Risk factors for the progression of Escherichia coli O157:H7 enteritis to hemolytic-uremic syndrome

Cimolai, Nevio; Carter, James E.; Morrison, Brenda J.; Anderson, J. D.

doi:10.1016/s0022-3476(05)81609-9

Cited by 162 publications

(95 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results are consistent with a recent study which found male gender to protect against the progression of E. coli 0 157. H7 colitis to HUS (OR = 0-27; CI 0-083-0852) [20]. Nonetheless, other large studies of sporadic childhood E. coli 0 157.…”

Section: Discussionmentioning

confidence: 99%

Haemolytic anaemia after childhoodEscherichia coliO 157.H7 infection: are females at increased risk?

et al. 1991

View full text Add to dashboard Cite

SUMMARYWe conducted a 4-year retrospective cohort study to better define the risk of haemolytic anaemia and haemolytic uraemic syndrome (HUS) in children following sporadic gastrointestinal infection with the 0 157. H7 serotype of Escherichia coli. Of the 72 children infected with this organism, 9 (12 5 %) developed haemolytic anaemia, 6 of whom had HUS. No child in a cohort of 72 age-matched controls with Campylobacter jejuni gastroenteritis developed haemolytic anaemia (P = 0 003). Females had a significantly greater risk of developing haemolytic anaemia after E. coli 0 157. H7 infection than did males (8/29 females v. 1/43 males; P = 0003). In a logistic regression model, female gender emerged as the only statistically significant risk factor for haemolytic anaemia (odds ratio 3-85; 95% confidence interval 124-12). These results are consistent with recent reports of a moderate increase in the risk of HUS for females.

show abstract

Section: Discussionmentioning

confidence: 99%

Haemolytic anaemia after childhoodEscherichia coliO 157.H7 infection: are females at increased risk?

et al. 1991

View full text Add to dashboard Cite

show abstract

“…Stx-1 is almost identical to Stx from S. dysenteriae type 1, differing by a single amino acid, and is 50% homologous with Stx-2 (44 -46). Despite their similar sequences, Stx-1 and Stx-2 cause different degrees and types of tissue damage as documented by the higher pathogenicity of strains of E. coli that produce only Stx-2 than of those that produce Stx-1 alone (47)(48)(49). In a recent study in children who become infected by Stx-E. coli, E. coli strains that produced Stx-2 were most commonly associated with HUS, whereas most strains that were isolated from children who had diarrhea alone or remained asymptomatic produced only Stx-1 (50).…”

Section: Shiga Toxin or Shiga Toxins?mentioning

confidence: 99%

Hemolytic Uremic Syndrome

Noris¹,

Remuzzi²

2005

Journal of the American Society of Nephrology

502

428

View full text Add to dashboard Cite

“…Nonetheless, sub-inhibitory levels that target DNA synthesis (ciprofloxacin/TMP-SMX) increase STX production; whilst ciprofloxacin's complete suppression of O157:H7 markedly increases levels of STX. Antibiotics targeting cell wall, 20 Prospective cohort 292 0.12 (0.02---0.75) Cimolai et al 21 Retrospective case---control 128 0.63 (0.27---1.43) Dundas et al 32 Retrospective cohort 120 1.23 (0.4---3.8) Martin et al 26 Retrospective cohort 117 9.4 (1.2---199) Higami et al 27 Retrospective control 216 NS d Shiomi et al 28 Retrospective 22 Prospective cohort 10 14.25 (3.62---56.1) h Pavia et al 23 Retrospective case---control 23 NS i Slutsker et al 29 Retrospective case---control 93 11.5 (1.4---91.8) j Ostroff et al 31 Retrospective case---control 80 3.1 (0.6---9.8) k 9.1 (NS) l Carter et al 30 Retrospective transcription and translation do not have any effect on STX levels. Based on the evidence, during this outbreak Germany's infectious diseases society recommended to avoid the use of FQ, TMP-SMX, aminoglycosides and fosfomycin in EHEC patients.…”

Section: Managementmentioning

confidence: 99%

E. coli O104:H4 outbreak and haemolytic–uraemic syndrome

Borgatta

Kmet-Lunaček

Rello

2012

Medicina Intensiva (English Edition)

View full text Add to dashboard Cite

Background: The first cases of the European epidemic of Shiga toxin-producing Escherichia coli O104:H4 (STEC-O104:H4) infection were reported in Germany in April 2011. Objectives: To characterize the 2011 STEC-O104:H4 outbreak and its management. A literature review is made to assess the state of the art in STEC---haemolytic---uraemic syndrome (HUS) epidemiology, pathogenesis, management and prognosis, focusing on critically ill adults. Methods: References were obtained from the European Center for Disease Control and World Health Organization epidemiological updates, in addition to a PubMed search covering the period from 1980 to August 2011, including all published work on STEC-014:H4 and reviews on HUS management and prognosis. Results: The epidemic originated from a bean and seed sprouts farm in Lower Saxony, and was caused by the O104:H4 strain ---a highly antibiotic resistant, hybrid enteroaggregative ---Shiga toxin producing E. coli strain (STEC). The infection was characterized by increased HUS (25%) and a higher mortality rate. STEC enteritis and HUS are associated with significant mortality and morbidity, especially amongst patients with severe renal and neurological disorders. Management should center on prompt kidney protection by maintaining adequate renal perfusion, in addition to avoiding diuretics and nephrotoxic agents. Conclusions:The published studies regarding antibiotic treatment lack good quality evidence. However, recent data suggest a potential modulating effect that explains the conflicting data but moreover suggests that azithromycin might be of use. Neutralizing monoclonal antibodies are a promising new therapy for STEC---HUS, with currently ongoing studies. Other treatments have not been shown to be superior to supportive therapy alone. E. coli O104:H4 outbreak and haemolytic---uraemic syndrome 577 PALABRAS CLAVEE. coli O104:H4; STEC-O104; Revisión; Síndrome urémico-hemolítico Brote de E. coli O104:H4 y síndrome hemolítico-urémico ResumenAntecedentes: Los primeros casos de la epidemia europea de infección por E. coli productora de la toxina Shiga (STEC-O104:H4) se detectaron en Alemania en abril de 2011. Objetivos: Caracterizar el brote de STEC-O104:H4 de 2011 y su gestión. Se realiza una revisión bibliográfica para evaluar el estado del arte en epidemiología, patogenia, tratamiento y pronósitico de la STEC-síndrome urémico-hemolítico (SHU), con especial hincapié en los adultos críticamente enfermos. Métodos: Se obtuvieron referencias de las actualizaciones epidemiológicas del Centro Europeo de Control de Enfermedades y de la Organización Mundial de la Salud, además de una búsqueda en PubMed relativa al periodo de 1980 a agosto de 2011, incluidas todas las publicaciones sobre la STEC-014:H4 y las revisiones sobre el tratamiento y el pronóstico del SHU. Resultados: La epidemia tuvo su origen en unos brotes germinados de una plantación de Baja Sajonia y estuvo causada por la cepa O104:H4, una cepa híbrida de E. coli enteroagregativa productora de la toxina Shiga (STEC) con una e...

show abstract

Risk factors for the progression of Escherichia coli O157:H7 enteritis to hemolytic-uremic syndrome

Cited by 162 publications

References 13 publications

Haemolytic anaemia after childhoodEscherichia coliO 157.H7 infection: are females at increased risk?

Haemolytic anaemia after childhoodEscherichia coliO 157.H7 infection: are females at increased risk?

Hemolytic Uremic Syndrome

E. coli O104:H4 outbreak and haemolytic–uraemic syndrome

Contact Info

Product

Resources

About