Risk factors in multiple sclerosis: a population-based case-control study in Hautes-Pyrénées, France

Berr, Claudine; Puel, J; Clanet, M.; Ruidavets, Jean‐Bernard; Mas, Jean Louis; Alpérovitch, Annick

doi:10.1111/j.1600-0404.1989.tb03841.x

Cited by 80 publications

(92 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Population-based epidemiological studies suggested an association between the incidence of MS and the intake of saturated fat of animal origin; however findings were not confirmed by the majority of the case-control studies (7)(8)(9)(10)(11).…”

Section: Diet As a Cause Of Msmentioning

confidence: 89%

See 1 more Smart Citation

Nutrition in multiple sclerosis

Habek

Hojsak

Brinar

2010

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

Section: Diet As a Cause Of Msmentioning

confidence: 89%

“…A large number of different diet compounds were also associated with MS (3), sweets (7), alcohol (9,12), smoked meat products (12), coffee and tea (10). However, none of the data were confirmed with subsequent studies.…”

Section: Diet As a Cause Of Msmentioning

confidence: 99%

Nutrition in multiple sclerosis

Habek

Hojsak

Brinar

2010

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

“…25,26 Still, other studies, however, reported no significant association of tonsillectomy with multiple sclerosis or rheumatoid arthritis. [26][27][28] Finally, the significantly higher rates of history of UTI, vaginal infection, and shingles among cases compared with siblings and friends (along with a higher rate of tonsillectomy, mentioned above), suggest the possible involvement of infectious agents in the etiology of PBC. It should be mentioned that no laboratory confirmation of UTI was made; the question was phrased "Has a doctor ever told you that you had a urinary tract infection?"…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Primary Biliary Cirrhosis in A Cohort of Patients From the United States

et al. 2001

View full text Add to dashboard Cite

Primary biliary cirrhosis (PBC) is an uncommon and enigmatic autoimmune disease, characterized by female predominance, autoantibodies to mitochondrial antigens (AMA), destruction of small bile ducts, and ultimately cirrhosis and liver failure. 1,2 Although genetic factors appear to be important in determining susceptibility to autoimmune diseases such as PBC, studies of a variety of autoimmune diseases in monozygotic twins have revealed concordance rates of only 10% to 50%. 1,2 Thus, environmental factors may trigger disease in susceptible individuals. Among the factors that have been suggested to play a role in the etiology of PBC are infectious diseases, 3 other autoimmune diseases, 4 and lifestyle factors, such as smoking, 5 and a high-fat diet. 6,7 Although many mechanisms have been proposed 3,7-9 by which these various factors may be involved in PBC, little epidemiologic research in the United States has been conducted; most published research consists of case reports and laboratory studies. The lack of conclusive information about the etiology of PBC is due, in part, to the methodologic difficulties of studying the disease and also to its relative rarity. Previous studies have been hindered by small sample sizes, unrepresentative samples, lack of a standard case definition, and lack of inclusion of appropriate comparison groups. 10 This report is unique because of its size and its use of two sets of controls, including siblings. PATIENTS AND METHODSStudy Population. A total of 241 patients with PBC were identified from an electronic mail list server for an Internet support group for individuals with PBC. All people on the electronic mail list server were sent a questionnaire. Confirmation of the diagnosis of PBC was performed as described later. PBC cases who completed the survey were asked to provide names and addresses of their siblings to serve as a comparison group. The cases were later asked to provide the names and addresses of 3 friends who were the same sex, within 5 years of their age, and who did not have PBC to serve as a second comparison group. Siblings were sent the same packet of information as cases (see below), whereas friends were sent an abbreviated questionnaire, omitting the dietary questions. A total of 241 individuals with PBC, 261 siblings, and 225 friends were identified.Data Collection. The questionnaire for the study was developed using standardized questions drawn from the National Health and Nutrition Examination Survey (NHANES). 11 These questions have been tested for reliability and validity in a number of studies. 12 The initial survey instrument was pilot tested in approximately 25 individuals without PBC, after which appropriate modifications were made. The final survey included 209 questions, with many of them having several parts, for a total of 983 variables. The survey instrument included questions about demographics (age, education, gender, race/ethnicity), general medical history (including childhood illnesses, infectious illnesses, chronic diseases, surgeries, and m...

show abstract

“…In addition to a genetic predisposition (Ebers and Sadovnick 1994), epidemiological studies suggest a strong association between increased MS prevalence and particular diets (Antonovsky et al 1965;Cendrowski et al 1969;Berr et al 1989;Tola et al 1994). Studies conducted on dietary factors associated with MS have included fat consumption, particularly saturated animal fat (Payne 2001); breastfeeding duration (Isaacs et al 2010); and the intake of sweets (Antonovsky et al 1965), alcohol (Berr et al 1989;Sepcic et al 1993), smoked meat products (Sepcic et al 1993), coffee, and tea (Tola et al 1994). However, Agranoff and Goldberg (1974) implicate foods rich in both omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) in negative correlations with MS-omega-3 PUFAs are derived from fish oils, whereas omega-6 PUFAs are obtained from plants such as sunflower, corn, wheat germ, and soybean oils.…”

Section: Demyelination/remyelination and Nutrientsmentioning

confidence: 99%

Nutritional factors and aging in demyelinating diseases

Adamo

2013

Genes Nutr

View full text Add to dashboard Cite

Demyelination is a pathological process characterized by the loss of myelin around axons. In the central nervous system, oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Remyelination is a regenerative process by which myelin sheaths are restored to demyelinated axons, resolving functional deficits. This process is often deficient in demyelinating diseases such as multiple sclerosis (MS), and the reasons for the failure of repair mechanisms remain unclear. The characterization of these mechanisms and the factors involved in the proliferation, recruitment, and differentiation of oligodendroglial progenitor cells is key in designing strategies to improve remyelination in demyelinating disorders. First, a very dynamic combination of different molecules such as growth factors, cytokines, chemokines, and different signaling pathways is tightly regulated during the remyelination process. Second, factors unrelated to this pathology, i.e., age and genetic background, may impact disease progression either positively or negatively, and in particular, age-related remyelination failure has been proven to involve oligodendroglial cells aging and their intrinsic capacities among other factors. Third, nutrients may either help or hinder disease progression. Experimental evidence supports the anti-inflammatory role of omega-6 and omega-3 polyunsaturated fatty acids through the competitive inhibition of arachidonic acid, whose metabolites participate in inflammation, and the reduction in T cell proliferation. In turn, vitamin D intake and synthesis have been associated with lower MS incidence levels, while vitamin D-gene interactions might be involved in the pathogenesis of MS. Finally, dietary polyphenols have been reported to mitigate demyelination by modulating the immune response.

show abstract

Risk factors in multiple sclerosis: a population-based case-control study in Hautes-Pyrénées, France

Cited by 80 publications

References 28 publications

Nutrition in multiple sclerosis

Nutrition in multiple sclerosis

Risk Factors for Primary Biliary Cirrhosis in A Cohort of Patients From the United States

Nutritional factors and aging in demyelinating diseases

Contact Info

Product

Resources

About