Risk factors for the progression of carotid intima-media thickness over a 16-year follow-up period: The Malmö Diet and Cancer Study

Rosvall, Maria; Persson, Margaretha; Östling, Gerd; Nilsson, Peter M.; Melander, Olle; Hedblad, Bo; Engström, Gunnar

doi:10.1016/j.atherosclerosis.2015.01.030

Cited by 125 publications

(140 citation statements)

References 44 publications

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“…We found a positive correlation between the presence of atherosclerosis and cIMT and fIMT measurements in CKD patients, suggesting that IMT values could be used to predict the presence or absence of vascular atherosclerotic disease. This is particularly observed after controlling for age, as prior studies have demonstrated that cIMT increases approximately 0.01 mm per year in both men and women [21, 22]. However, we were unable to demonstrate that IMT values could be used to predict the severity of atherosclerosis in CKD patients.…”

Section: Discussioncontrasting

confidence: 72%

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

Nezami

Ghabili

Shokouhi-Gogani

et al. 2018

Nephron

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Background/Aims: Variability in the grade of atherosclerosis among patients with chronic kidney disease (CKD) could affect the ultrasound measurements of intima media thickness (IMT). We sought to investigate IMTs of carotid (cIMT) and femoral (fIMT) arteries in CKD patients and assess the degree of their correlation with histopathological atherosclerosis. Methods: Eighty-nine out of 99 enrolled subjects completed this study. The subjects were divided into 3 groups: 34 patients with CKD (Case group), 31 with coronary artery disease undergoing coronary artery bypass graft (CABG, positive control group), and 24 healthy kidney donors (negative control group). For histopathological assessment of atherosclerosis, arterial tissue samples were obtained from the patients in each study group. The cIMT and fIMTs were measured by ultrasonography. Results: Histopathological atherosclerosis was present in 82.3, 100, and 20.8% of CKD, CABG, and donor groups respectively (p < 0.001). CKD patients had higher values of cIMT and fIMT than the donor group (p = 0.01 and 0.004, respectively). cIMT was positively correlated with the grade of atherosclerosis in the CKD group only (p < 0.001), while fIMT was correlated with the grade of atherosclerosis in both CKD and donor groups (p < 0.001 and p = 0.009 respectively). In CKD patients, cIMT >0.65 mm and femoral values >0.57 mm predicted the presence of histopathological atherosclerosis with sensitivities of 96 and 92% respectively. Conclusion: Higher values of cIMT and fIMT in CKD patients are associated with higher rates and degrees of histopathological atherosclerosis. Additionally, when compared to fIMT, cIMT has a higher sensitivity for detecting atherosclerosis in CKD patients.

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Section: Discussioncontrasting

confidence: 72%

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

Nezami

Ghabili

Shokouhi-Gogani

et al. 2018

Nephron

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“…From this cohort, a random sample of 6,103 individuals screened between 1991 and 1994 were selected to participate in a study aimed at studying cardiovascular risk factors, the MDC Cardiovascular Cohort (MDC-CC). All individuals from the MDC-CC were invited to participate in a reinvestigation starting in 2007 (49). Of 6,103 individuals, 3,734 (age 61-85 years) accepted and were reexamined between May 2007 and January 2012 and are included in this study.…”

Section: Methodsmentioning

confidence: 99%

Genetic determinants of circulating GIP and GLP-1 concentrations

Almgren¹,

Lindqvist²,

Krus³

et al. 2017

JCI Insight

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“…Following these exclusions, 4800 participants remained, constituting the sample in the present study. Individuals in the Malmö Diet and Cancer cardiovascular subcohort were invited during 2007 and 2012 (after a mean of 16 y of follow-up) to participate in a re-examination including anthropometric measurements (13). Of the 4800 participants, 3054 also had information on weight at the re-examination (Supplemental Figure 1).…”

Section: Study Populationmentioning

confidence: 99%

Dietary starch intake modifies the relation between copy number variation in the salivary amylase gene and BMI

Rukh

Ericson

Andersson‐Assarsson

et al. 2017

The American Journal of Clinical Nutrition

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Background: Studies have shown conflicting associations between the salivary amylase gene (AMY1) copy number and obesity. Salivary amylase initiates starch digestion in the oral cavity; starch is a major source of energy in the diet. Objective: We investigated the association between AMY1 copy number and obesity traits, and the effect of the interaction between AMY1 copy number and starch intake on these obesity traits. Design: We first assessed the association between AMY1 copy number (genotyped by digital droplet polymerase chain reaction) and obesity traits in 4800 individuals without diabetes (mean age: 57 y; 60% female) from the Malmö Diet and Cancer Cohort. Then we analyzed interactions between AMY1 copy number and energyadjusted starch intake (obtained by a modified diet history method) on body mass index (BMI) and body fat percentage. Results: AMY1 copy number was not associated with BMI (P = 0.80) or body fat percentage (P = 0.38). We observed a significant effect of the interaction between AMY1 copy number and starch intake on BMI (P-interaction = 0.007) and body fat percentage (P-interaction = 0.03). Upon stratification by dietary starch intake, BMI tended to decrease with increasing AMY1 copy numbers in the low-starch intake group (P = 0.07) and tended to increase with increasing AMY1 copy numbers in the high-starch intake group (P = 0.08). The lowest mean BMI was observed in the group of participants with a low AMY1 copy number and a high dietary intake of starch. Conclusions: Our findings suggest an effect of the interaction between starch intake and AMY1 copy number on obesity. Individuals with high starch intake but low genetic capacity to digest starch had the lowest BMI, potentially because larger amounts of undigested starch are transported through the gastrointestinal tract, contributing to fewer calories extracted from ingested starch.Am J Clin Nutr 2017;106:256-62.

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Risk factors for the progression of carotid intima-media thickness over a 16-year follow-up period: The Malmö Diet and Cancer Study

Abstract: There were differences in the associations between risk factors and progression rate in different arterial segments. Favourable changes in SBP and lipids during the follow-up period were associated with reduced IMT progression rates in the CCA.

Cited by 125 publications

References 44 publications

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

Genetic determinants of circulating GIP and GLP-1 concentrations

Dietary starch intake modifies the relation between copy number variation in the salivary amylase gene and BMI

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