Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid

Neider, Daniel; Lindström, Leif; Bodén, Robert

doi:10.2147/ndt.s107178

Cited by 11 publications

(5 citation statements)

References 16 publications

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“…The presence of a symptoms was labeled as ‘Yes’ (with score 1 or more. The dichotomization of CPRS items had been carried out in previous studies where they were dichotomized into the presence and absence of a symptom [ 32 ]).…”

Section: Methodsmentioning

confidence: 99%

Psychological Health and Digital Social Participation of the Older Adults during the COVID-19 Pandemic in Blekinge, Sweden—An Exploratory Study

Ghazi

Anderberg

Berglund

et al. 2022

IJERPH

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COVID-19 has affected the psychological health of older adults directly and indirectly through recommendations of social distancing and isolation. Using the internet or digital tools to participate in society, one might mitigate the effects of COVID-19 on psychological health. This study explores the social participation of older adults through internet use as a social platform during COVID-19 and its relationship with various psychological health aspects. In this study, we used the survey as a research method, and we collected data through telephonic interviews; and online and paper-based questionnaires. The results showed an association of digital social participation with age and feeling lack of company. Furthermore, in addition, to the increase in internet use in older adults in Sweden during COVID-19, we conclude that digital social participation is essential to maintain psychological health in older adults.

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Section: Methodsmentioning

confidence: 99%

Psychological Health and Digital Social Participation of the Older Adults during the COVID-19 Pandemic in Blekinge, Sweden—An Exploratory Study

Ghazi

Anderberg

Berglund

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…In a cohort study carried out by Neider et al, it was investigated the association between the levels of 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid (CSF), bullying during childhood, and later suicide in patients suffering from schizophrenia. It was observed that bullying during childhood and a low quotient of homovanillic acid/5-hydroxyindoleacetic acid in CSF are associated with later suicide [107]. With regard to in vitro studies on the neuroprotective activity of homovanillic acid, to the best of our knowledge, no findings are currently available.…”

Section: Homovanillic Acidmentioning

confidence: 99%

Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer’s Disease

et al. 2022

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Cognitive impairment, also known as cognitive decline, can occur gradually or suddenly and can be temporary or more permanent. It represents an increasingly important public health problem and can depend on normal aging or be linked to different neurodegenerative disorders, including Alzheimer’s disease (AD). It is now well-established that lifestyle factors including dietary patterns play an important role in healthy aging as well as in the prevention of cognitive decline in later life. Among the natural compounds, dietary polyphenols including phenolic acids have been recently the focus of major attention, with their supplementation being associated with better cognitive status and prevention of cognitive decline. Despite their therapeutic potential, human studies investigating the relation between phenolic acids intake and cognitive outcomes are rather scarce. In this review, we provide preclinical evidence that different dietary polyphenols such as rosmarinic acid, ellagic acid, and cinnamic aldehyde can exert neuroprotective and pro-cognitive activities through different molecular mechanisms including the modulation of pro-oxidant and antioxidant machinery as well as inflammatory status. Future and more numerous in vivo studies are needed to strengthen the promising results obtained at the preclinical level. Despite the excellent pharmacokinetic properties of phenolic acids, which are able to be accumulated in the brain at pharmacologically relevant levels, future studies should also identify which among the different metabolites produced as a consequence of phenolic acids’ consumption may be responsible for the potential neuroprotective effects of this subgroup of polyphenols.

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“…Some studies found lower 5-hydroxy acetic acid (5-HIAAA) levels in the cerebrospinal fluid (CSF) of suicidal patients in comparison to the CSF levels of non-suicidal individuals with schizophrenia [71,74], while other studies did not detect this difference [75,76,77]. One research group found that a blunted prolactin response to a D-fenfluramine administration was associated with suicidal behavior in individuals with a history of schizophrenia [78].…”

Section: Neurobiological Aspects Of Suicidal Behavior In Schizophrmentioning

confidence: 99%

Suicide in Schizophrenia: An Educational Overview

2019

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Suicide is an important public health problem. The most frequent psychiatric illnesses associated with suicide or severe suicide attempt are mood and psychotic disorders. The purpose of this paper is to provide an educational overview of suicidal behavior in individuals with schizophrenia. A lifetime suicide rate in individuals with schizophrenia is approximately 10%. Suicide is the largest contributor to the decreased life expectancy in individuals with schizophrenia. Demographic and psychosocial factors that increase a risk of suicide in individuals with schizophrenia include younger age, being male, being unmarried, living alone, being unemployed, being intelligent, being well-educated, good premorbid adjustment or functioning, having high personal expectations and hopes, having an understanding that life’s expectations and hopes are not likely to be met, having had recent (i.e., within past 3 months) life events, having poor work functioning, and having access to lethal means, such as firearms. Throughout the first decade of their disorder, patients with schizophrenia are at substantially elevated suicide risk, although they continue to be at elevated suicide risk during their lives with times of worsening or improvement. Having awareness of symptoms, especially, awareness of delusions, anhedonia, asociality, and blunted affect, having a negative feeling about, or non-adherence with, treatment are associated with greater suicide risk in patients with schizophrenia. Comorbid depression and a history of suicidal behavior are important contributors to suicide risk in patients with schizophrenia. The only reliable protective factor for suicide in patients with schizophrenia is provision of and compliance with comprehensive treatment. Prevention of suicidal behavior in schizophrenia should include recognizing patients at risk, delivering the best possible therapy for psychotic symptoms, and managing comorbid depression and substance misuse.

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Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid

Cited by 11 publications

References 16 publications

Psychological Health and Digital Social Participation of the Older Adults during the COVID-19 Pandemic in Blekinge, Sweden—An Exploratory Study

Psychological Health and Digital Social Participation of the Older Adults during the COVID-19 Pandemic in Blekinge, Sweden—An Exploratory Study

Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer’s Disease

Suicide in Schizophrenia: An Educational Overview

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