Risk Factors for the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Including Genetics

Lim, Huei-Wen; Bernstein, David

doi:10.1016/j.cld.2017.08.008

Cited by 38 publications

(23 citation statements)

References 134 publications

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“…This can be explained by the rising prevalence of obesity among young women in the United States . Again, our findings are in agreement with previous studies demonstrating higher rates of components of MS in patients with NAFLD …”

Section: Discussionmentioning

confidence: 99%

“…(37) Again, our findings are in agreement with previous studies demonstrating higher rates of components of MS in patients with NAFLD. (6,(38)(39)(40) Racial differences in the prevalence of NAFLD led to some interesting observations. Our data suggest that Mexican American female adults have a higher prevalence of NAFLD than non-Hispanic black and non-Hispanic white female adults.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Nonalcoholic Fatty Liver Disease in the Female Population

et al. 2018

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There is a paucity of recent data about the epidemiology and long‐term outcomes of nonalcoholic fatty liver disease (NAFLD) in the female population. Our aim was to assess the prevalence, risk factors, and mortality of NAFLD in female adults of the United States. Data from the National Health and Nutrition Examination Survey (NHANES) III and NHANES 1999‐2014 were used. NAFLD status was determined by the U.S. Fatty Liver Index (US‐FLI) in the absence of other liver diseases and excessive alcohol consumption. The prevalence rates, risk factors, and 5‐year all‐cause and cardiovascular mortality were determined in women with NAFLD. The most recent prevalence of NAFLD among female adults (2007‐2014) in the United States was 24.4% (95% confidence interval [CI], 22.48‐26.33). Prevalence was higher among women >44 years of age and those with body mass index ≥30 kg/m2. In addition, the average age of the female population with NAFLD has decreased over time. The fully adjusted odds ratios in women with NAFLD compared to those without NAFLD were 1.48 (95% CI, 1.20‐1.82) for cardiovascular disease (CVD), 1.89 (95% CI, 1.42‐2.52) for atherosclerotic cardiovascular disease (ASCVD) score ≥7.5%, and 1.76 (95% CI, 1.37‐2.25) for either CVD or ASCVD ≥7.5%. The 5‐year mortality for female adults with NAFLD was significantly higher than for those without NAFLD (adjusted hazard ratio, 1.48; 95% CI, 1.07‐2.05). Among women with NAFLD, those with ASCVD ≥7.5% had significantly higher 5‐year all‐cause mortality and CVD mortality. Conclusion: The prevalence of NAFLD in female NHANES participants from the United States has continued over recent years. In the female population with NAFLD, ASCVD ≥7.5% is an independent predictor of overall and cardiac‐specific mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of Nonalcoholic Fatty Liver Disease in the Female Population

et al. 2018

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“…Datos adicionales procedentes de Estados Unidos sugieren que la población latinoamericana podría verse desproporcionadamente afectada por la enfermedad. En estos estudios, los sujetos hispanos mostraron sistemáticamente la mayor prevalencia de EHGNA. Es importante señalar que los etnónimos «hispano» y «latino» no se utilizan de manera homogénea en la literatura.…”

Section: ¿Es La Ehgna Más Frecuente O Más Severa En Latinoamérica?unclassified

“…mostraron una presencia diferente de la EHGNA en los subgrupos hispa‐nos/latinos, con una mayor afectación entre los individuos de origen centroamericano, sudamericano y mexicano en comparación con los de origen cubano, portorriqueño y dominicano. Otros estudios han confirmado que la EHGNA es más prevalente entre los hispanos, considerando en este grupo principalmente a los mexicoamericanos (revisión de Lim y Bernstein).…”

Section: ¿Es La Ehgna Más Frecuente O Más Severa En Latinoamérica?unclassified

“…UU. indican que los hispanos tienen un índice de masa corporal más alto que otros grupos étnicos y que los componentes del síndrome metabólico (es decir, obesidad, prediabetes/DM2, hipertensión arterial, obesidad visceral y dislipidemia) son sorprendentemente más elevados en este grupo étnico que en la población caucásica y afroamericana. Se ha señalado que la obesidad central podría ser un factor causal, ya que los hispanos que viven en los Estados Unidos presentan un alto contenido de grasa intraperitoneal y hepática en comparación con los caucásicos y los afroamericanos.…”

Section: Factores Responsables De La Mayor Prevalencia De La Ehgna Enunclassified

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Factores de riesgo de la enfermedad por hígado graso no alcohólico en poblaciones de Latinoamérica: situación actual y perspectivas

Oliveira¹,

Cotrim

Arrese

2019

Clinical Liver Disease

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