Risk Factors for the Treatment Failure of Antibiotic-Loaded Cement Spacer Insertion in Diabetic Foot Infection

Treatment of Foot and Ankle Infection with Antibiotic Cement Spacer

“…But the use of intravenous antibiotics should not be stopped because residual infection may remain or suboptimal antibiotic sensitivity may exist [5]. In this study, systemic antibiotics were additionally used in all cases but the duration of the antibiotic administration was 2 weeks less than 6 weeks on average in bone infection [1,2]. The authors believed that the use of antibiotic cement spacer in combination with systemic antibiotics may shorten the treatment period for foot and ankle bone infection.…”

“…Antibiotic cement spacers have been used in various aspects of orthopedic fields including bone infection and open fracture [1][2][3]. Surgical excision and debridement of non-viable and infected soft tissue and bone followed by antibiotic cement spacer placement were performed to alleviate bone infection [2,4].…”

“…There are some literatures concerning the treatment using antibiotic cement spacer in foot and ankle infection [1][2][3][4][5][6]. But there are only few literatures with respect to the appropriate time of removing the cement spacer and complications that occur without its removal.…”

“…Infection, Foot and ankle, Antibiotic cement spacer acute or chronic osteomyelitis [4]. With respect to the foot and ankle infection, an antibiotic cement spacer plays an important role of alleviating infections by prevention soft tissue contracture or bone shortening and avoiding amputation [1,2,4,5].…”

Clinical Efficacy of Antibiotic Bone Cement and Lateral Bone Repositioning for Severe Diabetic Foot and its Impact on Wound Healing Rate

“…Compared with intravenous or oral antibiotics, antibiotic bone cement releases a significantly higher concentration of antibiotics, longer duration of action, has more significant local bactericidal ability and prevents the development of drug-resistant bacteria, thereby creating a good antibacterial environment, contributing to the control of traumatic infections and reducing the adverse effects produced by prolonged systemic administration [26] . The antibiotic bone cement provides close apposition to the ulcerated wound, removes the ineffective cavity, enhances the antibiotic efficacy and creates a better environment for wound healing, with easy operation, short operation time and lower difficulty of second stage wound closure [27] . This study has the following limitations; the sample size of this study was small and only a single-center trial was conducted, which is subject to selective bias; it was not possible to evaluate the test results blindly during the study, which was subject to measurement bias and longterm efficacy evaluation was absent.…”