1994
DOI: 10.1111/j.1398-9995.1994.tb00831.x
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Risk factors in early childhood for the development of atopic diseases

Abstract: Risk factors in early childhood for the development of atopic diseasesBjOrksten B. Risk factors in early childhood for the development of atopic diseases. Allergy 1994: 49: 400-407.

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Cited by 186 publications
(109 citation statements)
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“…However, chronic FA exposure in occupational settings over many years may lead to lung-function impairment, as recently shown by Kilburn et al (19), whereas, in earlier studies, an association between chronic occupational FA exposure and respiratory symptoms could not be demonstrated (20,21). Air pollution has been previously shown to be associated with allergic sensitization in epidemiologic studies (6). Furthermore, in animal experiments, exposure to sulfur dioxide and ozone significantly enhanced allergic sensitization to inhaled allergens (7)(8)(9), and environmental tobacco smoke, which contains FA in higher concentrations, has been shown to increase the sensitization rate in children (22,23) and in experimental animal studies (21).…”
Section: Discussionmentioning
confidence: 87%
“…However, chronic FA exposure in occupational settings over many years may lead to lung-function impairment, as recently shown by Kilburn et al (19), whereas, in earlier studies, an association between chronic occupational FA exposure and respiratory symptoms could not be demonstrated (20,21). Air pollution has been previously shown to be associated with allergic sensitization in epidemiologic studies (6). Furthermore, in animal experiments, exposure to sulfur dioxide and ozone significantly enhanced allergic sensitization to inhaled allergens (7)(8)(9), and environmental tobacco smoke, which contains FA in higher concentrations, has been shown to increase the sensitization rate in children (22,23) and in experimental animal studies (21).…”
Section: Discussionmentioning
confidence: 87%
“…On the contrary when correlations were made between autoimmune diseases and infections, the incidences were found to be increased in the subjects who are at reduced risk of infections. The same holds true as autoimmune diseases have a rampant growth in western countries where the infectious incidences are lower compared to less developed nations (Bach, 2002;Patterson et al, 1996) substantiating the concept of hygiene hypothesis which states that the microbial exposure enhances the body's defence mechanisms ( Bjorksten B, 1994).…”
Section: Role Of Infectionsmentioning
confidence: 84%
“…En vesentlig grunn til denne interesse har vaert den høye (1-6) og økende (7)(8)(9)(10) forekomsten av disse sykdommene. Arv har stor betydning for utviklingen av disse sykdommene (11,12), men undersøkelser har også rapportert at sykdommene er assosiert med svangerskapsrelaterte forhold og eksponeringer tidlig i livet (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Blant annet har det vaert vist at fødselsvekt, gestasjonsalder, mors alder, paritet og hodeomkrets ved fødsel er assosiert med en eller flere atopirelaterte tilstander (12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”
Section: Introduksjonunclassified
“…Dette har vaert tolket som at disse assosiasjonene kan utrykke påvirkning av fosterets immunsystemutvikling. Videre har det vaert foreslått at visse typer infeksjoner i svangerskap og i tidlig liv kan på-virke utvikling av disse sykdommene (15)(16)(17)(18)21,22,26,27). En finsk undersøkelse fant sammenhenger mellom mors infeksjoner i svangerskapet og astma blant barna i 7-års alderen (22).…”
Section: Introduksjonunclassified