Risk factors for the development of hip osteoarthritis: a population-based prospective study

Juhakoski, Riikka; Heliövaara, Markku; Impivaara, Olli; Kröger, Heikki; Knekt, Paul; Laurén, Hanna; Arokoski, Jari

doi:10.1093/rheumatology/ken427

Cited by 104 publications

(89 citation statements)

References 25 publications

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“…However, the reported association of some of these factors with an increased risk of OA or subsequent TJR has not been consistent. Being overweight shows the most consistent association with OA (9,13,15,16) and with TJR (7,8,14), while the results for physical activity and smoking have been the most inconsistent (7,9,(12)(13)(14)(15)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26).…”

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 89%

“…Inconsistencies in the findings of those and other studies reflect sampling biases or nonrepresentative cases, a lack of or incomplete adjustment for comorbidities and other confounders, inconsistencies in definitions of disease, or inaccuracies in definitions of exposure (7,12,16,23). Some studies did not make an appropriate distinction between current and past smoking (16,23), while others disregarded the duration of smoking (7,12).…”

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 97%

“…Independent risk factors for this disorder include older age (12), female sex (13), obesity (13)(14)(15)(16), physical activity (12)(13)(14), and never having smoked (9,13,15). However, the reported association of some of these factors with an increased risk of OA or subsequent TJR has not been consistent.…”

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 99%

“…Smoking has variously shown a negative association with OA (9,13,15,19,20,26) or TJR (21), a positive association with OA (22,23) or TJR (7), and no significant association with OA (12,17,24). Similarly, the association of physical activity with the risk of OA is unclear.…”

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 99%

“…Some studies did not make an appropriate distinction between current and past smoking (16,23), while others disregarded the duration of smoking (7,12).…”

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 99%

See 4 more Smart Citations

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Mnatzaganian¹,

Ryan²,

Norman³

et al. 2011

Arthritis & Rheumatism

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Objective. To assess the associations of smoking, body weight, and physical activity with risk of undergoing total joint replacement (TJR) in a population-based cohort of men.Methods. A cohort study of 11,388 men that integrated clinical data with hospital morbidity data and mortality records was undertaken. The risk of undergoing TJR was modeled on baseline weight, height, comorbidity, socioeconomic status, years of smoking, and exercise in 3 separate age groups, using Cox proportional hazards regressions and competing risk regressions (CRRs).Results. Dose-response relationships between weight and risk of TJR and between smoking and risk of TJR were observed. Being overweight independently increased the risk of TJR, while smoking lowered the risk. The decreased risk among smokers was demonstrated in both Cox and CRR models and became apparent after 23 years of exposure. Men who were in the highest quartile (>48 years of smoking) were 42-51% less likely to undergo TJR than men who had never smoked. Tests for trend in the log hazard ratios (HRs) across both smoking and weight quantiles yielded significant P values. Vigorous exercise increased the hazard of TJR; however, the association reached statistical significance only in the 70-74-year-old age group (adjusted HR 1.64 [95% confidence interval 1.19-2.24]). Adjusting for Deyo-Charlson Index or Elixhauser's comorbidity measures did not eliminate these associations.Conclusion. Our findings indicate that being overweight and reporting vigorous physical activity increase the risk of TJR. This study is the first to demonstrate a strong inverse dose-response relationship between duration of smoking and risk of TJR. More research is needed to better understand the role of smoking in the pathogenesis of osteoarthritis.

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Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 89%

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 97%

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 99%

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 99%

“…Some studies did not make an appropriate distinction between current and past smoking (16,23), while others disregarded the duration of smoking (7,12).…”

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 99%

See 3 more Smart Citations

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Mnatzaganian¹,

Ryan²,

Norman³

et al. 2011

Arthritis & Rheumatism

View full text Add to dashboard Cite

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Do worsening knee radiographs mean greater chances of severe functional limitation?

White¹,

Zhang²,

Niu³

et al. 2010

Arthritis Care & Research

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Management of Osteoarthritis in General Practice in Australia

Brand

Harrison²,

Tropea

et al. 2014

Arthritis Care & Research

131

139

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Results. There were 489,900 GP encounters at which OA was managed (rate of 26.4 per 1,000 encounters). OA-hip was managed at a rate of 2.3 per 1,000 encounters (n ‫؍‬ 1,106, 8.6% OA) and OA-knee at a rate of 6.2 per 1,000 (n ‫؍‬ 3,058, 23.7% OA). The encounter management rate per 1,000 for OA-hip was higher among non-metropolitan dwellers (2.85 per 1,000 versus 1.97 per 1,000) and lower for non-English-speaking people (1.53 per 1,000 encounters versus 2.39 per 1,000). The rate for OA-knee was higher for non-English-speaking background (8.50 per 1,000 encounters versus 6.24 per 1,000) and lower among indigenous people (3.16 per 1,000 encounters versus 6.46 per 1,000). Referral to an orthopedic surgeon was the most frequently used nonpharmacologic management (OA-knee 17.4 per 100 contacts and OA-hip 17.7 per 100), followed by advice, education, and counselling. As first-line treatment, medication prescription rates (OA-knee 78.7 per 100 contacts and OA-hip 73.2 per 100) were substantially higher than rates of lifestyle management (OA-knee 20.7 per 100 contacts and OA-hip 14.8 per 100). Conclusion. OA-hip and OA-knee encounters and management differ. Nonpharmacologic treatments as first-line management were low compared with pharmacologic management rates, and surgical referral rates were high. However, lack of longitudinal data limits definitive assessment of appropriateness of care.

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Risk factors for the development of hip osteoarthritis: a population-based prospective study

Abstract: Heavy physical stress at work and major musculoskeletal injuries are associated with an increased risk of developing clinically diagnosed hip OA.

Cited by 104 publications

References 25 publications

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Do worsening knee radiographs mean greater chances of severe functional limitation?

Management of Osteoarthritis in General Practice in Australia

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