Risk factors, incidence, and prevalence of diabetes among rural farm and non-farm residents of Saskatchewan, Canada; a population-based longitudinal cohort study

Alam, Sheikh Shamimul; Dyck, Roland; Janzen, Bonnie; Karunanayake, Chandima; Dosman, James A.; Pahwa, Punam

doi:10.1007/s40200-020-00693-z

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Confounding covariates included age (continuous) [ 2 ], sex (male or female) [ 10 ], ethnicity (non-Hispanic white, non-Hispanic black, Mexican-American, or other) [ 11 ], obesity (underweight, normal, overweight, obese, or unknown) [ 3 , 12 ], education (< high school, high school, or > high school) [ 2 ], poverty-income ratio (< 130, 130–349%, ≥ 350%, or unknown) [ 10 , 13 ], and survey periods (1988–1991, 1991–1994, 1999–2000, 2001–2002, 2003–2004, 2005–2006, 2007–2008, 2009–2010, 2011–2012, or 2013–2014). NHANES III was conducted in two stages, i.e., from 1988 to 1991 and then from 1991 to 1994, and the subsequent cycles of NHANES were conducted once every 2 years.…”

Section: Methodsmentioning

confidence: 99%

Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults

Wang

2021

Lipids Health Dis

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Background It is unknown whether higher triglyceride results in higher mortality from diabetes, i.e., diabetes mortality. This study aimed to investigate the association of fasting triglyceride with diabetes mortality. Methods This study included 26,582 US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. Diabetes mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglyceride for diabetes mortality. Results Higher levels of fasting triglyceride were associated with higher levels of glucose, glycated hemoglobin, insulin, and homeostatic model assessment for insulin resistance at baseline. A 1-natural-log-unit increase in triglyceride (e.g., from 70 to 190 mg/dL) was associated with a 115% higher multivariate-adjusted risk of diabetes diagnosis (odds ratio, 2.15; 95% CI, 2.00–2.33). During 319,758 person-years of follow-up with a mean follow-up of 12.0 years, 582 diabetes deaths were documented. Compared with people with triglyceride in the lowest quintile, people with triglyceride in the highest quintile had an 85% higher risk of diabetes mortality (HR, 1.85; 95% CI, 1.25–2.73). A 1-natural-log-unit increase in triglyceride was associated with a 40% higher multivariate-adjusted risk of diabetes mortality. The positive association between triglyceride and diabetes mortality was also presented in sub-cohorts of participants with or without diabetes. Conclusions This study demonstrated that higher fasting triglyceride was associated with a higher diabetes mortality risk.

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Section: Methodsmentioning

confidence: 99%

Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults

Wang

2021

Lipids Health Dis

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“…Confounding covariates of this study included age, gender, ethnic background (Hispanic, non-Hispanic black, non-Hispanic white, or other), obesity (underweight, normal, overweight, obese, or unknown) [13], education (<high school, high school, or >high school) [14], poverty-income ratio (<130%, 130%-349%, ≥350%, or unknown) [15], and survey periods [16]. Lifestyle confounders included physical activity (inactive, insufficiently active, or active) [7], alcohol consumption (never, <1 drink per week, 1-6 drinks per week, ≥7 drinks per week, or unknown), and cigarette smoking (smoker or non-smoker).…”

Section: Covariatesmentioning

confidence: 99%

Non-Fasting Plasma Triglycerides Are Positively Associated with Diabetes Mortality in a Representative US Adult Population

Wang,

Fang,

Zhang

et al. 2024

Targets

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This study aimed to investigate whether non-fasting plasma triglycerides were associated with diabetes mortality. It included 7312 US adult participants. Diabetes mortality data were obtained via the linkage to National Death Index (NDI) records. Hazard ratios of non-fasting plasma triglycerides for diabetes mortality were assessed using Cox proportional hazards models, adjusting for age, gender, ethnicity, obesity, poverty–income ratio, education levels, physical activity, alcohol consumption, cigarette smoking status, survey period, hypercholesterolemia, hypertension, diabetes, and family history of diabetes. Among these participants, 1180 had diabetes. A total of 420 diabetes-caused deaths were recorded during a mean follow-up of 16.8 years. A 1-natural-log-unit increase in non-fasting plasma triglycerides was associated with a 41% higher diabetes mortality risk (hazard ratio, 1.41; 95% confidence interval, 1.19–1.67). Participants with non-fasting plasma triglycerides in the highest quintile, versus those in the lowest quintile, had a 141% higher diabetes mortality risk (hazard ratio, 2.41; 95% confidence interval, 1.46–3.97). The positive association of non-fasting plasma triglycerides with diabetes mortality was independent of diabetes status at the baseline. In conclusion, this study demonstrated that non-fasting plasma triglycerides were positively associated with diabetes mortality, independent of diabetes status at baseline. Non-fasting triglycerides may be a therapeutic target for diabetes-related complications.

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“…Confounding covariates of this study included age, gender, ethnic background (Hispanic, non-Hispanic black, non-Hispanic white, or other), obesity (underweight, normal, overweight, obese, or unknown) [12], education (< high school, high school, or > high school) [13], poverty-income ratio (< 130%, 130%-349%, ≥ 350%, or unknown) [14], and survey periods [15]. Lifestyle confounders included physical activity (inactive, insufficiently active, or active) [6], alcohol consumption (never, < 1 drink per week, 1-6 drinks per week, ≥ 7 drinks per week, or unknown), and cigarette smoking (smoker or non-smoker).…”

Section: Covariatesmentioning

confidence: 99%

Non-Fasting Plasma Triglycerides Are Positively Associated with Diabetes Mortality

Wang,

Fang,

Zhang

et al. 2024

Preprint

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This study aimed to investigate whether non-fasting plasma triglycerides were associated with diabetes mortality. It included 7,312 US adult participants. Diabetes mortality data were obtained via linkage to the National Death Index (NDI) records. Hazard ratios of non-fasting plasma triglycerides for diabetes mortality were assessed using Cox proportional hazards models, adjusting for age, gender, ethnicity, obesity, poverty-income ratio, education levels, physical activity, alcohol consumption, cigarette smoking status, survey period, hypercholesterolemia, hypertension, diabetes, and family history of diabetes. Among these participants, 1,180 had diabetes. A total of 420 diabetes-caused deaths were recorded during a mean follow-up of 16.8 years. A 1-natural-log-unit increase in non-fasting plasma triglycerides was associated with a 41% higher diabetes mortality risk (hazard ratio, 1.41; 95% confidence interval, 1.19-1.67). Participants with non-fasting plasma triglycerides in the highest quintile, versus those in the lowest quintile, had a 144% higher diabetes mortality risk (hazard ratio, 2.44; 95% confidence interval, 1.49-4.02). The positive association of non-fasting plasma triglycerides with diabetes mortality was independent of diabetes status at the baseline. In conclusion, this study demonstrated that non-fasting plasma triglycerides were positively associated with diabetes mortality, independent of diabetes status at the baseline. Non-fasting triglycerides may be a therapeutic target for diabetes-related complications.

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Risk factors, incidence, and prevalence of diabetes among rural farm and non-farm residents of Saskatchewan, Canada; a population-based longitudinal cohort study

Cited by 6 publications

References 31 publications

Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults

Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults

Non-Fasting Plasma Triglycerides Are Positively Associated with Diabetes Mortality in a Representative US Adult Population

Non-Fasting Plasma Triglycerides Are Positively Associated with Diabetes Mortality

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