Risk factors for the development of pneumonia post cardiac surgery

Topal, Askin Ender; Eren, Mehmet Nesimi

doi:10.5830/cvja-2012-005

Cited by 20 publications

(16 citation statements)

References 16 publications

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“…Many of the identified risk factors for POP following LC surgery are similar to known risk factors for community-acquired pneumonia in general populations [14,22]. Also, a previous study of 162 patients undergoing cardiac surgery showed postoperative atrial fibrillation was a strong risk factor for POP [23]. Consistent with our findings a German questionnaire-based caseecontrol study of 1137 cases with community-acquired pneumonia and 1044 controls found that a history of community-acquired pneumonia increased the risk of a subsequent new pneumonia with an adjusted OR of 1.6 (95% CI: 1.3e2.1) [16].…”

Section: Discussionmentioning

confidence: 66%

Risk factors for postoperative pneumonia after lung cancer surgery and impact of pneumonia on survival

Simonsen

Søgaard

Bozi

et al. 2015

Respiratory Medicine

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Section: Discussionmentioning

confidence: 66%

Risk factors for postoperative pneumonia after lung cancer surgery and impact of pneumonia on survival

Simonsen

Søgaard

Bozi

et al. 2015

Respiratory Medicine

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“…The authors also reported that according to a univariate analysis, the time spent on mechanical ventilation was significantly longer in patients who developed PEP compared to patients who did not. 10 …”

Section: Discussionmentioning

confidence: 99%

“…8-10 The dynamic of extubation seems to play a relevant role in the new onset of PEP. In a multicenter prospective study on mechanically ventilated patients, De Lassence et al, reported that new onset of nosocomial pneumonia is more frequent and happens significantly earlier when extubation is accidental.…”

Section: Introductionmentioning

confidence: 99%

Pathogenic Link Between Postextubation Pneumonia and Ventilator-Associated Pneumonia: An Experimental Study

Rezoagli

Zanella

Cressoni

et al. 2017

Anesthesia &Amp; Analgesia

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Introduction The presence of an endotracheal tube is the main cause for developing ventilator associated pneumonia (VAP), but pneumonia can still develop in hospitalized patients after endotracheal tube removal (Post-Extubation Pneumonia, PEP). We hypothesized that short-term intubation (24h) can play a role in the pathogenesis of PEP. To test such hypothesis, we initially evaluated the occurrence of lung colonization and VAP in sheep that were intubated, and mechanically ventilated for 24h. Subsequently, we assessed the incidence of lung colonization and PEP at 48 h after extubation, in sheep previously ventilated for 24h. Methods To simulate intubated ICU patients placed in semi-recumbent position, fourteen sheep were intubated and mechanically ventilated with the head elevated 30° above horizontal. Seven of them were euthanized after 24h (Control Group) while the remaining were euthanized after been awaken, extubated and left spontaneously breathing for 48h after extubation (Awake Group). Criteria of clinical diagnosis of pneumonia were tested. Microbiological evaluation was performed on autopsy in all sheep. Results Only one sheep in the Control Group met the criteria of VAP after 24h of mechanical ventilation. However, heavy pathogenic bacteria colonization of trachea, bronchi and lungs (range, 104-109 CFU/g) was reported in four out of seven sheep (57%). In the Awake Group, one sheep was diagnosed with VAP and three developed PEP within 48h post extubation (42%), with one euthanized at 30h because of respiratory failure. On autopsy, five sheep (71%) confirmed pathogenic bacterial growth in the lower respiratory tract (range, 103-109 CFU/g). Discussion Twenty-four hours of intubation and mechanical ventilation in semi-recumbent position leads to significant pathogenic colonization of the lower airways, which can promote the development of PEP. Strategies directed to prevent pathogenic microbiological colonization before and after mechanical ventilation should be considered in order to avert the onset of PEP.

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“…3 Pulmonary complications in cardiac transplant recipients remain a major concern since they may cause acute respiratory failure (ARF) associated with significant morbidity and mortality. [2][3][4] Acute respiratory failure in these patients commonly necessitates readmission to the intensive care unit (ICU) during the posttransplant period and adversely affects clinical outcomes. Therefore, this study sought to evaluate cardiac transplant recipients admitted to the ICU to identify the ARF incidence and causes and to assess the risk factors and outcomes of those with ARF.…”

Section: Introductionmentioning

confidence: 99%