Tek nöbet geçirenlerin oranı %51,6, iki nöbet geçirenlerin oranı %22,2, üç nöbet geçirenlerin oranı %7,9, dört ve üzerinde nöbet geçirenlerin oranı ise %18,3 olarak bulunmuştur.…”

Section: Discussionunclassified

“…36 Berg ve ark. ise FK rekür-rens oranlarını ilk FK'si bir yaş altında olanlarda %39,2, 18 ayın altında olanlarda %48,4, 12 ayın üs-tünde olanlarda %29,6 ve 18 ayın üstünde olanlarda %22,5 olarak bulmuşlardır.…”

Section: Discussionunclassified

Febrile Seizure Prevalence in Children in the Erzurum Provincial Center

Erdil¹,

Tan²,

Turan³

et al. 2016

Turkiye Klinikleri J Pediatr

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Risk factors for seizure recurrence in children with febrile seizures: A pooled analysis of individual patient data from five studies

Cited by 178 publications

References 16 publications

Predictors for the recurrent febrile seizures after the first complex febrile seizures

Predictors for the recurrent febrile seizures after the first complex febrile seizures

Randomized, Controlled Trial of Ibuprofen Syrup Administered During Febrile Illnesses to Prevent Febrile Seizure Recurrences

Febrile Seizure Prevalence in Children in the Erzurum Provincial Center

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