Risk Factors for Sessile Serrated Adenomas

Anderson, Joseph C.; Rangasamy, Priya; Rustagi, Tarun; Myers, Matthew; Sanders, Melinda; Vaziri, Haleh; Wu, George; Birk, John; Protiva, Petr

doi:10.1097/mcg.0b013e318207f3cf

Cited by 106 publications

(102 citation statements)

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“…There may be an increase of hypermethylation abnormalities in women smokers [13,[27][28][29], which may increase the risk for proximal neoplasia as well as serrated polyps. A recent case control study examining SSAs, most of which were proximal, observed an increased risk associated with smoking [30]. To examine this issue, we examined the risk for large proximal serrated lesions in our sample and observed that the risk for these lesions was increased in female smokers only.…”

Section: Discussionmentioning

confidence: 88%

Smoking and the Association of Advanced Colorectal Neoplasia in an Asymptomatic Average Risk Population: Analysis of Exposure and Anatomical Location in Men and Women

et al. 2011

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Section: Discussionmentioning

confidence: 88%

Smoking and the Association of Advanced Colorectal Neoplasia in an Asymptomatic Average Risk Population: Analysis of Exposure and Anatomical Location in Men and Women

et al. 2011

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“…18 On the contrary, Huang et al found no association between smoking and advanced serrated polyps. 19 Current smoking was associated with a significantly higher polyp number in patients with serrated polyposis, 16 and the prevalence of current smokers was higher among serrated polyposis patients than in the general population.…”

Section: Discussionmentioning

confidence: 97%

Type 1 serrated polyposis represents a predominantly female disease with a high prevalence of dysplastic serrated adenomas, without germline mutation in MUTYH, APC, and PTEN genes

et al. 2016

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Aim: The aim of this article is to clarify the epidemiologic, clinical, endoscopic, biological and genetic characteristics of type 1 serrated polyposis patients. Patients and methods: Consecutive patients responding to the WHO definition of type 1 serrated polyposis in one reference center for polyposis patients accepted genetic counseling. Detailed data on previous endoscopies, histology, and life habits were recorded, after informed consent, germline analysis of MUTYH, APC, and PTEN germline mutations. Molecular biology was tested on available fixed tissue from different lesion types. Results: We included 29 patients (mean age 53.5 years, 21 women (72.4%)), four with a personal history of colorectal cancer (CRC), with a mean of 11.6 SSAs, with associated hyperplastic polyps in 93.1% and adenomas in 82.8%. SSAs showed no dysplasia in 46.9% of lesions (three of 29 patients), LGD in 51.9% (22/29 patients), and HGD in 1.2% (four of 29 patients). Dysplasia was more frequent in proximal SSAs and in women. Colectomy 15 patients (51.7%), upper digestive neoplasms: eight patients (27.5%); smokers: 24 patients (82.8%); family history of CRC: 16 patients (55.2%). Biology: MSI-H phenotype in one SSA, V600E BRAF mutation in 95% of SSAs; MGMT hypermethylation in three of 17 SSAs. No germline mutation was detected in MYH, APC or PTEN genes. Conclusion: Type 1 serrated polyposis corresponds to a majority of women, with a high prevalence of smokers, a high prevalence of dysplastic serrated adenomas, particularly in females, without identified germline mutation in targeted predisposing genes.

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“…The association between smoking and SP risk was assessed by 29 articles which reported information from 29 studies, of which 26 articles investigated HP/SP risk 24,25, and six investigated SSA/P risk [29][30][31][51][52][53] . Most studies originated from the USA, five from Europe, and five in Asian populations (Supplementary Table 1(a)).…”

Section: Smokingmentioning

confidence: 99%

Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis

Bailie¹,

Loughrey²,

Coleman³

2017

Gastroenterology

151

127

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Risk Factors for Sessile Serrated Adenomas

Abstract: Our data suggest that smoking at least 20 pack-years is strongly associated with any and large SSAs. In addition, diabetes mellitus and obesity seem to be associated with SSAs as well. Our data has implications for CRC screening.

Cited by 106 publications

References 0 publications

Smoking and the Association of Advanced Colorectal Neoplasia in an Asymptomatic Average Risk Population: Analysis of Exposure and Anatomical Location in Men and Women

Smoking and the Association of Advanced Colorectal Neoplasia in an Asymptomatic Average Risk Population: Analysis of Exposure and Anatomical Location in Men and Women

Type 1 serrated polyposis represents a predominantly female disease with a high prevalence of dysplastic serrated adenomas, without germline mutation in MUTYH, APC, and PTEN genes

Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis

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