Risk Factors for Severe COVID-19 in Children

Graff, Kelly E; Smith, Christiana; Silveira, Lori; Jung, Sarah; Curran-Hays, Shane; Jarjour, Jane; Carpenter, Lauren; Pickard, Kasey; Mattiucci, Michael; Fresia, Joellen; McFarland, Elizabeth J.; Dominguez, Samuel R.; Abuogi, Lisa

doi:10.1097/inf.0000000000003043

Cited by 222 publications

(322 citation statements)

References 43 publications

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“…A previous analysis of 454 patients younger than 21 years at Children’s Hospital Colorado found asthma to be a risk factor for hospitalization and respiratory support but not critical care. 7 Current evidence suggesting asthma as a risk factor for severe COVID-19 illness among adults is mixed. 31 Thus, the role of asthma in severity of infection for both children and adults remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…2 Prior literature identified risk factors for severe COVID-19 illness in children, including being younger than 1 year or having an underlying medical condition, such as congenital heart disease, asthma, obesity, diabetes, or neurologic conditions. [2][3][4][5][6][7] Approximately 1 in 4 US children have a chronic condition, including asthma, obesity, and behavioral or learning disorders. 8 Previous studies on risk factors among children were limited by small sample sizes that affected the study's ability to detect statistically significant associations and by a limited ability to follow up children over multiple encounters.…”

Section: Introductionmentioning

confidence: 99%

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Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

et al. 2021

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Key Points Question Among children with a COVID-19 diagnosis, what conditions are common, and which are associated with severe COVID-19 illness? Findings In this cross-sectional study of 43 465 patients aged 18 years or younger with COVID-19, more than one-quarter had 1 or more underlying condition; asthma, obesity, neurodevelopmental disorders, and certain mental health conditions were most common. Certain conditions as well as medical complexity were associated with a higher risk of severe COVID-19 illness. Meaning These findings expand the knowledge available regarding children with COVID-19 and could inform pediatric clinical practice and public health priorities, such as prevention and mitigation of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

et al. 2021

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“…Risk factors for severe disease were analyzed and in multivariable analyses, age 0-3 months or >20 years and comorbidities, asthma, gastrointestinal condition and diabetes were the predictors of severe disease in children. [30] In the present study more than 18 years were not included, but more than 47% of severe cases were in the age group 10 to 18 years and more than 36% were in the age group 5 to 10 years. This might reflect that chances of severe disease increase with the increasing age.…”

Section: Discussionmentioning

confidence: 71%

Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University

Haque¹,

Laila²,

Al-Mamun³

et al. 2021

AJP

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Background: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. Covid-19 has spread around Bangladesh and children are also being infected with comparatively fewer symptoms and lower case-fatality rates. Objectives: To assess the clinical profile, disease severity, presence of co-morbidities and outcome of pediatric COVID-19 patients. Methods: This prospective observational study was conducted in the fever clinic and the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU). Data were collected from the confirmed cases by using a structured questionnaire by face to face interview and also over telephone at 1 st visit and at 2 nd and 8 th week of disease course. Collected data were analyzed using appropriate statistical tests. Result: Among 2091 suspected COVID 19 cases attending fever clinic and department of Pediatrics, 462 (22.09%) were real time polymerized chain reaction (RT PCR) COVID 19 positive. Of them 377 (81.60%) responded to the questionnaire and subsequent follow up. Highest numbers of cases were found in June 2020. More than 60% of cases were within the age group of 10 to 18 years and 3.44% were infants. Male: female ratio was 1.04:1. Associated co-morbid conditions were present in 21.48% patients. Fever was the most common (72.67%) clinical feature followed by others. Incidences of severe and critical illness were more in older children. Most of the moderate cases and all of the severe and critical COVID cases were managed in the inpatient department including Pediatric intensive care unit. Among them, 100% required oxygen therapy, 72.41% needed oral or IV steroids, 8.6% and 6.9% needed intravenous immunoglobulin and biological agents (Tocilizumab) respectively. Seventeen patients (4.5%) recovered with some complications. Conclusions: Among suspected cases 22% were RT-PCR positive. Majorities were in the older age group and most of the moderate and all the severe and critical cases also belonged to older age group. Most of the cases (94.42%) recovered without complication and 4.5% recovered with some complications. Mortality was 1.06%.

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“… 10 , 11 , 12 History of prematurity, asthma, diabetes, immunocompromised state, and gastrointestinal disease are associated with increased odds of admission. 13 Furthermore, those with asthma and gastrointestinal disease are more likely to require respiratory support. 13 Obesity is associated with higher risk of severe COVID-19.…”

Section: Covid-19 In Children and Adolescentsmentioning

confidence: 99%

COVID-19 in Pediatrics

Case¹,

Son²

2021

Rheumatic Disease Clinics of North America

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Risk Factors for Severe COVID-19 in Children

Abstract: COV-2 positive childrena The top three diagnoses were included under each system. If only two diagnoses are listed, there were only two reported. Percentages may add up to greater than 100% due to some patients with multiple diagnoses

Cited by 222 publications

References 43 publications

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University

COVID-19 in Pediatrics

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