Risk factors for types of recurrent tuberculosis (reactivation versus reinfection): A global systematic review and meta-analysis

Qiu, Beibei; Wu, Zhuchao; Tao, Bilin; Li, Zhongqi; Song, Huan; Tian, Dan; Wu, Jizhou; Zhan, Mengyao; Wang, Jianming

doi:10.1016/j.ijid.2021.12.344

Cited by 33 publications

(28 citation statements)

References 45 publications

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“…Several factors can influence the reactivation of TB in patients. These factors include immunosuppression and myelosuppression resulting from anti‐TNF‐α drugs, leading to B‐cell downstream activation and T‐cell depletion 9,10 . Considering the mechanism of action of PV, anti‐CD79b activity can lead to B‐cell depletion, which in turn leads to a cascade of downstream mechanisms such as altered cytokine release, leukocyte infiltration, and decreased T‐cell activity 11 .…”

Section: Discussionmentioning

confidence: 99%

Disseminated tuberculosis after Polatuzumab‐Vedotin based chemoimmunotherapy in a patient with Burkitt's lymphoma

Elkourashy,

Benkhadra,

Shafei

et al. 2024

Clinical Case Reports

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Key Clinical MessageThis report highlights the risk of latent tuberculosis (TB) reactivation after treatment with Polatuzumab Vedotin (PV), Rituximab, and Bendamustine (PBR protocol) despite appropriate chemoprophylaxis. A 48‐year‐old male with refractory Burkitt's lymphoma (BKL) was treated with PBR protocol. At baseline, the patient had a negative QuantiFERON test result, which turned out to be positive prior to starting PBR. He received chemoprophylaxis for 9 months and was compliant with treatment. One year later, he was admitted with COVID‐19 pneumonia and was treated according to the protocol. His symptoms persisted for 1 month. Investigations yielded disseminated TB‐infiltrated bone marrow and pleura. Downstream B‐cell and T‐cell depletion secondary to CD20 and CD79b antagonism may potentially explain the increased risk of TB reactivation associated with the combination of PV and rituximab. Further research is necessary to monitor the risk of TB reactivation among patients receiving a combination of PV and rituximab, especially in endemic areas with high prevalence and incidence of TB.

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Section: Discussionmentioning

confidence: 99%

Disseminated tuberculosis after Polatuzumab‐Vedotin based chemoimmunotherapy in a patient with Burkitt's lymphoma

Elkourashy,

Benkhadra,

Shafei

et al. 2024

Clinical Case Reports

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“…This may be a microbiological factor that contributes to the high ranking of TB incidence in the Republic of Korea compared with other OECD countries. 25 , 28 …”

Section: Discussionmentioning

confidence: 99%

A comparison of phenotypic and WGS drug susceptibility testing in Mycobacterium tuberculosis isolates from the Republic of Korea

Lee

Ferran

Witney

et al. 2023

JAC-Antimicrobial Resistance

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Background WGS has significant potential to help tackle the major public health problem of TB. The Republic of Korea has the third highest rates of TB of all Organisation for Economic Cooperation and Development countries but there has been very limited use of WGS in TB to date. Objectives A retrospective comparison of Mycobacterium tuberculosis (MTB) clinical isolates from 2015 to 2017 from two centres in the Republic of Korea using WGS to compare phenotypic drug susceptibility testing (pDST) and WGS drug susceptibility predictions (WGS-DSP). Methods Fifty-seven MTB isolates had DNA extracted and were sequenced using the Illumina HiSeq platform. The WGS analysis was performed using bwa mem, bcftools and IQ-Tree; resistance markers were identified using TB profiler. Phenotypic susceptibilities were carried out at the Supranational TB reference laboratory (Korean Institute of Tuberculosis). Results For first-line antituberculous drugs concordance for rifampicin, isoniazid, pyrazinamide and ethambutol was 98.25%, 92.98%, 87.72% and 85.96%, respectively. The sensitivity of WGS-DSP compared with pDST for rifampicin, isoniazid, pyrazinamide and ethambutol was 97.30%, 92.11%, 78.95% and 95.65%, respectively. The specificity for these first-line antituberculous drugs was 100%, 94.74%, 92.11% and 79.41%, respectively. The sensitivity and specificity for second-line drugs ranged from 66.67% to 100%, and from 82.98% to 100%, respectively. Conclusions This study confirms the potential role for WGS in drug susceptibility prediction, which would reduce turnaround times. However, further larger studies are needed to ensure current databases of drug resistance mutations are reflective of the TB present in the Republic of Korea.

