Risk Factors for Stroke Due to Cerebral Infarction in Young Adults

You, Roger X.; McNeil, John J; O’Malley, Heather M.; Davis, Stephen M.; Thrift, Amanda G; Donnan, Geoffrey A

doi:10.1161/01.str.28.10.1913

Cited by 119 publications

(97 citation statements)

References 46 publications

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“…Young patients differ from other patients with stroke with regards to risk factors, causes, and outcome of stroke. [20][21][22][23][24][25] Therefore, the objectives of our study were to characterize PI and PSI in young patients with first-ever stroke and to explore whether they are associated with worse 3-month outcome and longterm mortality or recurrent vascular events.…”

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confidence: 99%

Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Heikinheimo

Broman

Haapaniemi

et al. 2013

Stroke

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This retrospective study is based on the Helsinki Young Stroke Registry data. The registry includes all consecutive 15-to 49-year-old Background and Purpose-Poststroke infections (PSIs) worsen the outcome in acute ischemic stroke, but the effect of preceding infection (PI) is controversial. Data on young patients are scarce. We characterized PI and PSI in young adults with first-ever stroke and studied whether they are associated with 3-month and long-term outcomes, recurrent vascular events, and death. Methods-From our database of 1008 consecutive patients aged 15 to 49 years, we included in the present study those who had brain imaging done within the first 2 days from stroke onset. Outcomes were unfavorable at 3 months and during long-term follow-up, vascular events, and all-cause death. Logistic regression and Cox proportional models were used to determine associations between infections and clinical outcomes. Results-A total of 681 patients (62.3% men) fulfilled the inclusion criteria. Of these, 70 (10.3%) had PI, most commonly upper respiratory tract infection, and 103 (15.1%) had PSI, most commonly pneumonia. After adjusting for sex, age, and risk factors, both PI (odds ratio, 2.86; 95% confidence interval, 1.48-5.54) and PSI (odds ratio, 2.26; 95% confidence interval, 1.08-4.76) were independently associated with unfavorable 3-month outcome. PSI was also associated with long-term (follow-up, 7.8±4.0 years) higher risk of all-cause death. Conclusions-In young patients with ischemic stroke, both PI and PSIs are associated with unfavorable short-term outcome.PSIs are also associated with higher long-term mortality. (Stroke. 2013;44:3331-3337.)

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confidence: 99%

Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Heikinheimo

Broman

Haapaniemi

et al. 2013

Stroke

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“…This is slightly lower than what the many studies mentioned it (17). CT scan detected white matter changes in 31 patients (30.7%) that were lower than what has been mentioned in many other studies (12,16). These two findings may be as a result of different CT scan protocols or programs used in Iran compared with other radiologic centers.…”

Section: Aq1mentioning

confidence: 57%

“…So the term small deep infarcts are preferred.In a recent study, diffusion-weighted magnetic resonance imaging (DWI) showed multiple regions of increased signal intensity in 16% in either a single (6 patients) or different (4 patients) vascular territories, strongly indicating an embolic stroke mechanism (11). LIs due to cholesterolembolism from the aortic arch have also been described (12). In the Barcelona Stroke Registry, 39(11%) of the 3.577 acute stroke patients had an LI (13).…”

Section: Introductionmentioning

confidence: 93%

Magnetic Resonance Imaging (MRI) findings in patients with brain small vessel disease

