Risk factors for severity of coronary artery disease in patients with cardiovascular disease

Samanidis, George; Gkogkos, Anastasios; Bousounis, Stefanos; Zoumpourlis, Panagiotis; Perrea, Despina

doi:10.1016/j.atherosclerosis.2021.06.308

Cited by 2 publications

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“…The prevalence of CAD varies according to age, gender, socioeconomic position, and other factors. Atherosclerosis is defined by a number of linked processes, including lipid dysregulation, thrombosis, inflammation, vascular smooth cell activation, platelet activation, endothelial dysfunction, oxidative stress, and genetic factors (26,27). According to the current study's findings, the average age of the patients was 58.125 years, which was significantly older than the average age of PC 42.57 years and NC 40.77 years.…”

Section: Discussionmentioning

confidence: 56%

A Role for Inflammatory Il-6 in the Development of Coronary Artery Disease: a Case Control Study at Al-Qadisiyah Governorate, Iraq

Alzamily¹,

Al-Delfi²,

Al-Barqaw³

2022

MMSL

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Background: Disruption of the IL-6 axis can result in the beginning or progression of a variety of disease states, including cardiovascular diseases. Because of IL-6's pathogenic function, pharmacologic manipulation of the IL-6 axis is a sensible therapeutic strategy; nevertheless, various expected, yet frequently overlooked, effects on tissues and organs other than blood vessels may also occur. The study's goal is as follows: The purpose of this study is to see how inflammatory Interleukin-6 affects the development of coronary artery disease.Materials and Methods: Serum IL-6 level was estimated using Elabscience ® kits. A case-control study included 30 CAD patients, 30 positive controls (PC) [(have family history for CAD)], and 30 negative controls (NG) [they have no family history for CAD]. Ranged from 30 to 81 years old. Patients with acute or chronic illnesses such as liver disease, renal disease, thyroid function disorders, COVID-19, and autoimmune disease were excluded from the study. During the period from December 2020 to May 2021. Our study was included other factors such as ages, genders, smoking, family history, antihypertensive drugs or drugs for other diseases, body mass index (BMI) which were assessed.Results: The results of this study show increased levels of IL-6 in patients with CAD compared with the PC and NC These results showed a highly significant difference (p < 0.0001) in the concentrations compared with PC and NC.Conclusions: IL-6 could be one of the prognostic signs of CAD.

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Section: Discussionmentioning

confidence: 56%

A Role for Inflammatory Il-6 in the Development of Coronary Artery Disease: a Case Control Study at Al-Qadisiyah Governorate, Iraq

Alzamily¹,

Al-Delfi²,

Al-Barqaw³

2022

MMSL

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“…Highly correlated processes seen in atherosclerosis include lipid abnormalities, thrombosis, inflammation, activation of vascular smooth cells and platelets, endothelial dysfunction, oxidative stress, and hereditary variables. 19,20 The mean Jabber HN, et al Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes age of control subjects was 54.72±1.405 years, that of diabetes mellitus groups was 56.02±1.395 years and cardiovascular disease and diabetes groups was 59.20±1.478years mellitus and there was no significant difference in mean age among study groups; this result agrees with (21), who found that the mean age of patients with CVD was(55) years. Also, the results came in agreement with a previous study who observed that the mean age of patients with CVD was 64.72 years (55.6-73.8 years).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes

Jabber,

Charfeddine,

Abbas

2024

Pharmacogn J.

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Objective: Comparison of the blood level of TNFα in patients with and without type 2 diabetes who have cardiovascular diseases. Examine the connection between the amount of serum TNFα and insulin resistance in patients with type 2 diabetes who have cardiovascular diseases. Method: The present study included 60 patients with Diabetes Mellitus (DM) with a mean age of 56.02±1.395 years and an age range of (40 -80)years and 60 patients with cardiovascular diseases and diabetes (CVD and DM) with a mean age of 59.20±1.478 and an age range of (40-80) years, Who visited Al-Basrah Teaching Hospital in Basrah. in addition, the study included 60 healthy controls mean age of healthy control subjects was 54.72±1.405years. All patients in this study were diagnosed by specialized doctors and the diagnosis was verified by clinical and laboratory tests, during the period from September 2022 to September 2023. All Subjects signed a written informed consent form. The BMI was calculated as body weight (kg) and was divided by squared height in meters. Results: The results of this study showed an increase in the level of glucose, haemoglobin A1c%, insulin, and HOMA IR (in CVD and DM patients as compared with DM patients and control and there was a significant difference in concentrations among study groups (p-value <0.0001). Also, The results of this study showed an increase in the level of tumor necrosis factor-alpha in CVD and DM patients as compared with DM and control and there was a significant difference in concentrations of TNFα among study groups (p-value <0.0001). Conclusion: Based on the findings of this research, it can be inferred that TNFα and HbA1c have the potential to serve as practical and straightforward indicators for predicting the coexistence of insulin resistance, dysglycemia, and Cardiovascular Diseases in seemingly healthy individuals within the young (<50 years) Al-Basra community.

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Risk factors for severity of coronary artery disease in patients with cardiovascular disease

Cited by 2 publications

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A Role for Inflammatory Il-6 in the Development of Coronary Artery Disease: a Case Control Study at Al-Qadisiyah Governorate, Iraq

A Role for Inflammatory Il-6 in the Development of Coronary Artery Disease: a Case Control Study at Al-Qadisiyah Governorate, Iraq

Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes

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