Risk Factors, Lifestyle Behaviors, and Vascular Brain Health

Gottesman, Rebecca F.; Seshadri, Sudha

doi:10.1161/strokeaha.121.032610

Cited by 32 publications

(25 citation statements)

References 136 publications

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“… 97 , 98 The severity of HTN to the brain depends on both stage of the disease and the age of the patient; higher risk of dementia at an elderly age as compared to young ones (65–75), and it is not effective at the age of 75–85 or > 85. 99 , 100 Furthermore, clinical data of AD patients also support this association as a directional cue. Patients in the early stage of AD show high BP values, while late-life AD patients have more severe HTN complications with substantial cognitive decline.…”

Section: Chronic Hypertension and Alzheimer’s Diseasementioning

confidence: 73%

Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population

Yao¹,

Jiang²,

Lin³

et al. 2023

CIA

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Alzheimer’s disease (AD), the most common cause of dementia and the fifth leading cause of death in the adult population has a complex pathophysiological link with hypertension (HTN). A growing volume of published literature on a parallel elevation of blood pressure (BP), amyloid plaques, and neurofibrillary tangles formation in post-middle of human brain cells has developed new, widely accepting foundations on this association. In particular, HTN in elderly life mediates cerebral blood flow dysfunction, neuronal dysfunction, and significant decline in cognitive impairment, primarily in the late-life populace, governing the onset of AD. Thus, HTN is an established risk factor for AD. Considering the impact of AD, 1.89 million deaths annually, and the failure of palliative therapies to cure AD, the scientific research community is looking to adopt integrated approaches to target early modified risk factors like HTN to reduce AD burden. The current review highlights the significance and impact of HTN-based prevention in lowering the AD burden in the elderly by providing a comprehensive overview of the physiological relationship between AD and HTN with an in-detail explanation of the role and applications of pathological biomarkers in this clinical association. The review will gain worth in presenting new insights and providing inclusive discussion on the correlation between HTN and cognitive impairment. It will increase across a wider scientific audience to expand understanding of this pathophysiological association.

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Section: Chronic Hypertension and Alzheimer’s Diseasementioning

confidence: 73%

Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population

Yao¹,

Jiang²,

Lin³

et al. 2023

CIA

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“…Vascular disease is the only known major treatable contributor to NCD, and it is especially present in stroke patients (Hachinkski, 2021). Vascular health, brain health, and stroke are closely linked, with cardiovascular risk factors for stroke also being important factors for brain health (Gottesman & Seshadri, 2022). For example, hypertension can have effects on brain volume up to 24 years into the future (Power et al, 2016), and is a major risk factor for stroke (Feigin et al, 2016).…”

Section: Brain Healthmentioning

confidence: 99%

Longitudinal brain age prediction and cognitive function after stroke

Aamodt

Alnæs²,

Lange³

et al. 2023

Neurobiology of Aging

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“…The papers were then read in full and key themes identified; decisions about what constituted a key theme were guided by the review question and through identifying the occurrence of the primary and secondary search terms developed for this review in the papers selected. The prevention of adverse brain change requires the consideration of multiple lifestyle and risk factors 49 and the threats to brain health arise because of impairment to cardiovascular function.…”

Section: Journal Of Health Promotion and Education; The Journal Of Pr...mentioning

confidence: 99%

Exploring what progress is being made in the development of health promotion material for vascular dementia: A systematic review of the evidence

Price

2023

Aging Medicine

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A systematic review conducted by Price and Keady (Journal of Nursing and Healthcare of Chronic Illness, 2, 88 and 2010) demonstrated that there was a dearth of health‐promoting literature available for people diagnosed with vascular dementia. The correlation between health behavior and the onset of cardiovascular change that can lead to vascular dementia had demonstrated a need for health education and health‐promoting information to be made accessible to vulnerable populations to ameliorate the risk of cognitive decline because of cardiovascular disease. Dementia is a progressive and life‐limiting condition and with limited treatment options and a lack of progress in identifying a way to delay onset or even cure the condition. Focus must be targeted towards risk reduction strategies that serve to reduce onset and decline and limit the global burden on not only the individual with the condition and their carers but also to the health and social care economy. To identify the progress that has been made in developing health‐promoting literature and patient education guidance since 2010 a systematic literature review was undertaken. Using thematic analysis, CINAHL, MEDLINE, and psych INFO databases were accessed and following PRISMA guidelines an inclusion and exclusion criteria was developed in order to locate peer‐reviewed articles. Titles and abstracts were reviewed to identify a match with key terms, and from 133 screened abstracts eight studies met the inclusion requirements. From the eight studies, thematic analysis was implemented to identify shared understanding of experiences relating to health promotion in vascular dementia. The methodology for the study was replicated from the authors’ previous systematic review in 2010. Five key themes were identified in the literature (Healthy heart healthy brain; Risk factors; Risk reduction/modification; Interventions; Absence of targeted health promotion). From what little evidence was available to review the thematic analysis has demonstrated developments in knowledge into the link between the onset of cognitive impairment and vascular dementia because of compromised cardiovascular health. Modifying health behavior has become essential in ameliorating the risk of vascular cognitive decline. With these developments the synthesis of the literature demonstrates that even with these insights there continues to be a lack of targeted material that individuals can access to understand the link between cardiovascular health and cognitive decline. It is recognized that maximizing cardiovascular health has the potential to lessen the risk of vascular cognitive impairment and vascular dementia developing and progressing yet targeted health promoting material remains lacking. With the developments in understanding the causal links between poor cardiovascular health, vascular cognitive impairment, and vascular dementia progress now needs to be made in developing targeted health promotion material for individuals to access to share this knowledge to reduce the potential ...

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Risk Factors, Lifestyle Behaviors, and Vascular Brain Health

Cited by 32 publications

References 136 publications

Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population

Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population

Longitudinal brain age prediction and cognitive function after stroke

Exploring what progress is being made in the development of health promotion material for vascular dementia: A systematic review of the evidence

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