Risk Factors for the Onset of Frozen Shoulder in Middle-Aged and Elderly Subjects Within 1 Year of Discharge From a Hospitalization That Involved Intravenous Infusion: A Prospective Cohort Study

Abstract

AimTo investigate the incidence of frozen shoulder and risk factors for the onset of frozen shoulder in middle-aged and elderly subjects within 1 year of discharge from a hospitalization that involved intravenous infusion in Zhangjiagang Second People's Hospital.MethodsA total of 1,900 subjects who were discharged from a hospitalization that involved intravenous infusion in the hospital between May 2020 and September 2020 met the inclusion criteria for this study: 950 subjects had a mean daily duration of intravenous infusion ≤ 2 h (low exposure) and 950 subjects had a mean daily duration of intravenous infusion ≥3 h (high exposure). Subjects were followed up by telephone at 6 months ± 1 week and 12 months ± 1 week after discharge the incidence of frozen shoulder.ResultsThe cumulative incidence rate of frozen shoulder within 1 year of discharge was 5.2%. Multivariate logistic regression analysis revealed the risk of frozen shoulder was higher in subjects with a mean daily duration of intravenous infusion ≥3 h compared to ≤ 2 h (OR = 3.082, 95% CI 1.919–4.949, P < 0.001); subjects hospitalized for 11–30 days had a higher risk of frozen shoulder compared to those hospitalized for 10 days or less (OR = 6.836, 95%CI 4.363–10.709, P < 0.001); subjects who were overweight/ obese (BMI ≥ 25 kg/m2) had a higher risk of frozen shoulder compared to those of normal weight (BMI 18.5–24.9 kg/m2) (OR = 2.166, 95%CI 1.376–3.410, P = 0.001); subjects in the 56–70-year-old age group had a higher risk of developing frozen shoulder compared to those in the 40–55-year-old age group (OR = 1.977, 95%CI 1.154–3.387, P = 0.013); diabetes increased the risk of frozen shoulder (OR = 3.009, 95%CI 1.826–4.959, P < 0.001). The 71–85 years old age group and hypertension were statistically significant in univariate analysis but not in multivariate analysis (P > 0.05).ConclusionCompared with middle-aged and elderly in the general population, middle-aged and elderly subjects who received intravenous infusion during a hospitalization had a higher cumulative incidence rate of frozen shoulder within 1 year after discharge. Independent risk factors for the onset of frozen shoulder included mean daily duration of intravenous infusion ≥3 h, length of hospital stay 11–30 days, BMI ≥ 25 kg/m2, age 56–70 years, and diabetes.

Prevalence of and Risk Factors for Adhesive Capsulitis of the Shoulder in Older Adults from Germany

“…Given that patients with Parkinson’s disease may have also been followed in neurological practices, one may hypothesize that adhesive capsulitis was documented in neurological and not in general practices, potentially biasing the present association. The relationship between hypertension and adhesive capsulitis remains under debate, as previous studies have reported positive [ 24 ] and null associations [ 8 , 11 , 35 ]. In this context, more data are warranted on the potential hypertension–adhesive capsulitis relationship.…”

A Case Series: Effect of Comorbidities on the Outcomes of Prolotherapy Injection for Frozen Shoulder Patients

“… 23 Univariate analysis of the Cao, 2022 study revealed a strong connection between hypertension and the start of a frozen shoulder (p = 0.009). 24 The mechanism arising from inflammation, with cytokine proliferation leading to an increase in fibroblast proliferation, blood flow increasing in patients with hypertension, and enhanced vascularization, may explain the patient’s pain. 25 In our case, patients with hypertension showed more painful than non-comorbid patients.…”

Risikofaktoren für die Entstehung der primären Schultersteife: ein aktueller Überblick

“…Angiologische Interventionen sind ebenfalls an der Entstehung der Schultersteife beteiligt. Neben der klassischen kardialen Katheterisierung, können intravenöse Infusionen eine Schultersteife begünstigen [1,55]…”

“…Angiological interventions are also implicated in the development of shoulder stiffness. In addition to classic cardiac catheterisation, intravenous infusions can also promote shoulder stiffness [1,55]…”