Risk Factors Influencing Outcomes of Atrial Fibrillation in ALLHAT

Haywood, L. Julian; Davis, Barry R.; Piller, Linda B.; Simpson, Lara M.; Ghosh, Alokananda; Einhorn, Paula T.; Ford, Charles E.; Probstfield, Jeffrey L.; Soliman, Elsayed Z.; Wright, Jackson T.

doi:10.1016/j.jnma.2017.07.003

Cited by 3 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common manifestation or complication of hypertensive heart disease is cardiac arrhythmias, and the most common among these is AFib (80). AFib is an irregular and very rapid heart rhythm associated with increased risk for blood clots in the heart, stroke, and heart failure (81)(82)(83)(84). AFib can be detected on an electrocardiography (ECG) (Figure 3).…”

Section: Mechanisms Of Conduction Arrhythmias Associated With Hyperte...mentioning

confidence: 99%

Hypertensive heart disease: risk factors, complications and mechanisms

Masenga

Kirabo

2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Hypertensive heart disease constitutes functional and structural dysfunction and pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries due to chronic uncontrolled hypertension. Hypertensive heart disease is underreported and the mechanisms underlying its correlates and complications are not well elaborated. In this review, we summarize the current understanding of hypertensive heart disease, we discuss in detail the mechanisms associated with development and complications of hypertensive heart disease especially left ventricular hypertrophy, atrial fibrillation, heart failure and coronary artery disease. We also briefly highlight the role of dietary salt, immunity and genetic predisposition in hypertensive heart disease pathogenesis.

show abstract

Section: Mechanisms Of Conduction Arrhythmias Associated With Hyperte...mentioning

confidence: 99%

Hypertensive heart disease: risk factors, complications and mechanisms

Masenga

Kirabo

2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…AF is the most frequent cardiac arrhythmia and has been associated with a two- to threefold increased risk of cardiovascular mortality and stroke and fivefold risk of congestive heart failure [ 60 , 61 ]. Experimental models suggest that hypertension may induce early and progressive changes in left atrial anatomy and function, which may promote AF through a variety of electrophysiological mechanisms [ 62 ].…”

Section: Atrial Fibrillationmentioning

confidence: 99%

The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases

Strauss

Hall

2021

Cardiovasc Drugs Ther

View full text Add to dashboard Cite

Cardiovascular disease is the leading cause of mortality worldwide, affecting a wide range of patients at different stages across the cardiovascular continuum. Hypertension is one of the earliest risk factors in this continuum and can be controlled in most patients with currently available antihypertensive agents. However, goals are often not met because treatments are not optimized in terms of tailoring therapy to individual patients based on their hypertension subclass and cardiovascular risk profile and initiating early use of adapted-dose, single-pill combinations. In this context, beta-blockers in combination with angiotensin-converting enzyme (ACE) inhibitors are of special interest as a result of their complementary actions on the sympathetic nervous system and renin–angiotensin–aldosterone system, two interlinked pathways that influence cardiovascular risk and disease outcomes. In addition to their antihypertensive actions, beta-blockers are used to manage arrhythmias and treat angina pectoris and heart failure, while ACE inhibitors provide cardioprotection in patients with acute coronary syndromes and treat congestive heart failure. A broad range of patients may therefore receive the combination in routine clinical practice. This paper examines the supporting evidence for beta-blockers and ACE inhibitors in each of the above indications and considers the rationale for combining these agents into a single pill, using data from bisoprolol and perindopril randomized controlled trials as supporting evidence. Combining these established antihypertensive agents into a single pill continues to provide effective blood pressure lowering and improved cardiovascular outcomes while allowing a greater proportion of patients to rapidly achieve treatment targets.

show abstract

“…Atrial fibrillation (AF) is the world’s most common heart rhythm disorder, associated with increased morbidity and mortality. AF is one of the leading risk factors for ischemic stroke and is also associated with developing heart failure and dementia ( 3 , 4 ). Both IHD and AF share many of the same risk factors, such as increased age, obesity, hypertension, and physical inactivity ( 5 ).…”

mentioning

confidence: 99%

Night and shift work characteristics and incident ischemic heart disease and atrial fibrillation among healthcare employees – a prospective cohort study

Kader¹,

Selander²,

Andersson³

et al. 2022

Scand J Work Environ Health

View full text Add to dashboard Cite

Objective This study aimed to examine the effects of various aspects of night and shift work on the risk of incident ischemic heart disease (IHD) and atrial fibrillation (AF) using detailed and registry-based exposure data. Methods This prospective cohort study included >30 300 healthcare employees (eg, nurses, nursing assistants) employed for at least one year in Region Stockholm 2008–2016. Information on daily working hours was obtained from a computerized administrative employee register and outcomes from national and regional registers. Using discrete-time proportional hazard models, we analyzed the outcomes as functions of working hour characteristics the preceding year, adjusted for sex, age, country of birth, education, and profession. Results We observed 223 cases of IHD and 281 cases of AF during follow-up 2009–2016. The risk of IHD was increased among employees who the preceding year had permanent night shifts compared to those with permanent day work [hazard ratio (HR) 1.61, 95% confidence interval (CI) 1.06–2.43] and among employees working night shifts >120 times per year compared to those who never worked night (HR 1.53, 95% CI 1.05–2.21). When restricted to non-night workers, the risk of IHD was increased for employees having frequent quick returns from afternoon shifts. No increased risks were observed for AF. Conclusions Night work, especially working permanent night shifts and frequent night shifts, is associated with an increased risk of incident IHD but not AF. Moreover, frequent quick returns from afternoon shifts (among non-night workers) increased IHD risk. Organizing work schedules to minimize these exposures may reduce IHD risk.

show abstract

Risk Factors Influencing Outcomes of Atrial Fibrillation in ALLHAT

Abstract: AF/AFL is a significant risk factor for stroke, HF, and mortality. Additional risk factors for these outcomes were generally similar for participants with and without baseline or incident AF/AFL.

Cited by 3 publications

References 30 publications

Hypertensive heart disease: risk factors, complications and mechanisms

Hypertensive heart disease: risk factors, complications and mechanisms

The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases

Night and shift work characteristics and incident ischemic heart disease and atrial fibrillation among healthcare employees – a prospective cohort study

Contact Info

Product

Resources

About