Forughipur

Pourrashidi-Boshrabadi

Tafakhori

et al. 2017

IMMINV

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Background: Cerebral small vessel disease (SVD) affects small perforating arteries, causing both lacunar infarction (LI) and confluent white matter lesions (WML). Small vessel disease or lacunar infarct is one of the major stroke subgroups. Lacunar syndromes may be divided into two groups: the classic group (pure motor hemiplegia, pure sensory stroke, ataxic hemiparesis, dysarthria-clumsy hand syndrome, sensorimotor stroke) and the miscellaneous group, including all other lacunar syndromes. We have evaluated risk factors, clinical syndromes, topography, and laboratory findings of 101 consecutive patients with symptomatic lacunar infarcts diagnosed by magnetic resonance imaging. Methods: We analyzed 101 patients with clinical lacunar infarct syndrome who were referred to the neurology department of Qa'em hospital, Mashhad in the northeast of Iran. We assessed clinical features, sex, age, risk factors, radiologic findings and laboratory data of these patients. Results: The pure motor hemiparesis (53.5%) constituted the most usual lacunar syndrome. Mean age of the patients was 63.7± 8.5%. Diabetes mellitus was seen in 14 (13.9%) and hypercholesterolemia in 41 (40.6%) of patients. There were significant differences among ataxic-hemiparesis syndrome and hypertriglyceridemia and CVA history. There was a significant difference between miscellaneous syndromes and valve disease history. Also, there was significant correlation between WML and smoking. Thirty percent of the lesions were detected by CT scan. Conclusion: Sixty percent of the cases were associated with white matter signal changes. Diabetes mellitus were found in 14% of patients. Hypertriglyceridemia, CVA history and valve disease history were associated with some subgroups, but more investigations should be performed for precise assessment of other risk factors.

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“…In the Baltimore-Washington Cooperative Young Stroke Study 19 which compared 296 cases of incident ischemic stroke among black and white adults aged 18-44 years with 1220 community based adults of the same age group, hypertension, diabetes mellitus and current smoking emerged as important risk factors. Similarly, in a comparison of 201 consecutive patients with first onset stroke due to cerebral infarction aged 15-55 years and the same number of matched neighbourhood control subjects conducted as part of the Melbourne Risk Factor Study 20 , hypertension, diabetes mellitus, current smoking, heart disease and long term heavy alcohol consumption were major risk factors. The two case control studies from India that included ischemic stroke in all age groups suggested that hypertension, diabetes mellitus and smoking are important risk factors for stroke in India as they are worldwide 21 .…”

Section: Discussionmentioning

confidence: 99%

Study of Risk Factors and Clinical Profile of Stroke in Young Adults

Jadhav¹,

Bondarde²

2015

MVP J Med Sci

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Background: According to the Global Health Observatory, stroke is the second most common cause of death during last decade with a rising trend. Although stroke is considered to be the disease of older population, with the demographic shift the disease incidence is now shifting to younger age group. This shifting trend to younger age group pose a great concern to the world in terms of days lost to work and mortality. There is paucity of information on stroke in young individuals covering important types of stroke. Aims & Objectives: To study the clinical profile and risk factors associated with the stroke in young adults. Materials & Methods: The present descriptive study was carried out at tertiary care Hospital of Nasik from June 2011 to June 2013. A total of 40 consecutive cases between 15-45 years presenting with stroke were recruited for the study after taking prior informed consent. All cases underwent a detailed history taking, general and clinical examination along with all required Investigations. Data was analysed by SPSS software ver. 17 using appropriate statistical tests. Results: Ischemic stroke was the most common presentation and stroke prevalence was similar across both genders. Headache was the most common symptom followed by vomiting in all types of stroke patients. OC Pills and parity was found to significantly associated with CVST. Obesity, smoking and abnormal lipid profile was found to be significantly associated with thromboemblic stroke. Only 3 out of 40 stroke patients died during the course of study. Conclusion: OC Pills and parity were significantly associated with CVST while obesity, smoking and dyslipidemia were significantly associated with thromboemblic stroke. Outcome in young stroke patients was fairly good.

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Risk Factors for Stroke Due to Cerebral Infarction in Young Adults

Cited by 119 publications

References 46 publications

Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Preceding and Poststroke Infections in Young Adults With First-Ever Ischemic Stroke

Magnetic Resonance Imaging (MRI) findings in patients with brain small vessel disease

Study of Risk Factors and Clinical Profile of Stroke in Young Adults

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