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“…Tuberkulosis merupakan penyakit menular yang paling mematikan di dunia yang diakibatkan agen bakteri Mycobacterium tuberculosis (Cadena et al, 2017) (Simmons et al, 2018). Penyakit ini merupakan salah satu dari sepuluh penyebab kematian terbesar di dunia (Qiu et al, 2022). Meskipun ada perlindungan menggunakan vaksin Bacillus Calmette-Guérin (BCG), namun upaya pemberian vaksin BCG memberikan efek kemanjuran yang bervariasi terhadap perlindungan dari penularan Tuberkulosis (Ravimohan et al, 2018).…”

Section: A Latar Belakangunclassified

Deteksi Dini Tuberkulosis Paru Melalui Pemeriksaan Anti-Tb Kepada Masyarakat

Meri

Nurpalah

Kusmiati

et al. 2022

JMM

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Abstrak : Peningkatan kasus baru Tuberkulosis dapat karena adanya individu kontak erat dengan penderita Tuberculosis, yang dapat meningkat sebanyak 6,6 kali lipat. Mengingat hal tersebut diperlukan adanya upaya preventif agar tidak terjadi kasus baru melalui penegakkan diagnosa secara dini sehingga dapat diketahui apakah individu ada yang sudah terpapar atau belum, selain itu dapat dilakukan upaya-upaya pencegahan seperti yang dicanangkan dalam laporan Tuberculosis secara global oleh WHO. Wilayah kerja Puskesmas Mangkubumi merupakan wilayah yang memiliki kasus Tuberkulosis, sehingga diperlukan upaya pengendalian kasus. Tujuan pengabdian masyarakat adalah untuk mendeteksi dini kasus Tuberculosis menggunakan diagnosa laboratorium Anti-TB sebagai upaya preventif dan bahkan pengobatan lebih lanjut jika ada yang terpapar. Metode yang dilakukan adalah melalui pemeriksaan laboratorium Rapid Tes Anti-TB ke rumah masing-masing warga yang dekat dengan penderita Tuberculosis. Hasil pengabdian yaitu sebanyak 5 orang yang bersedia diperiksa hasilnya adalah negative. Evaluasi kegiatan dilakukan melalui jumlah persentase antusias masyarakat dalam melakukan deteksi dini kasus Tuberkulosis. Keseimpulan: masyarakat terdeteksi secara dini tidak mengalami tuberkulosis. Masyarakat disarankan untuk lebih intensif memeriksakan diri ke pelayanan kesehatan terutama masyarakat yang diduga masih memiliki kontak erat dengan penderita serta mengkonsumsi makanan yang kayak nutrisi.Abstract: The increase in new cases of tuberculosis can be caused by the presence of individuals who are in close contact with people with tuberculosis, which can increase by as much as 6.6 times. As a consequence, preventive measures should be implemented to avoid the occurrence of new cases through the use of diagnostic testing, allowing it to be determined whether any individual suffers or not. Also, preventive steps should be taken to find out if the person gets sick or not. The purpose of community service is to early detect tuberculosis cases using anti-TB laboratory diagnostics as a preventive effort and even further treatment if anyone is exposed. The method carried out is through a Rapid Anti-TB Test laboratory examination of the homes of each resident who is close to tuberculosis sufferers. The result of the service is that as many as five people who are willing to be checked, the results are negative. Evaluation of activities is carried out through the percentage of community enthusiasm in conducting early detection of tuberculosis cases. People who check for anti-TB do not experience tuberculosis. People are advised to more intensively check themselves into health services, especially people who are suspected of still having close contact with sufferers. People are advised to more intensively check themselves into health services, especially people who are suspected of still having close contact with sufferers and consuming foods that are high in nutrients.

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Risk factors for types of recurrent tuberculosis (reactivation versus reinfection): A global systematic review and meta-analysis

Cited by 33 publications

References 45 publications

Disseminated tuberculosis after Polatuzumab‐Vedotin based chemoimmunotherapy in a patient with Burkitt's lymphoma

Disseminated tuberculosis after Polatuzumab‐Vedotin based chemoimmunotherapy in a patient with Burkitt's lymphoma

A comparison of phenotypic and WGS drug susceptibility testing in Mycobacterium tuberculosis isolates from the Republic of Korea

Deteksi Dini Tuberkulosis Paru Melalui Pemeriksaan Anti-Tb Kepada Masyarakat

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